Results 221 to 230 of about 3,145,194 (361)

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

open access: yesAdvanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo   +8 more
wiley   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

open access: yesAdvanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang   +5 more
wiley   +1 more source

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

open access: yesAdvanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso   +5 more
wiley   +1 more source

Antimicrobial Titanium–Copper Alloys: The Role of Microstructure in Arc‐Melted Compositions

open access: yesAdvanced Engineering Materials, EarlyView.
Copper‐containing titanium alloys show promise in combating orthopedic implant infections. This study explores the influence of heat treatment on Ti‐11.5Cu and Ti‐33Cu alloys, revealing that larger Ti2Cu precipitates (≈5 μm) enhance antimicrobial efficacy through increased surface contact. Results suggest contact sterilization is the primary mechanism,
Daisy Rabbitt   +5 more
wiley   +1 more source

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