Results 91 to 100 of about 5,243,950 (288)

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Effects of moderate sedation induced by propofol or midazolam on intracranial pressure

ABCS Health Sciences
Introduction: Propofol and midazolam are the main options for moderate sedation in clinical practice. In addition, these drugs are used to reduce intracranial pressure in cases of intracranial hypertension, and their use in these situations is guided by
Bianca Drewnowski, José Carlos Rebuglio Vellosa, Rafael Nastas Acras, Fábio André dos Santos   +3 more
doaj   +1 more source

Brain herniation in a patient with apparently normal intracranial pressure: a case report

Journal of Medical Case Reports, 2010
Introduction Intracranial pressure monitoring is commonly implemented in patients with neurologic injury and at high risk of developing intracranial hypertension, to detect changes in intracranial pressure in a timely manner.
Dahlqvist Mats B, Andres Robert H, Raabe Andreas, Jakob Stephan M, Takala Jukka, Dünser Martin W   +5 more
doaj   +1 more source

Tumor‐Intrinsic HEXB Drives Endothelial‐To‐Mesenchymal Transition and Confers Resistance to Anti‐Angiogenic Therapy in Glioblastoma

Advanced Science, EarlyView.
This study elucidates how glioblastoma tumors develop resistance to anti‐VEGF therapy through endothelial‐to‐mesenchymal transition (Endo‐MT). The researchers identify a novel signaling pathway where tumor‐derived HEXB stabilizes HSP60 to drive this vascular reprogramming.
Tianqi Liu, Xin Chen, Tao Sun, Jianqi Wu, Haixu Yan, Xing Liu, Hongda Lin, Xiangyu Wang, Ziao Xiao, Yang Xu, Qiang Fu, Peng Cheng, Wen Cheng, Anhua Wu   +13 more
wiley   +1 more source

Case Report: Stepwise quantitative assessment of intraoperative intracranial pressure after perforation, craniotomy, dural incision, and hematoma removal in acute subdural hematoma

Frontiers in Surgery
IntroductionSevere traumatic brain injury often requires emergency surgical intervention such as craniotomy or decompressive craniectomy. The timely reduction of intracranial pressure (ICP) is critical for improving neurological outcomes.
Sota Wakahara, Ryota Tamura, Takahiro Iinuma, Konosuke Ishikawa, Kosuke Karatsu, Ryo Yamamoto, Yukio Sato, Junichi Sasaki, Masahiro Toda   +8 more
doaj   +1 more source

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Effect of intermittent pneumatic compression on intracranial pressure in postoperative patients with severe traumatic brain injury

Journal of International Medical Research
Objective To evaluate whether intermittent pneumatic compression therapy influences intracranial pressure in postoperative patients with severe traumatic brain injury.
Bing Xue, Zhen Yong, Jiannan Zhang
doaj   +1 more source

Intracranial Pressure and its Monitoring in Childhood: A Review

, 1987
Failure to measure intracranial pressure (ICP) in the childhood encephalopathies has been likened to treating heart failure without measuring the blood pressure.
R W Newton
core   +1 more source

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source

New perspectives in the 14th International Conference on Intracranial Pressure and Brain Monitoring

, 2011
The first conference focusing on the measurement of intracranial pressure took place in 1972 in Hannover, Germany. Since then, every 2–3 years, scientists and clinicians from all over the world come together and present their latest findings and ...
Christian Zweifel, Adel Helmy
core   +1 more source