Results 61 to 70 of about 689,040 (308)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Effects of transmitters and amyloid-beta peptide on calcium signals in rat cortical astrocytes: Fura-2AM measurements and stochastic model simulations. [PDF]

PLoS ONE, 2011
BACKGROUND: To better understand the complex molecular level interactions seen in the pathogenesis of Alzheimer's disease, the results of the wet-lab and clinical studies can be complemented by mathematical models. Astrocytes are known to become reactive
Eeva Toivari, Tiina Manninen, Amit K Nahata, Tuula O Jalonen, Marja-Leena Linne   +4 more
doaj   +1 more source

Hysteresis and bi-stability by an interplay of calcium oscillations and action potential firing

, 2006
Many cell types exhibit oscillatory activity, such as repetitive action potential firing due to the Hodgkin-Huxley dynamics of ion channels in the cell membrane or reveal intracellular inositol triphosphate (IP$_3$) mediated calcium oscillations (CaOs ...
A. P. R. Theuvenet, C. C. A. M. Gielen, D. L. Ypey, J. Guckenheimer, J. M. A. M. Kusters, J. M. Cortes, J. D. Murray, O. Aslanidi, T. R. Chay, W. P. M. van Meerwijk   +9 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Calcium Channel Opening Rather than the Release of ATP Causes the Apoptosis of Osteoblasts Induced by Overloaded Mechanical Stimulation

Cellular Physiology and Biochemistry, 2017
Background: Stress fracture is one of the most common overuse injuries in athletes. Overloaded mechanical stimulation is an important factor affecting stress fractures, but the mechanism is unclear.
Lu Liu, Hui Li, Ying Cui, Ruixin Li, Fan Meng, Zi Ye, Xizheng Zhang   +6 more
doaj   +1 more source

Ketamine effect on intracellular and mitochondrial calcium mobilization [PDF]

, 2016
The suppressive effects of ketamine on intracellular calcium has been reported in a variety of cells although the mechanisms involved are not well understood.
Bustamante, Jaunita, Czerniczyniec, Analia, Lores Arnaiz, Silvia   +2 more
core  

Phagosome-lysosome fusion is a calcium-independent event in macrophages. [PDF]

, 1996
Phagosome-lysosome membrane fusion is a highly regulated event that is essential for intracellular killing of microorganisms. Functionally, it represents a form of polarized regulated secretion, which is classically dependent on increases in ...
Ernst, JD, Gustavsson, M, Majeed, M, Sanan, DA, Stendahl, O, Zimmerli, S   +5 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Regulation of PKC mediated signaling by calcium during visceral leishmaniasis. [PDF]

PLoS ONE, 2014
Calcium is an ubiquitous cellular signaling molecule that controls a variety of cellular processes and is strictly maintained in the cellular compartments by the coordination of various Ca2+ pumps and channels.
Nivedita Roy, Supriya Chakraborty, Bidisha Paul Chowdhury, Sayantan Banerjee, Kuntal Halder, Saikat Majumder, Subrata Majumdar, Parimal C Sen   +7 more
doaj   +1 more source

Wave nucleation rate in excitable systems in the low noise limit

, 2003
Motivated by recent experiments on intracellular calcium dynamics, we study the general issue of fluctuation-induced nucleation of waves in excitable media.
A. Neiman, A. Pumir, A. Winfree, B. Lindner, H. Braun, H.A. Kramers, Herbert Levine, Hervé Henry, I. Llano, I. Sendina-Nadal, J. Freire, J. Marchant, J. Nocedal, J. Shuai, M. Berridge, M. Falcke, M. Falcke, M. Marder, M. Marder, P. Jung, P. Pelcé, R. Graham, R. Maier, S. Alonso, U. Bisang   +24 more
core   +1 more source