Results 81 to 90 of about 500,548 (294)

Longitudinal, Multimodal Tracking Reveals Lasting Neurovascular Impact of Individual Microinfarcts

Advanced Science, EarlyView.
Jin et al. investigate the neurovascular impact of microinfarcts, revealing transient neural suppression with minimal cell death and recovery linked to vascular remodeling. Fast‐spiking interneurons exhibit reduced excitability, whereas regular‐spiking neurons showed increased bursting activity. Disruptions in low‐gamma phase locking suggest persistent
Yifu Jin, Fei He, Haad Rathore, Yingchu Sun, Jia‐ao Zhang, Xinyu Li, Rongkang Yin, Hanlin Zhu, Chong Xie, Lan Luan   +9 more
wiley   +1 more source

Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage

Frontiers in Pharmacology, 2019
Intracerebral hemorrhage (ICH) is a subtype of hemorrhagic stroke with high mortality and morbidity. The resulting hematoma within brain parenchyma induces a series of adverse events causing primary and secondary brain injury.
Zhiwei Shao, Sheng Tu, Anwen Shao
semanticscholar   +1 more source

Correlation Between Blood Glucose Level and Cerebral Small Vessel Disease Markers in Neurologically Asymptomatic, Nondiabetic Individuals

AGING MEDICINE, EarlyView.
The prevalence of neurologically asymptomatic CSVD is common in the nondiabetic population. Glycated hemoglobin A1c correlated with periventricular white matter hyperintensities. Fasting blood glucose was associated with deep cerebral microbleeds. Better control of blood glucose may have a beneficial effect on reducing the risk of CSVD.
Xinxin Ma, Fang Liu, Lei Qiu, Juan Chen, Wei Du, Jing He, Aizhen Sheng, Yinhong Liu   +7 more
wiley   +1 more source

Fusion of medical imaging and electronic health records with attention and multi-head machanisms [PDF]

arXiv, 2021
Doctors often make diagonostic decisions based on patient's image scans, such as magnetic resonance imaging (MRI), and patient's electronic health records (EHR) such as age, gender, blood pressure and so on. Despite a lot of automatic methods have been proposed for either image or text analysis in computer vision or natural language research areas ...
arxiv  

Perihematomal Edema After Spontaneous Intracerebral Hemorrhage.

Stroke, 2019
Mechanical disruption of adjacent neurons and glia after intracerebral hemorrhage (ICH) can result in both immediate and delayed neurological injury, with the eventual consequences of long-term functional impairment and mortality. In patients who survive
N. Ironside, Ching-Jen Chen, D. Ding, S. Mayer, E. Connolly   +4 more
semanticscholar   +1 more source

Transplanting neural stem cells overexpressing miRNA‐21 can promote neural recovery after cerebral hemorrhage through the SOX2/LIN28‐let‐7 signaling pathway

Animal Models and Experimental Medicine, EarlyView.
Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai, Yongxia Li, Jiarui Du, Gang Shen, Meimei Fan, Zuopeng Su, Fulin Xu, Fang Yuan   +7 more
wiley   +1 more source

The constitutional gain‐of‐function variant p.Glu1099Lys in NSD2 is associated with a novel syndrome

Clinical Genetics, Volume 103, Issue 2, Page 226-230, February 2023., 2023
The gain‐of‐function variant p.Glu1099Lys in NSD2 was described in hematologic malignancies while germline loss‐of‐function was associated with Wolf–Hirschhorn syndrome and Rauch–Steindl syndrome. Now we associate this variant identified in the germinal of two individuals with a novel syndrome characterized by intellectual disability, coarse/ square ...
Bernt Popp, Melanie Brugger, Sibylle Poschmann, Tobias Bartolomaeus, Maximilian Radtke, Julia Hentschel, Nataliya Di Donato, Andreas Rump, Janina Gburek‐Augustat, Elisabeth Graf, Matias Wagner, Ina Sorge, Johannes R Lemke, Thomas Meitinger, Rami Abou Jamra, Vincent Strehlow, Theresa Brunet   +16 more
wiley   +1 more source

Recent advances in spontaneous intracerebral hemorrhage

F1000Research, 2019
Intracerebral hemorrhage (ICH) is a stroke subtype associated with significant morbidity and mortality. The purpose of this review is to provide an update on important research on ICH over the past three years.
Ravi Garg, J. Biller
semanticscholar   +1 more source

Intravenous Thrombolysis in Patients Taking Direct Oral Anticoagulation Treatment Before Stroke Onset: Results from the Safe Implementations of Treatments in Stroke International Stroke Registry

Annals of Neurology, EarlyView.
Objectives Intravenous thrombolysis (IVT) is contraindicated for acute ischemic stroke (AIS) patients taking direct oral anticoagulants (DOACs) within 48 hours before index stroke. Limited data exist on off‐label use of IVT for these patients. We compared the safety and outcomes of IVT in AIS patients with DOAC treatment and patients with no OAC before
Marius Matusevicius, Malin Säflund, Maurizio Balestrino, Manuel Cappellari, Delfina Ferrandi, Abdoreza Ghoreishi, André Peeters, Viiu‐Marika Rand, Manuela De Michele, Aleksandras Vilionskis, Andrea Zini, Niaz Ahmed   +11 more
wiley   +1 more source

Donor hypernatremia is associated with increased mortality after heart transplantation: A retrospective study

Clinical Transplantation, Volume 36, Issue 12, December 2022., 2022
Abstract Background and aims Donor hypernatremia has been associated with primary graft dysfunction in heart transplantation (HTx) and is correlated with impaired outcome following liver and renal transplantation. However, controversial data exist regarding the impact of sodium dysregulation on survival.
Daniel Oehler, Moritz Benjamin Immohr, Charlotte Böttger, Raphael Romano Bruno, Dennis Sigetti, Jafer Haschemi, Hug Aubin, Patrick Horn, Igor Tudorache, Ralf Westenfeld, Payam Akhyari, Malte Kelm, Artur Lichtenberg, Udo Boeken   +13 more
wiley   +1 more source