Tumor Biology, 2017 The incidence rate of intrahepatic cholangiocarcinoma is rising, and treatment options are limited. Therefore, new biological markers of intrahepatic cholangiocarcinoma are needed.
Ze-Wu Meng +4 more
doaj +1 more source
Atmospheric pressure plasma jets applied to cancerology: correlating electrical configurations with in vivo toxicity and therapeutic efficiency [PDF]
Journal of Physics D: Applied Physics, Vol. 52, Issue 24, 2019, 2019 Two atmospheric pressure plasma jet devices - a plasma gun and a plasma Tesla jet - are compared in terms of safety and therapeutic efficiency to reduce the tumor volume progression of cholangiocarcinoma, i.e. a rare and very aggressive cancer emerging in biliary tree. For this, a three steps methodology is carried out.
arxiv +1 more source
The FXR agonist obeticholic acid inhibits the cancerogenic potential of human cholangiocarcinoma [PDF]
, 2019 Cholangiocarcinoma (CCA) is an aggressive cancer with high resistance to chemotherapeutics. CCA is enriched in cancer stem cells, which correlate with aggressiveness and prognosis.
Adorini, L. +19 more
core +3 more sources
EPIC-Survival: End-to-end Part Inferred Clustering for Survival Analysis, Featuring Prognostic Stratification Boosting [PDF]
arXiv, 2021 Histopathology-based survival modelling has two major hurdles. Firstly, a well-performing survival model has minimal clinical application if it does not contribute to the stratification of a cancer patient cohort into different risk groups, preferably driven by histologic morphologies.
arxiv
H3 histamine receptor-mediated activation of protein kinase calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo [PDF]
, 2009 Histamine regulates functions via four receptors (HRH1, HRH2, HRH3, and HRH4). The D-myo-inositol 1,4,5-trisphosphate (IP(3))/Ca(2+)/protein kinase C (PKC)/mitogen-activated protein kinase pathway regulates cholangiocarcinoma growth.
A. Vetuschi +13 more
core +1 more source
A deep learning pipeline for localization, differentiation, and uncertainty estimation of liver lesions using multi-phasic and multi-sequence MRI [PDF]
arXiv, 2021 Objectives: to propose a fully-automatic computer-aided diagnosis (CAD) solution for liver lesion characterization, with uncertainty estimation. Methods: we enrolled 400 patients who had either liver resection or a biopsy and was diagnosed with either hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma, or secondary metastasis, from 2006 ...
arxiv
Intrahepatic Sarcomatoid Cholangiocarcinoma [PDF]
Journal of Oncology, 2010 Intrahepatic sarcomatoid cholangiocarcinoma is a rare but an aggressive variant of cholangiocarcinoma with a very poor prognosis. We report the first caucasian patient who presented with a rapidly enlarging liver mass requiring hepatic resection. Detailed histopathological analyses including immunohistochemistry and electron microscopy confirmed ...
Talal Mansy +5 more
openaire +1 more source
Cancer Medicine, 2018 Intrahepatic cholangiocarcinoma is a highly fatal tumor characterized by an abundant stromal environment. Cancer‐associated fibroblasts play key roles in tumor growth and invasiveness and have been regarded as a potential therapeutic target.
Meng Sha +7 more
doaj +1 more source
Serum micrornas as novel biomarkers for primary sclerosing cholangitis and cholangiocarcinoma [PDF]
, 2016 The diagnosis of primary sclerosing cholangitis (PSC) is difficult due to the lack of sensitive and specific biomarkers, as is the early diagnosis of cholangiocarcinoma (CC), a complication of PSC.
Alpini, Gianfranco +17 more
core +2 more sources
Serum Markers of Intrahepatic Cholangiocarcinoma [PDF]
Disease Markers, 2013 Cholangiocarcinoma (CCA) is a relatively rare type of primary liver cancer that originates in the bile duct epithelium. It is an aggressive malignancy typified by unresponsiveness to chemotherapy and radiotherapy. Despite advances in radiologic techniques and laboratory diagnostic test, the diagnosis of CCA remains highly challenging.
MALAGUARNERA, GIULIA ANNA MARIA +5 more
openaire +2 more sources