Results 71 to 80 of about 38,611 (262)

Natural History and Prognostic Factors of Advanced Cholangiocarcinoma without Surgery, Chemotherapy, or Radiotherapy: A Large-Scale Observational Study

Gut and Liver, 2009
Background/AimsWe aimed to evaluate survival time and prognostic factors in patients with advanced unresectable cholangiocarcinoma who have not received surgery, chemotherapy, or radiotherapy.Methods : A total of 1,377 patients, who were diagnosed with ...
doaj   +1 more source

Imaging features of intrahepatic cholangiocarcinoma mimicking a liver abscess: an analysis of 8 cases

BMC Gastroenterology, 2021
Background In rare cases, intrahepatic cholangiocarcinoma can present as a pyogenic liver abscess and are often misdiagnosed. This study aimed to analyze the imaging features of intrahepatic cholangiocarcinoma mimicking a pyogenic liver abscess.
Manrong Liu, Jiong Chen, Ruisui Huang, Jianning Huang, Lin Li, Yunqian Li, Mi Qin, Wenqi Qin, Haiyang Nong, Ke Ding   +9 more
doaj   +1 more source

Impact of Recanalization on Liver Hypertrophy after Portal Vein Embolization and the Role of Re‐Embolization

Annals of Gastroenterological Surgery, EarlyView.
This retrospective study of 249 patients undergoing hepatectomy after right portal vein embolization (PVE) demonstrated that major recanalization–defined as recanalization more than one segment within the embolized liver–was associated with impaired regeneration of the future liver remnant (FLR).
Masao Uemura, Shimpei Otsuka, Ryo Ashida, Katsuhisa Ohgi, Mihoko Yamada, Rui Sato, Takeshi Aramaki, Akifumi Notsu, Katsuhiko Uesaka, Teiichi Sugiura   +9 more
wiley   +1 more source

The preoperative prognostic value of the radiomics nomogram based on CT combined with machine learning in patients with intrahepatic cholangiocarcinoma

World Journal of Surgical Oncology, 2021
Background Intrahepatic cholangiocarcinoma is an aggressive liver carcinoma with increasing incidence and mortality. A good auxiliary prognostic prediction tool is desperately needed for the development of treatment strategies.
Youyin Tang, Tao Zhang, Xianghong Zhou, Yunuo Zhao, Hanyue Xu, Yichun Liu, Hang Wang, Zheyu Chen, Xuelei Ma   +8 more
doaj   +1 more source

Defining Long-Term Survivors Following Resection of Intrahepatic Cholangiocarcinoma [PDF]

, 2017
BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is an aggressive primary tumor of the liver. While surgery remains the cornerstone of therapy, long-term survival following curative-intent resection is generally poor.
Aldrighetti, L, Alexandrescu, S, Bagante, F, Bauer, TW, Groot Koerkamp, B, Guglielmi, A, Itaru, E, Maithel, SK, Martel, G, Pawlik, TM, Pinto Marques, H, Poultsides, GA, Pulitano, C, Shen, F, Soubrane, O, Spolverato, G, Weiss, M   +16 more
core   +2 more sources

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Patterns of chromosomal copy-number alterations in intrahepatic cholangiocarcinoma [PDF]

, 2015
International audienceBackground: Intrahepatic cholangiocarcinomas (ICC) are relatively rare malignant tumors associated with a poor prognosis. Recent studies using genome-wide sequencing technologies have mainly focused on identifying new driver ...
Broët, Philippe, Camilleri-Broët, Sophie, Campos dos Santos, Cedália Rosane, Carpentier, Wassila, Castaing, Denis, Dalmasso, Cyril, Duclos-Vallée, Jean-Charles, Guettier, Catherine, Vendramini Borelli, Wyllians   +8 more
core   +3 more sources

Differentiating the Clinical and Variant Spectrum of Hardikar Syndrome From Other MED12‐Related Developmental Disorders

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The rare X‐linked female‐restricted Hardikar syndrome (HDKR, OMIM # 301068) is characterized by multiple congenital anomalies including orofacial clefts, gastrointestinal, genitourinary, and cardiac anomalies, but cognitive and neurobehavioral development is rarely impaired.
Tinne Warmoeskerken, Miel Theunis, Kris Van den Bogaert, Koenraad Devriendt, Jeroen Breckpot   +4 more
wiley   +1 more source

Pathology of intrahepatic cholangiocarcinoma [PDF]

HepatoBiliary Surgery and Nutrition, 2017
Intrahepatic cholangiocarcinoma (iCC) is a primary carcinoma of the liver with increasing significance and major pathogenic, clinical and therapeutic challenges. Classically, it arises from malignant transformation of cholangiocytes bordering small portal bile duct (BD) to second-order segmental large BDs. It has three major macroscopic growth pattern [
Vijgen, Sandrine Elisabeth V, Terris, Benoit, Rubbia-Brandt, Laura   +2 more
openaire   +3 more sources

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source