Results 91 to 100 of about 1,950,206 (296)

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

The effects of intranasal oxytocin administration on resting state electroencephalography frontal asymmetry [PDF]

, 2015
Research suggests that the nonapeptide oxytocin plays an important role in social functioning, and that the intranasal administration of exogenous oxytocin promotes prosocial behaviours.
Orlando, Mark Anthony
core   +1 more source

Intranasal Administration of the Combination of Dextro-Ketamine and Dexmedetomidine for Treatment of Diabetic Neuropathic Pain in Rats. [PDF]

J Pain Res
Susumu Zapata Sudo,1,* Tadeu Lima Montagnoli,2,* Bruno Eduardo Dematté,3 Aimeé Diogenes Santos,2 Margarete Manhães Trachez,4 Fernanda Gubert,5 Rosalia Mendez-Otero,6 Gisele Zapata-Sudo1– 5 1Programa de Pós-Graduação em Medicina (Cirurgia Geral ...
Sudo SZ, Montagnoli TL, Dematté BE, Santos AD, Trachez MM, Gubert F, Mendez-Otero R, Zapata-Sudo G.   +7 more
europepmc   +2 more sources

Perspectives on intranasal administration of corticosteroids

, 2023
Intranasal administration of corticosteroids: patients, administration techniques and instructionsIntranasal corticosteroids (INCs) are used in allergic rhinitis and suppress allergic inflammation in the nasal mucosa. Adequate administration of INCs has received limited attention in clinical practice and scientific literature, whilst research about ...
openaire   +2 more sources

Efficacy of intranasal administration of artesunate in experimental cerebral malaria [PDF]

, 2014
International audienceBackground: Improving management of patients suffering from cerebral malaria is needed to reduce the devastating mortality and morbidity of the disease in endemic areas.
Gagnieu, Marie-Claude, Bienvenu, Anne-Lise, Bonnot, Guillaume, Picot, Stéphane, Anne-Lise Bienvenu, Anthony Fourier, Lavoignat, Adeline, Coralie Bringer, Anne Marijon, Marie-Claude Gagnieu, Stéphane Picot, Adeline Lavoignat, Fourier, Anthony, Marijon, Anne, Guillaume Bonnot, Bringer, Coralie   +15 more
core   +1 more source

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

Animal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen, Xiangfang Tang, Yimin Zhuang, Shengjun Zhao, Ying Ren, Xiaokang Lv   +5 more
wiley   +1 more source

Intranasal Delivery of Brain‐Derived Neurotrophic Factor (BDNF)‐Loaded Small Extracellular Vesicles for Treating Acute Spinal Cord Injury in Rats and Monkeys

Journal of Extracellular Vesicles
Besides surgical decompression, neuroprotection and neuroinflammation reduction are critical for acute spinal cord injury (SCI). In this study, we prepared small extracellular vesicles (sEVs) from immortalised mesenchymal stem cells overexpressing brain ...
Zhonghai Huang, Jing Li, Jin Wo, Cheng‐Lin Li, Zi‐Cong Wu, Xiao‐Hui Deng, Yaying Liang, Fuxiang Li, Boli Chen, Bin Jia, Lu Wang, Ying Wang, Guodong Sun, Zhizhong Li, Hui Zhu, James D Guest, Kwok‐Fai So, Qing‐Ling Fu, Libing Zhou   +18 more
doaj   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Cardiac Safety of Intranasal Chlorpheniramine: An Exposure-Based Risk Assessment

Pharmaceuticals
Background: H1-antihistamines are widely used for allergic and upper respiratory conditions; however, several agents included in this class have been associated with cardiac electrophysiological adverse effects, including QT interval prolongation and ...
César Alas-Pineda, Dennis J. Pavón-Varela, Kristhel Gaitán-Zambrano, Gustavo Ferrer   +3 more
doaj   +1 more source

The dantrolene concentrations in the brain over time after intranasal vs oral administration.

, 2020
There were no significant differences in the dantrolene brain/plasma ratios between intranasal and oral administration. The oral brain/plasma ratio fell to zero while the intranasal dantrolene brain/plasma ratio was sustained through 180 min.
Yun Shi (172065), Huafeng Wei (333273), Shuchun Yu (782080), Yan Wang (15435), Qingcheng Meng (8561451), Ge Liang (578601), Jintao Wang (8051), Maryellen F. Eckenhoff (8561454)   +7 more
core   +1 more source