Results 201 to 206 of about 181,797 (206)

Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI

Nature Medicine, 2003
In the past decade, it has become possible to use the nuclear (proton, 1H) signal of the hydrogen atoms in water for noninvasive assessment of functional and physiological parameters with magnetic resonance imaging (MRI). Here we show that it is possible to produce pH-sensitive MRI contrast by exploiting the exchange between the hydrogen atoms of water
Jinyuan, Zhou, Jean-Francois, Payen, David A, Wilson, Richard J, Traystman, Peter C M, van Zijl   +4 more
openaire   +2 more sources

The Peptides Mimicking the Third Intracellular Loop of 5-Hydroxytryptamine Receptors of the Types 1B and 6 Selectively Activate G Proteins and Receptor-Specifically Inhibit Serotonin Signaling via the Adenylyl Cyclase System

International Journal of Peptide Research and Therapeutics, 2010
The third intracellular loop (ICL3) of G protein-coupled receptors has, as a rule, a key role in their interaction with heterotrimeric G proteins. We synthesized peptides corresponding to the C-terminal region of the ICL3 (C-ICL3) of 5-hydroxytryptamine receptors of the type 1B (5-HT1BR) and 6 (5-HT6R) and studied their influence on the functional ...
Alexander O. Shpakov, Elena A. Shpakova, Irina I. Tarasenko, Kira V. Derkach, Gennady P. Vlasov   +4 more
openaire   +1 more source