Results 241 to 250 of about 2,191,985 (278)

Concentrated Midazolam for Intranasal Administration

Pediatric Emergency Care, 2011
N ...
Calligaris, Lorenzo, Davide, Zanon, Alessandra, Maestro, DE BORTOLI, ROMINA, Chiaretti, Antonio, Barbi, Egidio   +5 more
openaire   +2 more sources

Brain distribution of ribavirin after intranasal administration

Antiviral Research, 2011
Ribavirin has proved to be effective in vitro against several RNA viruses responsible for encephalitis in humans and animals. However, the in vivo efficacy towards the cerebral viral load seems to be limited by the blood-brain barrier. Since the nose-to-brain pathway has been indicated for delivering drugs to the brain, we investigated here the ...
Colombo G., LORENZINI, LUCA, ZIRONI, ELISA, GALLIGIONI, VIOLA, Sonvico F., Balducci A.G., PAGLIUCA, GIAMPIERO, GIULIANI, ALESSANDRO, CALZA', LAURA, SCAGLIARINI, ALESSANDRA   +9 more
openaire   +4 more sources

Salivary vasopressin increases following intranasal oxytocin administration

Peptides, 2013
Extant research has documented the effects of intranasal administration of oxytocin (OT), and to a lesser degree Arginine Vasopressin (AVP) - two structurally-related neuropeptides - on brain and behaviour, yet the effects of exogenous manipulation of one on circulating levels of the other remain unknown.
Omri, Weisman, Inna, Schneiderman, Orna, Zagoory-Sharon, Ruth, Feldman   +3 more
openaire   +2 more sources

Intranasal administration nanosystems for brain-targeted drug delivery

Nano Reseach, 2023
Yue Jiang, Xueting Pan, Tao Yu, Hai Wang
semanticscholar   +1 more source

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery.

Journal of Visualized Experiments, 2018
Intranasal administration has been reported to be a potential pathway for nose-to-brain delivery of therapeutic agents that circumvents the blood-brain barrier.
T. Kanazawa, Mitsuyoshi Fukuda, N. Suzuki, Toyofumi Suzuki   +3 more
semanticscholar   +1 more source

Pharmacokinetics and Pharmacodynamics of Midazolam After Intranasal Administration

The Journal of Clinical Pharmacology, 1997
This study aimed to characterize the pharmacokinetics and pharmacodynamics of midazolam after intranasal administration to healthy volunteers. Eight participants were given 0.25 mg/kg intranasally and 2 mg intravenously in a randomized, crossover fashion.
A H, Burstein, R, Modica, M, Hatton, A, Forrest, F M, Gengo   +4 more
openaire   +2 more sources

Intranasal Administration of IL-27 Ameliorates Nasal Allergic Responses and Symptoms

International Archives of Allergy and Immunology, 2018
Background: Interleukin 27 (IL-27) is an initiator of the Th1 response and inhibits inflammatory responses. In a mouse model of asthma, administration of IL-27 reduced eosinophil numbers in bronchoalveolar lavage fluid and airway hyperresponsiveness ...
Motohiko Suzuki, M. Yokota, S. Ozaki, Tamami Matsumoto   +3 more
semanticscholar   +1 more source

Hydromorphone Transfer into Breast Milk After Intranasal Administration

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2003
Study Objectives . To determine the distribution of hydromorphone into breast milk and the potential exposure of the suckling infant, and whether the distribution of hydromorphone into milk can be predicted accurately by a passive diffusion model. Design
Jeffrey E, Edwards, Anita C, Rudy, Daniel P, Wermeling, Nirmala, Desai, Patrick J, McNamara   +4 more
openaire   +2 more sources

Accidental intranasal administration of phenol.

Veterinary and human toxicology, 1999
A 79-y-old man developed erythema and superficial sloughing of the turbinate following accidental intranasal administration of 89.2% phenol solution. Previous documented reports of phenol exposure include exposures via dermal and oral routes, but no reports of nasal phenol administration were found.
L F, Durback-Morris, E J, Scharman
openaire   +1 more source

Intranasal administration of desmopressin acetate (DDAVP) to hemophiliacs

Thrombosis Research, 1980
Abstract The intravenous infusion of desmopressin acetate (DDAVP), a synthetic vasopressin analogue, has been shown to cause a sustained increase in all Factor VIII related properties (VIII-C, VIIIR-Ag, VIIIR-WF) in patients with mild to moderate hemophilia and von Willebrand's disease. This study examines the effect of high doses of intranasal DDAVP
D L, Dewald, B, Briggs, R E, Smith
openaire   +2 more sources