Expression Kinetics and Innate Immune Response after Electroporation and LNP-Mediated Delivery of a Self-Amplifying mRNA in the Skin [PDF]
Molecular Therapy: Nucleic Acids, 2019 In this work, we studied the expression kinetics and innate immune response of a self-amplifying mRNA (sa-RNA) after electroporation and lipid-nanoparticle (LNP)-mediated delivery in the skin of mice. Intradermal electroporation of the sa-RNA resulted in
Hanne Huysmans +8 more
doaj +3 more sources
Investigating the Mechanisms of Intradermal Injection for Easier “Skin Booster” Treatment: A Fluid Mechanics Approach to Determine Optimal Delivery Method [PDF]
Plastic and Reconstructive Surgery, Global OpenBackground:. The use of “skin boosters” for rejuvenating aged skin is widely used. However, the accurate injection of the skin booster into the dermal layer remains a challenge due to the density of the dermis.
Seung Min Oh, MD +3 more
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A Promising Needle-Free Pyro-Drive Jet Injector for Augmentation of Immunity by Intradermal Injection as a Physical Adjuvant [PDF]
International Journal of Molecular Sciences, 2023 Yasuhiro Katahira, Takayuki Yoshimoto
exaly +2 more sources
The Effects of Botulinum Toxin (BTXA) Dermal Injections on Facial Wrinkle Lines. [PDF]
Archives of Aesthetic Plastic Surgery, 2013 Facial rejuvenation using Botulinum toxin A is one of the most popular aesthetic procedures. Many cosmetic applications of Botulinum toxin A are under evaluation.
Sung Chul Park +3 more
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BMC Anesthesiology, 2023 Background Pain intensity may be varied during the needle advancing through different skin layers, injection into the intradermal layer may exclude mixed pain from deeper planes. This study aimed to investigate whether compressing a three-dimensional (3D)
Jiong Yu +3 more
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Dermatology Reports, 2023 Botulinum toxin type A (BTA) is a neurotoxin used for both cosmetic and non-cosmetic purposes. BTA is commonly administered as an intramuscular injection to treat wrinkles.
Mohammed Almashali +2 more
doaj +1 more source
Veterinary Sciences, 2023 Pruritic models in healthy dogs utilizing intravenous administration of interleukin 31 (IL-31) bypass the “natural” itch sensation in AD, which is initiated by pruriceptive primary afferent neurons in the skin.
Jason Pearson +5 more
doaj +1 more source
Suppression of FGF5 and FGF18 Expression by Cholesterol-Modified siRNAs Promotes Hair Growth in Mice
Frontiers in Pharmacology, 2021 FGF5 and FGF18 are key factors in the regulation of the hair follicle cycle. FGF5 is overexpressed during the late anagen phase and serves as a crucial regulatory factor that promotes the anagen-to-catagen transition in the hair follicle cycle.
Jungang Zhao +9 more
doaj +1 more source
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2022 Background Diabetes mellitus is commonly complicated by diabetic peripheral neuropathy. Poor adherence to medication is common in diabetic peripheral neuropathy mainly due to common side effects and poor tolerance to medication.
Dina Elsayed Gaber, Hany M. El Deeb
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A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration [PDF]
, 2014 Strategies to optimize responses to seasonal influenza vaccination in older adults include the use of adjuvants, higher antigen doses, and intradermal delivery.
Castellino, Flora +9 more
core +1 more source