Results 41 to 50 of about 96,641 (177)

Futibatinib, an investigational agent for the treatment of intrahepatic cholangiocarcinoma: evidence to date and future perspectives

Expert Opinion on Investigational Drugs, 2020
Introduction Biliary tract cancers (BTCs) are poor prognosis malignancies usually classified in intrahepatic cholangiocarcinoma (iCCA), extrahepatic cholangiocarcinoma, gallbladder cancer, and ampulla of Vater cancer.
A. Rizzo, A. Ricci, G. Brandi
semanticscholar   +1 more source

The immunogenomic landscape of resected intrahepatic cholangiocarcinoma

Hepatology, 2021
Cholangiocarcinoma (CCA) is a deadly and highly therapy‐refractory cancer of the bile ducts, with early results from immune checkpoint blockade trials showing limited responses.
F. Carapeto, B. Bozorgui, R. Shroff, Sharmeen Chagani, L. S. Solis Soto, W. Foo, I. Wistuba, F. Meric-Bernstam, A. Shalaby, M. Javle, Anil Korkut, L. Kwong   +11 more
semanticscholar   +1 more source

Cost‐Effective Identification of Hepatocellular Carcinoma from Cirrhosis or Chronic Hepatitis Virus Infection Using Eight Methylated Plasma DNA Markers

Advanced Science, EarlyView.
Early detection of hepatocellular carcinoma in patients with liver cirrhosis and/or hepatitis virus B/C infection improves survival. Through marker discovery, 8 methylated DNA markers are identified and a logistic regression model (COMET‐LR) is built in the training set, which achieved 90.0% sensitivity at 97.4% specificity in the validation set.
Tian Yang, Mingda Wang, Nanya Wang, Mingxin Pan, Yu Xu, Qiancheng You, Lanqing Yao, Jiahao Xu, Lihui Gu, Xiaodong Sun, Lei Zhang, Jiayue Xu, Bingsi Li, Guoqiang Wang, Shangli Cai, Guoyue Lv, Feng Shen   +16 more
wiley   +1 more source

Dissecting the Spatial and Single‐Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer

Advanced Science, EarlyView.
A single‐cell and spatial transcriptional atlas reveals the architecture of human gastric cancer stem cell (CSC) niche and the developmental trajectory of CSCs. These CSCs interact with immunosuppressive immune cells thereby constructing immune‐suppressive niche, and inflammatory cancer‐associated fibroblast (iCAFs) to enhance stemness through ...
Guangyu Zhang, Xin Zhang, Wenting Pan, Xizhao Chen, Lingfei Wan, Chunjie Liu, Yuting Yong, Yue Zhao, Shuli Sang, Lihua Zhang, Sheng Yao, Yushu Guo, Mingmei Wang, Xinhui Wang, Guangdun Peng, Xinlong Yan, Yanchun Wang, Min Zhang   +17 more
wiley   +1 more source

Primary liver cancer classification from routine tumour biopsy using weakly supervised deep learning [PDF]

JHEP Reports, Volume 6, Issue 3, 2024
The diagnosis of primary liver cancers (PLCs) can be challenging, especially on biopsies and for combined hepatocellular-cholangiocarcinoma (cHCC-CCA). We automatically classified PLCs on routine-stained biopsies using a weakly supervised learning method.
arxiv   +1 more source

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source

AI-based Agents for Automated Robotic Endovascular Guidewire Manipulation [PDF]

arXiv, 2023
Endovascular guidewire manipulation is essential for minimally-invasive clinical applications (Percutaneous Coronary Intervention (PCI), Mechanical thrombectomy techniques for acute ischemic stroke (AIS), or Transjugular intrahepatic portosystemic shunt (TIPS)).
arxiv  

Association between surgical difficulty and tumor location based on subsegments of the Glisson branches in laparoscopic liver resection

Annals of Gastroenterological Surgery, EarlyView.
Our study validates the need for a more detailed and accurate tumor location scoring system within the IWATE criteria. The proposed classification based on subsegmental Glisson branches provides a sophisticated tool for assessing LLR difficulty. By providing a more detailed assessment, this new system has the potential to enhance surgical planning ...
Taisuke Imamura, Yusuke Yamamoto, Ryo Morimura, Hisashi Ikoma, Tomohiro Arita, Hirotaka Konishi, Atsushi Shiozaki, Takeshi Kubota, Hitoshi Fujiwara, Eigo Otsuji   +9 more
wiley   +1 more source

Updated risk prediction model for pancreaticoduodenectomy using data from the National Clinical Database in Japan

Annals of Gastroenterological Surgery, EarlyView.
The calibration plots of the updated risk models for the endpoints were analyzed in each cohort. The predicted probability of each endpoint matched the observed probability in the development and validation cohorts. Abstract Aim Risk prediction models for mortality, severe postoperative complications, and postoperative pancreatic fistula in patients ...
Masamichi Mizuma, Hideki Endo, Hiroyuki Yamamoto, Mitsuhiro Shimura, Masahiro Iseki, Michiaki Unno, Taro Oshikiri, Yoshihiro Kakeji, Ken Shirabe   +8 more
wiley   +1 more source

Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan, Jinling Song, Yuqing Ren, Yuyuan Zhang, Yuhao Ba, Peng Luo, Quan Cheng, Hui Xu, Siyuan Weng, Anning Zuo, Shutong Liu, Xinwei Han, Jinhai Deng, Zaoqu Liu   +13 more
wiley   +1 more source