Results 111 to 120 of about 38,611 (262)

CD90 Promotes Gastric Cancer Progression by Regulating SLC1A5‐Mediated Glutamine Metabolism Through YY1

Cancer Science, EarlyView.
The CD90‐YY1‐SLC1A5 axis plays a significant role in gastric cancer. CD90 promotes the binding of YY1 to the SLC1A5 promoter. CD90 regulates SLC1A5‐mediated glutamine metabolism and ferroptosis. ABSTRACT CD90 (THY1) is a cell surface glycoprotein that plays a crucial role in the occurrence and development of various malignant tumors.
Zihua Zhou, Siyi Liu, Chenyu Zhang, Jun Deng, Lin Liang, Yanhong Zhou   +5 more
wiley   +1 more source

Recent Updates in the Imaging Diagnosis of Cholangiocarcinoma

대한영상의학회지, 2019
Cholangiocarcinoma is a disease entity with a wide spectrum of imaging, histological, and clinical features as well as treatment options. At present, imaging studies are essential for the detection, characterization, staging, and resectability assessment
Ijin Joo
doaj   +1 more source

Genome-wide expression patterns associated with oncogenesis and sarcomatous transdifferentation of cholangiocarcinoma [PDF]

, 2011
Background The molecular mechanisms of CC (cholangiocarcinoma) oncogenesis and progression are poorly understood. This study aimed to determine the genome-wide expression of genes related to CC oncogenesis and sarcomatous transdifferentiation.
Min-A Seol, In-Sun Chu, Mi-Jin Lee, Goung-Ran Yu, Xiang-Dan Cui, Baik-Hwan Cho, Eun-Kyung Ahn, Sun-Hee Leem, In-Hee Kim, Dae-Ghon Kim   +9 more
core   +1 more source

Irradiated Liver Cancer Cell Vaccine Transfected With GM‐CSF Induces Specific and Long‐Lasting Anti‐tumour Immunity Through the Synergistic Effect of Oxidised mtDNA and GM‐CSF

Cell Proliferation, EarlyView.
Song et al. developed an mGM‐CSF‐loaded, liver cancer cell‐based vaccine that potently activated dendritic cells and elicited tumour‐specific T cell responses. Mechanistically, radiation‐induced oxidative damage to mitochondrial DNA in cancer cells triggers the cGAS‐STING pathway in DCs, which synergizes with mGM‐CSF‐driven JAK2‐STAT3 signalling to ...
Zhiruo Song, Yujie Jiang, Yu Zhang, Danyi Ao, Chunjun Ye, Xiya Huang, Yingqiong Zhou, Hanle Yang, Ruolan Xia, Jiayuan Ai, Dandan Wan, Aiping Tong, Yuquan Wei, Xuemei He, Aqu Alu, Xiawei Wei   +15 more
wiley   +1 more source

VEGF‐Positive Mass‐Forming Intrahepatic Cholangiocarcinoma: New Subtype Based on Radiological and Molecular Pathological Analysis

Hepatology Research, EarlyView.
Radiological and molecular pathological investigation of hypervascular intrahepatic cholangiocarcinoma, typically a hypovascular tumor, revealed high VEGF expression, an increase in tumor‐associated arterial vessels, and a strong correlation with favorable prognosis.
Junya Tsuzaki, Naoto Kubota, Shigeyoshi Soga, Yasuhito Arai, Tatsuhiro Shibata, Minoru Esaki, Masahiro Jinzaki, Hidenori Ojima   +7 more
wiley   +1 more source

Identification of a novel anoikis-related gene signature to predict prognosis and tumor microenvironment in intrahepatic cholangiocarcinoma carcinoma

Discover Oncology
Background Intrahepatic cholangiocarcinoma is a malignant tumor of hepatobiliary epithelial cells. In recent years, its incidence has gradually increased.
Xuan Zhou, Bai Wei, Yan Wang, Mingjie Liu, Xiangru Guo, Yuting Duan   +5 more
doaj   +1 more source

Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma

Nature Communications, 2018
Hepatocellular-cholangiocarcinoma (H-ChC) is a rare subtype of liver cancer with features of hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Here, the authors utilize whole exome sequencing to highlight the monoclonal origin and stemness of
Anqiang Wang, Liangcai Wu, Jianzhen Lin, Longzhe Han, Jin Bian, Yan Wu, Simon C. Robson, Lai Xue, Yunxia Ge, Xinting Sang, Wenze Wang, Haitao Zhao   +11 more
doaj   +1 more source

Annual magnetic resonance cholangiopancreatography surveillance outcomes in individuals with primary sclerosing cholangitis

Internal Medicine Journal, EarlyView.
Abstract Background Annual surveillance for cholangiocarcinoma using magnetic resonance cholangiopancreatography (MRCP) has been recommended in primary sclerosing cholangitis (PSC) to improve the associated dismal outcomes. However, data are limited. Aims To compare the outcomes of surveillance versus non‐surveillance in patients with PSC.
Gary Dezhi Zhang, Chloe Attree, Nazneen Irani, Jonathan Tibballs, John Ferguson, Luis Calzadilla Bertot, Michael Wallace, Briohny Smith, George Garas, Gary Jeffrey, Leon Anton Adams, Gerry MacQuillan   +11 more
wiley   +1 more source

Case report: Rare observation of thyroid-like cholangiocarcinoma

Frontiers in Medicine
Intrahepatic cholangiocarcinoma is a highly malignant tumor with a poor prognosis. Radical surgical resection remains the “gold standard” for improving patient outcomes; however, only a minority of patients qualify for this approach.
Ekaterina Bondarenko, Dmitriy Kalinin, Liliya Urusova, Dariya Pastukhova, Rustam Salimkhanov, Natalia Mokrysheva   +5 more
doaj   +1 more source

Intrahepatic Cholangiocarcinoma: Epidemiological Trends, Risk Factors, Diagnostic Challenges, and Advances in Personalized Therapy—A Comprehensive Review

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Intrahepatic cholangiocarcinoma (iCCA) ranks as the second most common primary liver cancer, compared to about 20% of cases. Its global incidence has climbed over the past four decades, yet early detection remains indefinable due to its asymptomatic nature. Five‐year survival rate of approximately is under 10%.
Yaqoob Muhammad, YuZhu Jin, Kai Luo, He Bai, Xudong Zhang, Xu Sun, Zahoor Maheen, Ali Tanveer, Saeed Muddasar Muhammad, Jialin Qu, Guixin Zhang   +10 more
wiley   +1 more source