Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model. [PDF]
Fakih HH +21 more
europepmc +1 more source
Geometry Analysis of Two Photon Polymerized Microneedles—An Experimental and Simulated Approach
This research investigates the mechanical stability of hollow, two‐photon‐polymerized microneedles for drug delivery. In an experimental setup, a steel stamp gradually compresses 1000 μm‐tall microneedles while recording their force–deformation response.
Cordelia F. Wittemann +4 more
wiley +1 more source
Additional Evidence Fails to Associate Variation in KCNE4 With Equine Anhidrosis
ABSTRACT A prior genome‐wide association (GWA; N = 200) including Thoroughbreds and stock horses implicated chromosome 6 (NC_009149.3) in owner‐reported equine anhidrosis. A missense variant in KCNE4 (NC_009149.3:g.11813731A>G) was proposed as a risk allele, although its association with anhidrosis was not reported.
Jessica L. Petersen, Carrie J. Finno
wiley +1 more source
Xanthelasma-Like Reaction Following Poly-L-Lactic Acid Intradermal Injection Managed With Fractional Non-Ablative Lasers and Stem Cell-Derived Conditioned Media: A Case Report. [PDF]
Wibisono O, Fang M, Yi KH, Junawanto I.
europepmc +1 more source
HIF2A as a prognostic and clinical therapeutic target in ovarian clear cell carcinoma
What's new? Ovarian clear cell carcinoma is highly associated with hypoxia. Hypoxia‐inducible factor 2A (HIF2A) is a key regulator of hypoxic responses, but its role in ovarian clear cell carcinoma remains unclear. This study demonstrated the unfavorable prognostic significance of HIF2A expression in ovarian clear cell carcinoma.
Mengxin Jiang +15 more
wiley +1 more source
Exploring the Effectiveness, Tolerability, and Safety of the Adjunctive Use of Microneedling With Tranexamic Acid in the Treatment of Melasma. [PDF]
Dhaliwal S, Dhanoa N, Rashid Z.
europepmc +1 more source
Pharmacy‐Based Immunization Delivery: A Comprehensive History and Current Challenges
ABSTRACT Pharmacists and their teams have a long history of involvement with vaccines. This paper describes the contributions of pharmacy‐based immunization delivery in the United States from the 1800's to date. Early activities centered around storage and distribution of antitoxins and vaccines. From the 1950s through the early 1990s, pharmacists were
Jean‐Venable R. Goode +4 more
wiley +1 more source
Supersonic Cryogenic Jet Delivery of Polynucleotides Compared With Manual Intradermal Injection. [PDF]
Kim M +5 more
europepmc +1 more source
Specific selection of antigen-reactive lymphocytes into antigenically stimulated lymph nodes in sheep [PDF]
Hopkins, John +2 more
core +1 more source
Alternate Light Source (ALS) Detection Does Not Confirm Occult Bruises
Visible light spectrum. ABSTRACT Almost all victims of assault and strangulation who seek medical care receive their initial medical care in the emergency department (ED), and many patients are referred to forensic nurses during or immediately after the ED evaluation.
William Hauda II +5 more
wiley +1 more source

