Results 71 to 80 of about 689,040 (308)

A multiscale hybrid model for pro-angiogenic calcium signals in a vascular endothelial cell [PDF]

, 2012
Cytosolic calcium machinery is one of the principal signaling mechanisms by which endothelial cells (ECs) respond to external stimuli during several biological processes, including vascular progression in both physiological and pathological conditions ...
A. Balter, A. F. M. Marée, A. F. M. Marée, A. Fiorio Pla, A. Fiorio Pla, A. Fiorio Pla, A. Hunding, A. L. Bauer, A. M. Patton, A. Mottola, A. Tosin, A. W. Mahoney, B. Alberts, B. Nilius, C. C. Fink, C. D. Nobes, C. J. Drake, C. R. Kahl, C. Tomatis, D. Ambrosi, D. E. Clapham, D. Hong, D. Lovisolo, D. Wang, E. C. Kohn, E. C. Kohn, E. D. Perryn, E. L. Watson, F. Bussolino, F. Graner, F. Mac Gabhann, F. Moccia, G. Barbiero, G. Serini, H. Gerhardt, H. Kimura, H.-Y. Kwan, I. Fleming, J. A. Glazier, J. A. Glazier, J. Bennett, J. Howard, J. Klingauf, J. M. Haugh, J. R. Lancaster Jr., J. S. Pollock, J. Sneyd, J. Sneyd, K. S. Bauer, L. A. Blatter, L. Munaron, L. Munaron, L. Munaron, L. Munaron, L. Munaron, L. Munaron, L. Munaron, L. Munaron, L. Santella, L. V. Hryshko, M. A. Albrecht, M. D. Bootman, M. J. Berridge, M. J. Berridge, M. J. Berridge, M. J. Berridge, M. Kraus, M. S. Jafri, M. S. Steinberg, M. S. Steinberg, M. Scianna, M. Scianna, Marco Scianna, N. J. Poplawski, N. J. Savill, N. Metropolis, N. Wang, P. A. Valant, P. Bayley, P. Carmeliet, P. Carmeliet, P. Pacher, R. E. Dolmetsch, R. M. H. Merks, R. M. H. Merks, R. M. H. Merks, R. M. H. Merks, R. Meili, R. Rizzuto, S. Etienne-Manneville, S. Feske, S. Funamoto, S. Huang, S. Lin, S. M. Rafelski, S. Mittara, S. P. Khanapure, S. Wang, T. D. Pollard, T. Walther, W. Coatesworth, Y. Goto, Y. Takai   +102 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

R-type calcium channels are crucial for semaphorin 3A-induced DRG axon growth cone collapse. [PDF]

PLoS ONE, 2014
Semaphorin 3A (Sema3A) is a secreted protein involved in axon path-finding during nervous system development. Calcium signaling plays an important role during axonal growth in response to different guidance cues; however it remains unclear whether this ...
Rimantas Treinys, Andrius Kaselis, Emmanuel Jover, Dominique Bagnard, Saulius Šatkauskas   +4 more
doaj   +1 more source

Intracellular calcium channels in protozoa [PDF]

European Journal of Pharmacology, 2014
Ca(2+)-signaling pathways and intracellular Ca(2+) channels are present in protozoa. Ancient origin of inositol 1,4,5-trisphosphate receptors (IP3Rs) and other intracellular channels predates the divergence of animals and fungi as evidenced by their presence in the choanoflagellate Monosiga brevicollis, the closest known relative to metazoans.
Docampo, Roberto, Moreno, Silvia N J, Plattner, Helmut   +2 more
openaire   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Rapid progesterone actions on thymulin-secreting epithelial cells cultured from rat thymus [PDF]

, 1999
Many soluble factors of neural, endocrine, paracrine and autocrine origin are present in the thymus and modulate its function. Long-term effects of sex steroids have! been documented for thymocytes and cells of the thymic microenvironment. In this report
Brucker, Cosima, Downing, James E. G., Head, Gail M., Kendall, Marion D., Mentlein, Rolf   +4 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tissue-tissue interaction-triggered calcium elevation is required for cell polarization during Xenopus gastrulation. [PDF]

PLoS ONE, 2010
The establishment of cell polarity is crucial for embryonic cells to acquire their proper morphologies and functions, because cell alignment and intracellular events are coordinated in tissues during embryogenesis according to the cell polarity. Although
Asako Shindo, Yusuke Hara, Takamasa S Yamamoto, Masamichi Ohkura, Junichi Nakai, Naoto Ueno   +5 more
doaj   +1 more source

The Inositol- 1,4,5=Trisphosphate System Is Involved in Rapid Effects of Aldosterone in Human Mononuclear Leukocytes [PDF]

, 1993
There is increasing evidence for rapid steroid action on electrolyte transport in human mononuclear leukocytes (HML). In HML, aldosterone stimulates the Na+/H+ antiporter within a few minutes. Because a variety of hormones and growth factors activate the
Aktas, Janet, Christ, Michael, Eisen, Christoph, Theisen, Karl, Wehling, Martin   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source