Results 81 to 90 of about 6,307 (145)

Unveiling the intriguing relationship: oncogenic KRAS, morphological shifts, and mutational complexity in pancreatic mucinous cystic neoplasms

The Journal of Pathology, Volume 265, Issue 4, Page 401-407, April 2025.
Abstract Pancreatic ductal adenocarcinoma (PDAC) often arises from preexisting cystic lesions such as intraductal papillary mucinous neoplasms (IPMN) and mucinous cystic neoplasms (MCN). This study investigated the molecular heterogeneity and mutational landscape of MCN in relation to PDAC, highlighting the significance of KRAS mutations in tumor ...
Lucas‐Alexander Schulte, Annika Beck, Ralf Marienfeld, Ninel Azoitei, Thomas FE Barth, Alica Beutel, Vladimir Benes, Markus W Büchler, Nadine Therese Gaisa, Katja Kilani, Nathalia Giese, Christoph W Michalski, Peter Möller, Lukas Perkhofer, Tobias Rausch, Stefan Repky, Elodie Roger, Jeanette Scheible, Thomas Seufferlein, Peter Schirmacher, Andreas Wolfgang Berger, Thilo Hackert, Alexander Kleger   +22 more
wiley   +1 more source

Microwave Thermal Ablation in an Unusual Case of Malignant and Locally Advanced Rare Tumor of Pancreas in ASA IV Old Male Patient and Literature Review

Case Reports in Gastrointestinal Medicine, 2018
Pancreatic intraductal papillary-mucinous neoplasm is a rare primary neoplasm of unknown pathogenesis. This kind of tumor represents 0.2–2.7% of all pancreatic cancers and they may proceed to malignant lesions.
Francesco D’Amico, Michele Finotti, Chiara Di Renzo, Alessio Pasquale, Alessandra Bertacco, Giorgio Caturegli, Gabriel E. Gondolesi, Umberto Cillo   +7 more
doaj   +1 more source

Mutational Analysis of Bile Cell‐Free DNA in Primary Sclerosing Cholangitis: A Pilot Study

Liver International, Volume 45, Issue 4, April 2025.
ABSTRACT Background Primary sclerosing cholangitis (PSC) is a chronic liver disease characterised by inflammation and fibrosis of the bile ducts, conferring an increased risk of cholangiocarcinoma (CCA). However, detecting CCA early in PSC patients remains challenging due to the limited sensitivity of conventional diagnostic methods, including imaging ...
Maria Arechederra, Emil Bik, Carla Rojo, Jasmin Elurbide, María Elizalde, Beata Kruk, Maciej Krasnodębski, Jan Pertkiewicz, Sławomir Kozieł, Michał Grąt, Joanna Raszeja‐Wyszomirska, Maria Rullan, Gorka Alkorta‐Aranburu, Daniel Oyón, Maite G. Fernández‐Barrena, Lena S. Candels, Andrzej Białek, Łukasz Krupa, Kai M. Schneider, Jesús Urman, Pavel Strnad, Christian Trautwein, Piotr Milkiewicz, Marcin Krawczyk, Matías A. Ávila, Carmen Berasain   +25 more
wiley   +1 more source

Clinical course of pancreas cancer diagnosed after spleen-preserving distal pancreatectomy with borderline lesion: two case reports [PDF]

Korean Journal of Clinical Oncology
Distal pancreatectomy with splenectomy is considered the standard operation for pancreas tail and body cancer. However, splenectomy may be option for benign or low-grade malignant tumors including mucinous cystadenoma and intraductal papillary mucinous ...
Byeong Gwan Noh, Hyung Il Seo, Young Mok Park   +2 more
doaj   +1 more source

Unique Presentation of Giant Metastatic Microcystic Serous Adenocarcinoma of the Pancreas

Case Reports in Gastrointestinal Medicine, 2014
Tumors of the pancreas that contain substantial cystic components include mainly mucinous cystic neoplasm, intraductal papillary mucinous neoplasm, solid pseudopapillary tumor, and cystadenomas (which encompass microcystic, macrocystic/oligocystic, and ...
Cyriac Abby Philips, Chetan Ramesh Kalal, Chhagan Bihari, Amrish Sahney, KN Chandan Kumar, Archana Rastogi   +5 more
doaj   +1 more source

A Rare Case of Intraductal Papillary Mucinous Neoplasm of the Biliary Duct in a Patient with Prostate Adenocarcinoma

Case Reports in Gastroenterology, 2016
Intraductal papillary mucinous neoplasms (IPMNs) are mucin-producing papillary neoplasms of the pancreatic or biliary ductal system that exhibit variable cellular atypia and cause ductal dilation.
Ravish Parekh, Gregory Krol, Cyrus Piraka, Surinder Batra   +3 more
doaj   +1 more source

Folding of Pig Gastric Mucin Non-glycosylated Domains: A Discrete Molecular Dynamics Study [PDF]

arXiv, 2009
Mucin glycoprotein consist of tandem repeating glycosylated regions flanked by non-repetitive protein domains with little glycosylation. These non-repetitive domains are involved in the pH dependent gelation of gastric mucin, which is essential to protecting the stomach from autodigestion.
arxiv  

Pancreatic intraductal papillary mucinous neoplasm associated colloid carcinoma

Radiology Case Reports, 2021
Colloid carcinomas are rare pancreatic tumors characterized by the presence of mucin pools with scarce malignant cells. Most of these neoplasms arise from intestinal-type intraductal papillary mucinous neoplasms (IPMNs). We report a case of a 77-year-old
Beatriz Flor-de-Lima, MD, Patrícia S․ Freitas, MD, Nuno Couto, MD, Mireia Castillo-Martin, MD, PhD, Inês Santiago, MD, PhD   +4 more
doaj  

FDG-PET Findings of Intraductal Oncocytic Papillary Neoplasms of the Pancreas: Two Case Reports

Case Reports in Gastroenterology, 2012
Intraductal oncocytic papillary neoplasm (IOPN) of the pancreas is a rare pancreatic tumor. To date, there have been three case reports of IOPN which showed strong positivity on 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), raising the ...
Takashi Kato, Shuji Ikari, Kenji Hirata, Takuro Machida, Hideaki Nakamura, Takashi Meguro, Takayuki Morita, Toshiyuki Takahashi, Nagara Tamaki, Shoichi Horita   +9 more
doaj   +1 more source

Filovirus Glycoprotein Sequence, Structure and Virulence [PDF]

arXiv, 2014
Leading Ebola subtypes exhibit a wide mortality range, here explained at the molecular level by using fractal hydropathic scaling of amino acid sequences based on protein self-organized criticality. Specific hydrophobic features in the hydrophilic mucin-like domain suffice to account for the wide mortality range.
arxiv