Results 41 to 50 of about 140,818 (295)

RETRACTED: QbD-based rivastigmine tartrate-loaded solid lipid nanoparticles for enhanced intranasal delivery to the brain for Alzheimer's therapeutics

Frontiers in Aging Neuroscience, 2022
Alzheimer's disease (AD) is a neurodegenerative disease that affects a wide range of populations and is the primary cause of death in various countries.
Deepshi Arora, Deepshi Arora, Shailendra Bhatt, Manish Kumar, Ravinder Verma, Yugam Taneja, Nikita Kaushal, Abhishek Tiwari, Varsha Tiwari, Athanasios Alexiou, Athanasios Alexiou, Sarah Albogami, Saqer S. Alotaibi, Vineet Mittal, Rajeev K. Singla, Rajeev K. Singla, Deepak Kaushik, Gaber El-Saber Batiha   +17 more
doaj   +1 more source

Evaluation of intranasal delivery route of drug administration for brain targeting.

Brain Research Bulletin, 2018
The acute or chronic drug treatments for different neurodegenerative and psychiatric disorders are challenging from several aspects. The low bioavailability and limited brain exposure of oral drugs, the rapid metabolism, elimination, the unwanted side ...
F. Erdő, L. Bors, Dániel Farkas, Ágnes Bajza, S. Gizurarson   +4 more
semanticscholar   +1 more source

A single intranasal or intramuscular immunization with chimpanzee adenovirus-vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters

Cell Reports, 2021
The development of an effective vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), is a global priority.
T. Bricker, T. Darling, Ahmed O. Hassan, Houda H. Harastani, A. Soung, Xiaoping Jiang, Ya-Nan Dai, Haiyan Zhao, L. Adams, M. Holtzman, Adam Leitman Bailey, J. Case, D. Fremont, R. Klein, M. Diamond, A. Boon   +15 more
semanticscholar   +1 more source

Innovative Aqueous Nanoemulsion Prepared by Phase Inversion Emulsification with Exceptional Homogeneity

Pharmaceutics, 2023
Formulating low-solubility or low-permeability drugs is a challenge, particularly with the low administration volumes required in intranasal drug delivery.
Patrícia C. Pires, Mariana Fernandes, Francisca Nina, Francisco Gama, Maria F. Gomes, Lina E. Rodrigues, Sara Meirinho, Samuel Silvestre, Gilberto Alves, Adriana O. Santos   +9 more
doaj   +1 more source

Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research

Molecular Psychiatry, 2020
Reports on the modulatory role of the neuropeptide oxytocin on social cognition and behavior have steadily increased over the last two decades, stimulating considerable interest in its psychiatric application.
D. Quintana, A. Lischke, Sally A. Grace, D. Scheele, Yina Ma, B. Becker   +5 more
semanticscholar   +1 more source

Formulation of Intranasal Mucoadhesive Thermotriggered In Situ Gel Containing Mirtazapine as an Antidepressant Drug

Gels, 2023
The purpose of the present work was to develop nanoemulsion-based formulations of mirtazapine for intranasal delivery using a spray actuator to target the brain for treating depression.
Mohammed Ghazwani, Rajalakshimi Vasudevan, Geetha Kandasamy, Naredla. Manusri, Praveen Devanandan, Ranadheer Chowdary Puvvada, Vinoth Prabhu Veeramani, Premalatha Paulsamy, Krishnaraju Venkatesan, Kumarappan Chidmabaram, Rajeshri Dhurke   +10 more
doaj   +1 more source

Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge

Vaccines, 2021
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for effective prophylactic vaccination to prevent the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
R. King, A. Silva-Sánchez, Jessica N. Peel, David Botta, A. Dickson, Amelia K. Pinto, S. Meza-Perez, S. Allie, Michael D. Schultz, Mingyong Liu, J. Bradley, S. Qiu, Guang Yang, Fen Zhou, Esther Zumaquero, Thomas S. Simpler, B. Mousseau, J. Killian, B. Dean, Q. Shang, J. Tipper, Christopher A Risley, K. Harrod, Tsungwei Feng, Y. Lee, B. Shiberu, Vyjayanthi Krishnan, I. Peguillet, Jianfeng Zhang, T. Green, T. Randall, J. Suschak, B. Georges, J. Brien, F. Lund, M. Roberts   +35 more
semanticscholar   +1 more source

An Elucidation of Contemporary Brain Targeting Tactics Employed in the Treatment of Neurodegenerative Diseases

Archives of Pharmaceutical Sciences Ain Shams University, 2023
Neurodegenerative diseases (NDDs), a global growing concern, are posing significant social and economic challenges, making the efficient delivery of medications to the brain a pressing demand.
Authman M. Alsamarrai, Ghada M. El Zaafarany, Amany O. Kamel   +2 more
doaj   +1 more source

A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques

bioRxiv, 2021
The deployment of a vaccine that limits transmission and disease likely will be required to end the Coronavirus Disease 2019 (COVID-19) pandemic. We recently described the protective activity of an intranasally-administered chimpanzee adenovirus-vectored
Ahmed O. Hassan, F. Feldmann, Haiyan Zhao, D. Curiel, A. Okumura, Tsing-Lee Tang-Huau, J. Case, Kimberly Meade-White, Julie A. Callison, J. Lovaglio, P. Hanley, D. Scott, D. Fremont, H. Feldmann, M. Diamond   +14 more
semanticscholar   +1 more source

An Improved Tobacco Mosaic Virus (TMV)-Conjugated Multiantigen Subunit Vaccine Against Respiratory Tularemia

Frontiers in Microbiology, 2018
Francisella tularensis, the causative agent of the fatal human disease known as tularemia is classified as a Category A Select Agent by the Centers for Disease Control.
Ahd A. Mansour, Sukalyani Banik, Ragavan V. Suresh, Hardeep Kaur, Meenakshi Malik, Alison A. McCormick, Chandra S. Bakshi   +6 more
doaj   +1 more source