Results 111 to 120 of about 38,020 (224)

Intrahepatic cholangiocarcinoma: current perspectives

OncoTargets and Therapy, 2017
Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy arising from the liver. ICC makes up about 10% of all cholangiocarcinomas. It arises from the peripheral bile ducts within the liver parenchyma, proximal to the secondary biliary radicals. Histologically, the majority of ICCs are adenocarcinomas. Only a minority of patients (15%)
Stefan Buettner, Jeroen L.A. van Vugt, Jan IJzermans, Bas Groot Koerkamp   +3 more
openaire   +4 more sources

Targeting Wnt3a and Loxl2 Synergistically Induces Ferroptosis in Liver Cancer Stem Cells and Suppresses Tumorigenesis

Cancer Science, EarlyView.
Using bioinformatic analysis, LCSC models, and transgenic mice, we demonstrate that co‐inhibition of Wnt3a and Loxl2 potently triggers ferroptosis and inhibits orthotopic liver tumorigenesis. The enhanced antitumor effect upon dual targeting, mediated through ZEB1 upregulation, highlights a promising combinatory approach against HCC.
Guanghui Ren, Qingwei Cong, Jing Wang, Wenyue Gao, Yunpeng Guan, Lianxin Zhu, Ying Zhu   +6 more
wiley   +1 more source

Cholangiocarcinoma in sclerosing cholangitis. The role of liver transplantation [PDF]

, 1989
Our experience with patients who underwent orthotopic liver transplantation for sclerosing cholangitis at the University of Pittsburgh Health Center between March 1980 and March 1988 is reported here.
Iwatsuki, S, Marino, IR, Starzl, TE, Stieber, AC   +3 more
core  

Radiation therapy for primary carcinoma of the extrahepatic biliary system. An analysis of 63 cases. [PDF]

, 1991
From 1976 to 1988, 63 patients received radiation therapy for primary cancers of the extrahepatic biliary system (eight gallbladder and 55 extrahepatic biliary duct). Twelve patients underwent orthotopic liver transplantation.
Carr, BI, Epstein, AH, Flickinger, JC, Iwatsuki, S, Starzl, TE   +4 more
core   +1 more source

Aquaporin‐1 differentiates intrahepatic cholangiocarcinoma from liver metastases of pancreatic ductal adenocarcinoma

Histopathology, EarlyView.
Differentiating intrahepatic CCA from PDAC metastatic to the liver is critical for the clinical management of patients with pancreatobiliary cancers. AQP1 has demonstrated an excellent discriminatory performance in this clinical scenario. Aims Differentiating intrahepatic cholangiocarcinoma (iCCA) from metastatic ductal adenocarcinoma of the pancreas ...
Leoncini Giuseppe, Barella Marco, Droz Dit Busset Michele, Gentili Marco, Bodini Beatrice, Ronchetti Simona, Cari Luigi, Mazzaferro Vincenzo   +7 more
wiley   +1 more source

Angiogenic miRNAs, the angiopoietin axis and related TIE2-expressing monocytes affect outcomes in cholangiocarcinoma [PDF]

, 2018
Background: Tumour angiogenesis is modulated on both an epigenetic and protein level and has potential implications for immune cell responses. However, the importance of related angiogenic biomarkers in cholangiocarcinoma (CCA) is unknown.
Atanasov, Georgi, Bahra, Marcus, Benzing, Christian, Brandl, Andreas, Dietel, Corinna, Feldbrügge, Linda, Jonas, Sven, Katou, Shadi, Krenzien, Felix, Pascher, Andreas, Pratschke, Johann, Reutzel-Selke, Anja, Robson, Simon C., Schierle, Katrin, Schmelzle, Moritz, Splith, Katrin, Wiltberger, Georg   +16 more
core   +1 more source

Standardized Approach for Laparoscopic Hemispheric Liver Resection for Segments 7 and 8

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Background We investigated whether the standardized “can‐opener method” surgical technique is an adequate surgical procedure for hemispheric hepatectomy in segments 7 and 8. Methods Forty‐two patients who underwent laparoscopic hemispheric liver resection for segments 7 and 8 using our standardized surgical technique were enrolled.
Ryoichi Miyamoto, Masahiro Shiihara, Mitsuru Watanabe, Jiro Shimazaki, Mitsugi Shimoda, Shuji Suzuki   +5 more
wiley   +1 more source

Recent Updates in the Imaging Diagnosis of Cholangiocarcinoma

대한영상의학회지, 2019
Cholangiocarcinoma is a disease entity with a wide spectrum of imaging, histological, and clinical features as well as treatment options. At present, imaging studies are essential for the detection, characterization, staging, and resectability assessment
Ijin Joo
doaj   +1 more source

Efficacy of Drainage Combining Endoscopic Retrograde Cholangiopancreatography With Endoscopic Ultrasound‐guided Biliary Drainage for Difficult‐to‐Control Cholangitis in Patients With Hilar Cholangiocarcinoma

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objectives Hilar cholangiocarcinoma often results in repeated early stent dysfunction and difficult‐to‐control cholangitis after drainage using endoscopic retrograde cholangiopancreatography (ERCP). In this study, we evaluated the effectiveness of additional drainage using endoscopic ultrasound‐guided biliary drainage (EUS‐BD) in patients with
Tomoki Ogata, Yusuke Kurita, Takamitsu Sato, Shin Yagi, Yu Honda, Takeshi Iizuka, Sho Hasegawa, Kunihiro Hosono, Noritoshi Kobayashi, Itaru Endo, Kensuke Kubota, Masato Yoneda, Atsushi Nakajima   +12 more
wiley   +1 more source

Identification of a novel anoikis-related gene signature to predict prognosis and tumor microenvironment in intrahepatic cholangiocarcinoma carcinoma

Discover Oncology
Background Intrahepatic cholangiocarcinoma is a malignant tumor of hepatobiliary epithelial cells. In recent years, its incidence has gradually increased.
Xuan Zhou, Bai Wei, Yan Wang, Mingjie Liu, Xiangru Guo, Yuting Duan   +5 more
doaj   +1 more source