Results 21 to 30 of about 1,068 (106)

Purification and kinetic properties of elisabethatriene synthase from the coral Pseudopterogorgia elisabethae

open access: yes, 2006
The Bahamian octocoral Pseudopterogorgia elisabethae is the source of pseudopterosins, diterpene glycosides with potent anti-inflammatory activity.

core   +1 more source

Conception, synthèse et études biologiques de nouveaux inhibiteurs saccharidiques du métabolisme bactérien

open access: yes, 2006
This work describes the design, the synthesis and the biological studies of saccharadic inhibitors of two bacterial phosphoenolpyruvate lyases, KDO8PS and DAH7PS. Their structures are based on an extensive study of recent biochemical and biological data.
Barthes, Nicolas
core   +1 more source

MccB‐catalyzed C‐terminal Thioesterification for Protein Bioconjugation

open access: yesCurrent Protocols, Volume 6, Issue 6, June 2026.
Abstract Protein bioconjugation enables the installation of functional groups, probes, and payloads that cannot be genetically encoded, thereby enabling the study and manipulation of biological systems. An important class of intermediates in protein bioconjugation is C‐terminal protein α‐thioesters, which are kinetically stable yet thermodynamically ...
Di Yang, Amy M. Weeks
wiley   +1 more source

Chitosan–Alginate Polyelectrolyte Systems: From Classical Release Models to the D‐PARMO Framework

open access: yesMacromolecular Materials and Engineering, Volume 311, Issue 5, May 2026.
Classical empirical models fail to predict the dynamic in vivo behavior of chitosan‐alginate nanocarriers. Bridging this translational gap, the novel D‐PARMO framework replaces purely descriptive curve‐fitting with a mechanistically informed operational model.
Parastoo Rekab, Akeem Adeyemi Oladipo
wiley   +1 more source

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

open access: yesMedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu   +8 more
wiley   +1 more source

Strukturen und molekulare Mechanismen von Chorismatasen und deren Bedeutung für weitere Chorismat-umsetzende Enzyme

open access: yes, 2014
Chorismat ist ein wichtiger Verzweigungspunkt zwischen Primär- und Sekundärmetabolismus in Bakterien, Pflanzen und Pilzen. Verschiedene Chorismat-umsetzende Enzyme katalysieren die Bildung wichtiger, häufig chiraler oder aromatischer Moleküle, die häufig
Hubrich, Florian
core   +1 more source

Oxidative DNA Damage Exacerbates the Mutagenic Potential of Alternative DNA Structures via Altered DNA Repair Processing

open access: yesEnvironmental and Molecular Mutagenesis, Volume 67, Issue 4, April 2026.
ABSTRACT Alternative DNA structure‐forming (i.e., non‐B) sequences such as H‐DNA‐forming sequences are enriched at chromosomal translocation hotspots in human cancer genomes, underscoring their role in genomic instability. H‐DNA is particularly susceptible to DNA damage by reactive oxygen species (ROS), a common byproduct from both endogenous ...
Alex W. Klattenhoff   +4 more
wiley   +1 more source

Harnessing Free Radical Scavenging Potential of Caffeic Acid as a Nutraceutical—A Review

open access: yesFood Safety and Health, Volume 4, Issue 2, Page 327-342, April 2026.
Caffeic acid has emerged as a promising bioactive molecule with multiple pharmacological properties, including antioxidant, antimicrobial, anti‐inflammatory, organ protective properties and metal‐chelating ability. This review emphasizes the dietary sources, structural characteristic, molecular mechanism underlying health promoting effects of caffeic ...
Pavitra Behra   +2 more
wiley   +1 more source

Linking Nutritional, Sensory, and Functional Quality in Plant‐Based Proteins Through Structural Modification and Computational Insights

open access: yesSustainable Food Proteins, Volume 4, Issue 1, March 2026.
The lacking essential amino acids, low digestibility, bioavailability, bitterness, and presence of anti‐nutritional factors that limit the consumption of plant proteins and their use in food formulations are discussed comprehensively. The findings of recent studies on novel technologies and computer‐based applications used to cope with these challenges
Humeyra Cavdar Dincturk   +3 more
wiley   +1 more source

A Holistic Characterization of Soy Protein Isolates From Different Breeding Lines

open access: yesSustainable Food Proteins, Volume 4, Issue 1, March 2026.
A roadmap illustrating how variability among soybean genotypes translates into structural and compositional differences that govern functionality, off‐flavor development, and protein quality. ABSTRACT Soy protein remains the leading plant protein in the growing alternative protein market.
Samira Feyzi, Baraem P. Ismail
wiley   +1 more source

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