Results 41 to 50 of about 24,968 (201)

Lenvatinib Combined With a PD-1 Inhibitor as Effective Therapy for Advanced Intrahepatic Cholangiocarcinoma

Frontiers in Pharmacology, 2022
Background: Lenvatinib combined with a PD-1 inhibitor has obtained a satisfactory antitumor effect in several solid tumors. However, the efficacy and tumor response of lenvatinib with a PD-1 inhibitor in advanced intrahepatic cholangiocarcinoma still ...
Lulu Xie, Jingzheng Huang, Linling Wang, Wenrui Ren, Hao Tian, Anhong Hu, Jun Liang, Yuqing Jiao, Yali Li, Qunfang Zhou, Wenjing Zhang   +10 more
doaj   +1 more source

Serum Markers of Intrahepatic Cholangiocarcinoma [PDF]

Disease Markers, 2013
Cholangiocarcinoma (CCA) is a relatively rare type of primary liver cancer that originates in the bile duct epithelium. It is an aggressive malignancy typified by unresponsiveness to chemotherapy and radiotherapy. Despite advances in radiologic techniques and laboratory diagnostic test, the diagnosis of CCA remains highly challenging.
MALAGUARNERA, GIULIA ANNA MARIA, PALADINA, ISABELLA, GIORDANO, MARIA, MALAGUARNERA, MICHELE, BERTINO, Gaetano, Berretta, M.   +5 more
openaire   +2 more sources

Isolation of cancer‐associated fibroblasts and its promotion to the progression of intrahepatic cholangiocarcinoma

Cancer Medicine, 2018
Intrahepatic cholangiocarcinoma is a highly fatal tumor characterized by an abundant stromal environment. Cancer‐associated fibroblasts play key roles in tumor growth and invasiveness and have been regarded as a potential therapeutic target.
Meng Sha, Seogsong Jeong, Bi‐jun Qiu, Ying Tong, Lei Xia, Ning Xu, Jian‐jun Zhang, Qiang Xia   +7 more
doaj   +1 more source

Mass-forming intrahepatic cholangiocarcinoma presenting with painful obstructive hemobilia

Journal of the Belgian Society of Radiology, 2014
We report a very rare case of acute obstructive hemobilia caused by bleeding of a mass-forming intrahepatic cholangiocarcinoma in a 75-year old man. The prompt complete emergency diagnosis was made by ultrasound and confirmed by MDCT.
B Coulier, Ph Maldague, A Ramboux, I Gielen   +3 more
doaj   +1 more source

Clear cell papillary cholangiocarcinoma: A case report with review of literature

Indian Journal of Pathology and Microbiology, 2014
Clear cell papillary cholangiocarcinoma is a rare variant of intrahepatic cholangiocarcinoma with only nine reported cases in the literature. This tumor needs to be differentiated from clear cell variant of hepatocellular carcinoma and other metastatic ...
Rachna Khera, Shantveer G Uppin, Megha S Uppin, Challa Sundaram   +3 more
doaj   +1 more source

INTRAHEPATIC CHOLANGIOCARCINOMA

Clinical and Experimental Morphology
Intrahepatic cholangiocarcinoma (ICC) is a rare but aggressive malignancy arising from the epithelial cells of the intrahepatic bile ducts. The disease is characterized by complex diagnosis, high mortality, and limited therapeutic options at advanced stages.
Banina E., Burgoci S.
  +6 more sources

Does resection improve overall survival for intrahepatic cholangiocarcinoma with nodal metastases?

Surgery Open Science, 2020
Background: The potential benefit of surgical resection of intrahepatic cholangiocarcinoma in patients with locoregionally advanced disease has not been definitively determined.
Patrick J. Sweigert, MD, Emanuel Eguia, MD, MS, MHA, Haroon Janjua, MS, Sean P. Nassoiy, DO, MS, Lawrence M. Knab, MD, Gerard Abood, MD, MS, Paul C. Kuo, MD, MS, MBA, Marshall S. Baker, MD, MBA   +7 more
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Intra-arterial PSMA injection using hepatic arterial infusion pump in intrahepatic cholangiocarcinoma: a proof-of-concept study

European Radiology Experimental
Prostate-specific membrane antigen (PSMA) targeted tracers show increased uptake in several malignancies, indicating a potential for peptide radioligand therapy. Intra-arterial injection of radiotracers can increase the therapeutic window.
Mara Marieke Katrien Veenstra, Erik Vegt, Marcel Segbers, Stijn Franssen, Bas Groot Koerkamp, Frederik Anton Verburg, Maarten Guillaume Josephus Thomeer   +6 more
doaj   +1 more source

Gut‐Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction‐Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion

Advanced Science, EarlyView.
Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu, Zun Fan, Zhen Liu, Lei Qin, Xin Zhao   +4 more
wiley   +1 more source