Results 141 to 150 of about 1,950,206 (296)

Longitudinal Cognitive Function in Progressive Supranuclear Palsy—A Review of the Evidence for Progression

Movement Disorders Clinical Practice, EarlyView.
Abstract Progressive supranuclear palsy is a rare and rapidly progressive neurodegenerative syndrome. Clinical manifestations are heterogeneous and include Parkinsonism, postural instability, oculomotor dysfunction and cognitive impairment, with 80% of patients progressing to dementia within 3 years. Cognitive impairment is consistently associated with
Timothy P. Siejka, Kelly L. Bertram, Helmut Butzkueven, David Darby, Amy Brodtmann   +4 more
wiley   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

Chronic High‐Dose Ketamine Fails to Induce a Cystitis‐Like Phenotype in Mice Despite High Urinary Metabolite Levels

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims Ketamine‑induced cystitis (KIC) is a severe complication of chronic ketamine misuse, yet the underlying mechanisms remain poorly understood. Established rodent models have demonstrated variable changes in voiding behavior and bladder histology, without exploring the sensory mechanisms underlying altered voiding and pain at all. This study
Jill Dewez, Ashlee Caldwell, Laura Schillebeeckx, Margot De Vis, Sylvia João Poseiro Coutinho Pinto, Evy Van Den Broek, Véronique Hendrickx, Katrien Luyten, Marcella Baldewijns, Jan Tytgat, Thomas Voets, Wouter Everaerts   +11 more
wiley   +1 more source

Intranasal administration of Simvastatin for Neuroprotection

, 2022
O acidente vascular cerebral isquémico é uma das doenças crónicas com maior impacto mundial e uma das principais causas de morte e incapacidade. Devido ao escasso número de opções terapêuticas e algumas das suas limitações, é necessário encontrar alternativas para prevenir e tratar casos de acidente vascular isquémico.
openaire   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Efficacy of Exhalation Delivery System With Fluticasone in Chronic Rhinosinusitis With Versus Without Polyps

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To evaluate whether treatment responses to the exhalation delivery system with fluticasone (EDS‐FLU; XHANCE®) differ between patients with CRS with nasal polyps (CRSwNP) and patients without nasal polyps (CRSsNP). Study Design Post hoc analysis of the ReOpen clinical trials conducted between November 2018 and November 2021 for a 24 ...
Rodney J. Schlosser, Nithin D. Adappa, Rakesh K. Chandra, Greg E. Davis, Mahboobeh Mahdavinia, John Messina, Zara M. Patel, Anju T. Peters, Raj Sindwani, Zachary M. Soler, Andrew A. White, Sarah K. Wise, James N. Palmer   +12 more
wiley   +1 more source

Cryotherapy as Treatment for Chronic Rhinitis: Long‐Term Results of a Prospective, Multicenter Registry

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective The purpose of this registry was to capture observational data on a large and diverse cohort treated with the ClariFix Cryotherapy device for chronic rhinitis. Study Design Prospective, multicenter, nonrandomized, observational registry. Setting Twenty‐two tertiary care and private otolaryngology practices. Methods ClariFix treatment
Amber U. Luong, Neelesh H. Mehendale, Emily Szabo, Farhad Sigari, Anthony G. Del Signore, David M. Yen   +5 more
wiley   +1 more source

Early Growth Response 1‐Associated Epithelial Autophagy‐Related Changes in Allergic Airway Inflammation

Pediatric Discovery, EarlyView.
House dust mite (HDM) exposure induces early growth response 1 (EGR1) expression in airway epithelial cells and is accompanied by autophagy‐associated alterations, including increased LC3B‐II and Vps34 levels and decreased p62 abundance. Manipulation of EGR1 expression modulates these autophagy‐related changes, whereas pharmacological inhibition of ...
Xinyang Wang, Jie Ren, Yan Zhao, Zhengxiu Luo   +3 more
wiley   +1 more source

Nose-to-Eye Delivery: The Potential of Intranasal Administration in Ophthalmology. [PDF]

J Clin Med
Adezio ML, Iannetta D, Manni G, Visioli G, Roberti G, Alisi L.   +5 more
europepmc   +1 more source