Phagocytosis of Legionella pneumophila is mediated by human monocyte complement receptors. [PDF]
We have examined receptors mediating phagocytosis of the intracellular bacterial pathogen, Legionella pneumophila. Three mAbs against the type 3 complement receptor (CR3), which recognizes C3bi, inhibit adherence of L.
Horwitz, MA, Payne, NR
core
Cn-AMP2 from green coconut water is an anionic anticancer peptide [PDF]
Globally, death due to cancers is likely to rise to over 20 million by 2030,which has created an urgent need for novel approaches to anticancer therapies such as the development of host defence peptides.
Al-Benna+56 more
core +1 more source
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink+6 more
wiley +1 more source
A crude extract (B10) of Aspergillus niger spores showed effective antibacterial activity against Agrobacterium tumefaciens T-37. The inhibition rate was 98.22%, and the half maximal inhibitory concentration was 0.035 ± 0.018 mg/mL.
Kun Guo+7 more
doaj +1 more source
Measurement of the cell membrane capacitance and conductance of colonic crypt cells of the rat using the patch clamp technique [PDF]
Using the patch clamp technique the membrane capacitance and membrane conductance of colonic crypt cells of the rat was measured. The influence of the intracellular agonists Ca++, cAMP and of osmotic changes on the membrane capacitance and conductance was studied.
arxiv
Membrane Stimulation and Intracellular Killing by Monocytes
The present paper reviews our recent studies concerning the intracellular killing of bacteria by human monocytes and compares the results with those found for circulating granulocytes. The findings show that optimal intracellular killing of catalase-positive and catalase-negative bacteria is only reached during interaction of the Fc part of IgG and ...
Peter C. J. Leijh, R. Van Furth
openaire +3 more sources
Organic Cation Transporter 3 (OCT3) Is Localized to Intracellular and Surface Membranes in Select Glial and Neuronal Cells Within the Basolateral Amygdaloid Complex of Both Rats and Mice [PDF]
Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin. OCT3 is expressed widely throughout the
Chan, June+3 more
core +2 more sources
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi+3 more
wiley +1 more source
Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease
Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh+5 more
wiley +1 more source
The SPCA1 Ca2+ Pump and Intracellular Membrane Trafficking [PDF]
The Golgi apparatus (GA) is a dynamic store of Ca(2+) that can be released into the cell cytosol. It can thus participate in the regulation of the Ca(2+) concentration in the cytosol ([Ca(2+) ](cyt) ), which might be critical for intra-Golgi transport.
Massimo, Micaroni+4 more
openaire +5 more sources