Results 81 to 90 of about 96,641 (177)

Structure of the Fab fragment of a humanized 5E5 antibody to a cancer‐specific Tn‐MUC1 epitope

Acta Crystallographica Section D, EarlyView.
The structure of the humanized Fab from murine monoclonal antibody 5E5 specific for tumor antigen Tn‐MUC1 has been determined to 1.57 Å resolution. The humanization process has imposed changes in the framework regions of the Fv which may have affected the Vh–Vl interface.The structure of the humanized Fab from murine monoclonal antibody 5E5 specific ...
Wei Li, Ulla Mandel, Henk van Faassen, Matthew J. Parker, Max S. G. Legg, Greg Hussack, Henrik Clausen, Stephen V. Evans   +7 more
wiley   +1 more source

Mass‐forming intrahepatic cholangiocarcinoma: treatment outcomes after curative‐intent resection in an Australian tertiary referral hospital

ANZ Journal of Surgery, EarlyView.
The study provides results from 25 years of experience in curative‐intent liver resections for patients with mass‐forming intrahepatic cholangiocarcinoma in Australia. Liver resection can offer a significant chance for prolonged survival, however, the treatment of this rare disease still presents great challenges.
Sander R. W. J. Martens, Nazim Bhimani, Cameron Gofton, Kai M. Brown, Philip R. de Reuver, Thomas J. Hugh   +5 more
wiley   +1 more source

Second Opinion Referrals of Cancer Patients in Japan—A Nationwide Study

Cancer Science, EarlyView.
We investigated SO referrals, including delays in initiating care, using data from nationwide hospital‐based cancer registries and 2018–2020 Diagnosis Procedure Combination (DPC) survey in Japan. We identified differences in the mean time from diagnosis to treatment initiation between patients who sought SO and those who did not.
Mieko Takasawa, Norihiro Teramoto, Natsumi Yamashita, Takahiro Higashi   +3 more
wiley   +1 more source

Towards Real-time Intrahepatic Vessel Identification in Intraoperative Ultrasound-Guided Liver Surgery [PDF]

MICCAI 2024, Oct 2024, Marrakech, Morocco
While laparoscopic liver resection is less prone to complications and maintains patient outcomes compared to traditional open surgery, its complexity hinders widespread adoption due to challenges in representing the liver's internal structure. Laparoscopic intraoperative ultrasound offers efficient, cost-effective and radiation-free guidance.
arxiv  

Comparison of fully versus partially covered metal stents in endoscopic ultrasound‐guided hepaticogastrostomy for malignant biliary obstruction (with video)

Digestive Endoscopy, EarlyView.
Background Endoscopic ultrasound‐guided hepaticogastrostomy (EUS‐HGS) using a fully covered metal stent (FCMS) or partially covered metal stent (PCMS) is performed to manage unresectable malignant biliary obstruction (MBO) following unsuccessful endoscopic retrograde cholangiopancreatography.
Sung Hyun Cho, Seong Je Kim, Tae Jun Song, Dongwook Oh, Dong‐Wan Seo   +4 more
wiley   +1 more source

Endoscopic management of primary sclerosing cholangitis

Digestive Endoscopy, EarlyView.
Primary sclerosing cholangitis (PSC) is a progressive autoimmune hepatobiliary disease characterized by fibrotic strictures in the bile ducts, leading to chronic cholestasis and cirrhosis. Magnetic resonance cholangiopancreatography (MRCP) is a noninvasive method for evaluating the condition of the bile ducts, and has high sensitivity and specificity ...
Suguru Mizuno, Yoshihito Uchida, Satsuki Ando, Masamitsu Nakao, Kayoko Sugawara, Nobuaki Nakayama, Yukinori Imai, Tomoaki Tomiya, Satoshi Mochida   +8 more
wiley   +1 more source

Single-cell atlas of tumor cell evolution in response to therapy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

Journal of Hepatology, 2021
Lichun Ma, Limin Wang, Subreen A Khatib, C. Chang, S. Heinrich, D. Dominguez, M. Forgues, J. Candia, M. Hernandez, Michael Kelly, Yongmei Zhao, Bao Tran, Jonathan M. Hernandez, Jeremy L. Davis, D. Kleiner, B. Wood, T. Greten, X. Wang   +17 more
semanticscholar   +1 more source

Multicenter observational study to characterize fibroblast growth factor receptor 2 fusions or rearrangements in patients with advanced/metastatic cholangiocarcinoma

Hepatology Research, EarlyView.
In this study, we assessed patients with cancer of the liver bile ducts (intrahepatic cholangiocarcinoma) or cancer in bile ducts just outside the liver (perihilar cholangiocarcinoma) to see what factors were most commonly found in patients with fusions (and/or rearrangements) of the FGFR2 gene, a prominent target in bile duct cancer. Overall, we found
Tomoyuki Satake, Chigusa Morizane, Hiroyuki Isayama, Akio Katanuma, Masato Endo, Noritoshi Kobayashi, Yasushi Kojima, Shoji Kubo, Saburo Matsubara, Takeshi Shiraishi, Takashi Ohta, Tadashi Uwagawa, Shingo Kobayashi, Takatoshi Sahara, Setsuo Funasaka, Hiroki Ikezawa, Takuji Okusaka   +16 more
wiley   +1 more source

Diagnostic Yield of a Novel 11‐Fr Digital Cholangioscope for Indeterminate Biliary Disease Using Macroscopic‐On‐Site Evaluation: Prospective Comparative Study

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aim A novel 11‐Fr digital cholangioscope (eyeMAX) has recently become available. However, a prospective comparative study of the diagnostic yield of the eyeMAX and of a conventional cholangioscope (SpyGlass DS II) has not been reported.
Takeshi Ogura, Saori Ueno, Akitoshi Hakoda, Ahmad F. Aboelezz, Atsushi Okuda, Nobu Nishioka, Jun Sakamoto, Jun Matsuno, Yuki Uba, Mitsuki Tomita, Nobuhiro Hattori, Junichi Nakamura, Kimi Bessho, Hiroki Nishikawa   +13 more
wiley   +1 more source

N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression.

Molecules and Cells, 2021
Zihao Dai, Haining Liu, Junbin Liao, Cheng Huang, Xiaoxue Ren, Wanjie Zhu, Shenghua Zhu, B. Peng, Shao-Qiang Li, Jiaming Lai, L. Liang, Lixia Xu, S. Peng, Shuibin Lin, M. Kuang   +14 more
semanticscholar   +1 more source