Results 11 to 20 of about 1,053 (95)
S‐Adenosyl‐d‐Methionine as a Non‐Physiological Substrate for a Wide Range of SAM‐Dependent Enzymes
ChemBioChem, Volume 27, Issue 14, 29 July 2026.From methylation and cyclisation to radical chemistry, diverse enzyme classes utilise the non‐canonical cofactor d‐SAM. These findings reveal an unexpected tolerance of SAM‐dependent catalysis towards inversion of the methionine Cα stereocentre. The ability of SAM‐dependent enzymes to accept S‐adenosyl‐d‐methionine [d‐SAM, (SS,RCα)‐SAM] instead of the ...
Philipp Germer +17 more
wiley +1 more source
Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 4, July 2026.ABSTRACT Plant‐based antioxidants are widely incorporated into foods to retard oxidative deterioration and to deliver health‐related benefits. Yet, their in‐product and in vivo performance frequently diverges from predictions based on solution‐phase chemical assays, because matrix interactions, processing history, and host metabolism reshape both ...
Márcio Vargas‐Ramella +6 more
wiley +1 more source
Discovery of pseudobaptigenin synthase in fungal‐infected Trifolium pratense roots
The Plant Journal, Volume 127, Issue 1, July 2026.Significance Statement The discovery of pseudobaptigenin synthase in red clover (CYP76F319), catalyzing the formation of a methylenedioxy bridge to convert calycosin to pseudobaptigenin. The integration of metabolomic and transcriptomic datasets to describe the defense response in red clover roots to hemibiotrophic and necrotrophic fungi.
Lee Marie Raytek +3 more
wiley +1 more source
Developing unnatural functions and optimizing catalytic properties of enzymes are challenging tasks that require extensive engineering and screening of biocatalysts. In this study, we report the first example of enantiocomplementary intramolecular crossed aldehyde-ketone benzoin cyclizations catalyzed by benzaldehyde lyase.
Ling Yu, Zhijun Song
openaire +1 more source
MccB‐catalyzed C‐terminal Thioesterification for Protein Bioconjugation
Current Protocols, Volume 6, Issue 6, June 2026.Abstract Protein bioconjugation enables the installation of functional groups, probes, and payloads that cannot be genetically encoded, thereby enabling the study and manipulation of biological systems. An important class of intermediates in protein bioconjugation is C‐terminal protein α‐thioesters, which are kinetically stable yet thermodynamically ...
Di Yang, Amy M. Weeks
wiley +1 more source
New Plant Protection, Volume 3, Issue 2, June 2026.This review highlights how Phytophthora sojae utilizes unconventional lineage‐specific signaling networks, including unique G protein‐coupled receptor fusions, expanded kinases, and rapidly evolving effectors, to infect soybeans. Understanding these divergent molecular paradigms reveals critical vulnerabilities in this destructive pathogen, offering ...
Min Qiu +4 more
wiley +1 more source
New Plant Protection, Volume 3, Issue 2, June 2026.Dapple apple and scar skin apple diseases are closely associated with suppression of anthocyanin biosynthesis and enhancement of suberin biosynthesis. Apple scar skin viroid (ASSVd) infection represses anthocyanin biosynthesis in apple callus. Abstract Apple scar skin viroid (ASSVd) causes dapple and scar skin apple diseases, posing serious threats to ...
Lingzhu He +9 more
wiley +1 more source
Chitosan–Alginate Polyelectrolyte Systems: From Classical Release Models to the D‐PARMO Framework
Macromolecular Materials and Engineering, Volume 311, Issue 5, May 2026.Classical empirical models fail to predict the dynamic in vivo behavior of chitosan‐alginate nanocarriers. Bridging this translational gap, the novel D‐PARMO framework replaces purely descriptive curve‐fitting with a mechanistically informed operational model.
Parastoo Rekab, Akeem Adeyemi Oladipo
wiley +1 more source
Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions
MedComm, Volume 7, Issue 5, May 2026.We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu +8 more
wiley +1 more source
Environmental and Molecular Mutagenesis, Volume 67, Issue 4, April 2026.ABSTRACT Alternative DNA structure‐forming (i.e., non‐B) sequences such as H‐DNA‐forming sequences are enriched at chromosomal translocation hotspots in human cancer genomes, underscoring their role in genomic instability. H‐DNA is particularly susceptible to DNA damage by reactive oxygen species (ROS), a common byproduct from both endogenous ...
Alex W. Klattenhoff +4 more
wiley +1 more source