Results 121 to 130 of about 29,547 (250)

Drug Interactions of Vebreltinib, a Novel Type I c‐Met Inhibitor, Coadministration With Rifampin or Itraconazole in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
Pharmacokinetic and drug–drug interaction evaluation of vebreltinib in healthy participants, showing decreased exposure with rifampin and increased exposure with itraconazole. ABSTRACT Vebreltinib is a novel, highly selective type I c‐Met inhibitor developed for treating non–small cell lung cancer (NSCLC) and glioma.
Jingcheng Chen, Jingxuan Wu, Yuqin Song, Jiangshuo Li, Linna li, Lijun Li, Yanhong Kong, Xiaofang Wu, Hang Yin, Mengyu Hou, Bingyan Wang, Qiannan Gao, Ran Li, Le Wu, Weizhe Xue, Ruihua Dong   +15 more
wiley   +1 more source

Advancements in Locoregional Therapies for Unresectable Intrahepatic Cholangiocarcinoma

Current Oncology
Intrahepatic cholangiocarcinoma is an aggressive malignancy with rising incidence and poor outcomes. This review examines recent advancements in locoregional therapies for unresectable intrahepatic cholangiocarcinoma, focusing on external beam ...
Conor D. J. O’Donnell, Umair Majeed, Michael S. Rutenberg, Kristopher P. Croome, Katherine E. Poruk, Beau Toskich, Zhaohui Jin   +6 more
doaj   +1 more source

Cholangiocarcinoma in Denmark: Time-trends in incidence and mortality

JHEP Reports
Background & Aims: Cholangiocarcinomas have a poor prognosis, and the incidence is rising in most countries. We examined time-trends in incidence and mortality in a nationwide Danish cohort.
Morten Daniel Jensen, Joe West, Britta Weber, Frank Viborg Mortensen, Peter Jepsen   +4 more
doaj   +1 more source

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

Advanced Science, Volume 13, Issue 32, 9 June 2026.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo, Ziqin Liu, Zimin Song, Dong Zhang, Cong Liang, Fei Fang, Kai Lei, Lina Wang, Weikang Chen, Shunli Shen, Ming Kuang, Xiaoxing Li, Jun Yu, Shiyan Wang, Lixia Xu   +14 more
wiley   +1 more source

Outcomes of intrahepatic cholangiocarcinoma after liver resection

, 2013
BACKGROUND & AIMS: Background and aims: The optimal surgical management for intrahepatic cholangiocarcinoma (IHC) is controversial especially in regard to the need for radical lymphadenectomy.
Tsang, SHY, Chan, ACY, Chok, KSH, Poon, RTP, Wong, TCL, Cheung, TT   +5 more
core   +1 more source

A Modular and Programmable Cas13d Platform for RNA Single Nucleotide Variant Detection

Advanced Science, Volume 13, Issue 32, 9 June 2026.
A scenario‐guided Cas13d platform enables configurable single nucleotide variant ribonucleic acid diagnostics through rule‐based guide design and ribonucleic acid binding domain engineering, supporting amplification‐free ultrasensitive detection and amplification‐coupled robust detection for accurate mutation classification in clinical tumor specimens.
Zeyu Wang, Jiahao Li, Zhuying Yue, Beixuan He, Wenhua Zhang, Zhen Fang, Qing Xia, Yingbin Liu, Yanjing Li   +8 more
wiley   +1 more source

Thyroid-Like Intrahepatic Cholangiocarcinoma: Report of a Case and Review of the Literature

, 2018
Intrahepatic cholangiocarcinoma is a relatively uncommon malignant neoplasm. We recently encountered an unusual case of intrahepatic cholangiocarcinoma that histologically resembled a thyroid carcinoma.
Xian-zong Ye, Li-juan Qu, Ying-hao Yu, Zhi-yong Zheng, Hanlin L. Wang, De-hua Zeng, Shao-hua Chen   +6 more
core   +1 more source

Comprehensive Genomic Profiles of Patients With Biliary Tract Cancer

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Purpose Biliary tract cancer (BTC) represents a heterogeneous disease with highly lethal malignancy and poor clinical outcomes. Here, we aimed to evaluate its genomic profiles to promote the development of precision medicine for BTC. Materials and Methods Genomic analysis of 134 BTC patients was performed by using targeted panel sequencing in ...
Xia Yang, Tao Zhu, Xiaotong Hu, Zhinong Jiang, Hongchuan Jin   +4 more
wiley   +1 more source

Acute Upper Gastrointestinal Bleeding is Associated With Poor Prognosis in Patients With Biliary Tract Cancer

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Aim Upper gastrointestinal bleeding (UGIB) is associated with an unfavorable outcome in cancer patients. In patients with biliary tract cancer (BTC), data on the incidence, management, and prognostic implications of UGIB are limited. This study investigated the prevalence, treatment efficacy, and prognostic factors associated with UGIB in BTC.
Jan Christoph Schumacher, Sonja Lang, Philipp Kasper, Anna Martin, Dirk Waldschmidt, Martin Bürger, Ulrich Töx, Christoph Neumann‐Haefelin, Gabriel Allo   +8 more
wiley   +1 more source

Intrahepatic cholangiocarcinoma: MRI and pathologic correlation in 14 patients

, 1997
Purpose: Our goal was to determine the MR features of intrahepatic cholangiocarcinoma and to correlate them with pathologic findings in a surgical series.
Zins, Marc, Denys, Alban, Van Beers, Bernard, Belghiti, Jacques, Delos, Monique, Flejou, Jean-Fraçois, Vilgrain, Valérie, Gautier, Anne-Laurence, Menu, Yves   +8 more
core   +1 more source