Results 81 to 90 of about 5,243,950 (288)

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

[Intracranial pressure monitoring].

Revista da Escola de Enfermagem da U S P, 1981
Este trabalho apresenta alguns aspectos básicos da monitorização intracraniana, necessários para o desempenho eficaz da enfermeira que assiste pacientes submetidos a esse procedimento.
openaire   +2 more sources

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

Intracranial pressure monitoring in the torture chamber

Revista Brasileira de Terapia Intensiva, 2015
a large number of editorials, reviews, and new studies have addressed the issue of whether the monitoring of intracranial pressure (ICP) is relevant in the management of severe head injury and whether the costs are justified to achieve a better outcome.
openaire   +2 more sources

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

无创颅内压监测的研究进展 Research Progress of Noninvasive Intracranial Pressure Monitoring

Zhongguo cuzhong zazhi
颅内压是指颅腔内容物对颅腔壁的压力，其变化能反映颅内的生理、病理变化情况。成人平卧位的颅内压持续维持在15 mmHg（1 mmHg=0.133 kPa）以上，即为颅内高压。目前，颅内压的监测方法以有创的脑室外引流和实质内探针为“金标准”，然而该方法存在感染风险高、易导致脑损伤和出血等缺陷，且成本高昂。鉴于此，探寻一种安全、精确的无创颅内压监测手段显得尤为关键。本文综述无创颅内压监测的最新研究进展，比较分析了多种技术方法的优势与缺陷，脑成像技术、TCD、脑电图 ...
陈云娜，霍发荣，赵龙，谭亚芳，张晓燕(CHEN Yunna, HUO Farong, ZHAO Long, TAN Yafang, ZHANG Xiaoyan)
doaj   +1 more source

Targeted Mechanogenetics to Modulate Specific Deep Neural Circuits

Advanced Science, EarlyView.
This study introduces mechanogenetics, a nanobubble‐enhanced sonogenetic strategy for selective modulation of feeding‐related neural circuits in the mouse lateral hypothalamus. Mechanogenetic stimulation modulates feeding behavior through glutamatergic projections from the lateral hypothalamus to the ventral tegmental area, highlighting its potential ...
Xuandi Hou, Jianing Jing, Zhuohan Shi, Lei Sun   +3 more
wiley   +1 more source

Ambulatory intracranial pressure in humans: ICP increases during movement between body positions

Brain and Spine
Introduction: Positional changes in intracranial pressure (ICP) have been described in humans when measured over minutes or hours in a static posture, with ICP higher when lying supine than when sitting or standing upright.
Eleanor M. Moncur, Linda D'Antona, Amy L. Peters, Graziella Favarato, Simon Thompson, Celine Vicedo, Lewis Thorne, Laurence D. Watkins, Brian L. Day, Ahmed K. Toma, Matthew J. Bancroft   +10 more
doaj   +1 more source