Results 111 to 120 of about 65,548 (298)

Intranasal administration of allergen increases specific IgE whereas intranasal omalizumab does not increase serum IgE levels : a pilot study [PDF]

, 2017
Background: Administration of the therapeutic anti-IgE antibody omalizumab to patients induces strong increases in IgE antibody levels. Objective: To investigate the effect of intranasal administration of major birch pollen allergen Bet v 1, omalizumab ...
Valent, P., Eckl-Dorna, J., I. Mittermann, Gevaert, Philippe, P. Zieglmayer, Gattinger, P., Campana, R., Valenta, R, P. Gevaert, C. Lupinek, K. Blatt, R. Valenta, P. Valent, J. Gamper, Lupinek, C., Perkmann, T., Gamper, J., Mittermann, I, Gamper, J, Niederberger, V, Fröschl, R., I. Steiner, R. Selb, Marth, K., P. Gattinger, R. Kiss, Zieglmayer, P, K. Marth, Blatt, K, Mittermann, I., A. Mayer, Valenta, R., Gangl, K., Gangl, K, Mayer, A., Niederberger, V., Valent, P, Zieglmayer, P., Gattinger, P, Kiss, R., Selb, R., V. Niederberger, Steiner, I., Lupinek, C, Blatt, K., Perkmann, T, Kiss, R, Gevaert, P., Campana, R, Selb, R, Eckl-Dorna, J, Mayer, A, R. Fröschl, Steiner, I, Marth, K, K. Gangl, T. Perkmann, Fröschl, R, J. Eckl-Dorna, R. Campana   +59 more
core   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Cardiac Safety of Intranasal Chlorpheniramine: An Exposure-Based Risk Assessment

Pharmaceuticals
Background: H1-antihistamines are widely used for allergic and upper respiratory conditions; however, several agents included in this class have been associated with cardiac electrophysiological adverse effects, including QT interval prolongation and ...
César Alas-Pineda, Dennis J. Pavón-Varela, Kristhel Gaitán-Zambrano, Gustavo Ferrer   +3 more
doaj   +1 more source

Efficacy of intranasal administration of artesunate in experimental cerebral malaria

, 2014
International audienceBackground: Improving management of patients suffering from cerebral malaria is needed to reduce the devastating mortality and morbidity of the disease in endemic areas.
Gagnieu, Marie-Claude, Bienvenu, Anne-Lise, Bonnot, Guillaume, Picot, Stéphane, Anne-Lise Bienvenu, Anthony Fourier, Lavoignat, Adeline, Coralie Bringer, Anne Marijon, Marie-Claude Gagnieu, Stéphane Picot, Adeline Lavoignat, Fourier, Anthony, Marijon, Anne, Guillaume Bonnot, Bringer, Coralie   +15 more
core   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Elevated salivary levels of oxytocin persist more than seven hours after intranasal administration

Frontiers in Neuroscience, 2012
We addressed the question how long salivary oxytocin levels remain elevated after intranasal administration, and whether it makes a difference when 16 IU or 24 IU of oxytocin administration is used.
Marinus H. Van IJzendoorn, Ritu eBhandari, Rixt evan der Veen, Karen eGrewen, Marian J. Bakermans-Kranenburg   +4 more
doaj   +1 more source

Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice

, 2017
Molecular mechanisms underlying learning and memory remain imprecisely understood, and restorative interventions are lacking. We report that intranasal administration of siRNAs can be used to identify targets important in cognitive processes and to ...
Marco Magistri, Yuyan Cheng, Eleonore Beurel, Cheng, Yuyan, Dmitry Velmeshev, Ana Martinez, Pardo, Marta, Richard S. Jope, Mohammad A. Faghihi, Faghihi, Mohammad A, Eldar-Finkelman, Hagit, Magistri, Marco, Hagit Eldar-Finkelman, Martinez, Ana, Beurel, Eleonore, Jope, Richard S, Velmeshev, Dmitry, Marta Pardo   +17 more
core   +2 more sources

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source