Results 61 to 70 of about 64,289 (299)

PIPAC-OV3: A multicenter, open-label, randomized, two-arm phase III trial of the effect on progression-free survival of cisplatin and doxorubicin as Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) vs. chemotherapy alone in patients with platinum-resistant recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer [PDF]

, 2018
BACKGROUND: Recurrent, platin-resistant ovarian cancer (rPROC) has a poor survival. Even with the AURELIA trial, which is the best available treatment today, progression-free survival (PFS) is still only 6.7 months from the start of the second-line ...
Scambia, Giovanni
core   +1 more source

Advances in Treatment Models of Advanced Gastric Cancer

Technology in Cancer Research & Treatment, 2022
The prognosis of advanced gastric cancer (AGC) is extremely poor, and the therapeutic effect of traditional palliative chemotherapy is far from satisfactory.
Tao Li, Yufang He, Qinglei Zhong, Jiang Yu, Xinhua Chen   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Intraperitoneal follicular dendritic cell sarcoma: Role of chemotherapy and bone marrow allotransplantation in locally advanced disease? [PDF]

, 2015
We describe a case of a 44 year-old woman diagnosed with follicular dendritic cell sarcoma (FDCS). FDCS is a very rare disease affecting the dendritic antigen presenting cells and is often misdiagnosed.
De Saint Aubain, Nicolas, El Nakadi, I., El Nakadi, Issam, I. El Nakadi, Liberale, Gabriel, N. De Saint Aubain, Keriakos, Kiril, G. Liberale, De Saint Aubain, N., K. Keriakos, M. A. Azerad, Liberale, G., Azerad, Marie-Agnès, Keriakos, K.   +13 more
core   +1 more source

Effect of Cilastatin on Cisplatin-Induced Nephrotoxicity in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy [PDF]

, 2021
Cisplatin is one of the most widely used chemotherapeutic agents in oncology, although its nephrotoxicity limits application and dosage. We present the results of a clinical study on prophylaxis of cisplatin-induced nephrotoxicity in patients with ...
Vasquez-Jimenez, Wenceslao, Canal Alonso, María Iluminada, Canal-Alonso, María Iluminada, Pilar Cabrerizo-Torrente, Ginel-Feito, María Dolores, María Dolores Ginel-Feito, Palencia-García, Natividad, Lozano-Lominchar, Pablo, González Nicolás González, María Ángeles, Lázaro Fernández, Alberto, Mercedes Power, Consuelo Jiménez, Palencia García, Natividad, Matilde Zaballos, Zaballos, Matilde, Natividad Palencia-García, González-Bayón, Luis, Vasquez Jimenez, Wenceslao, Gago Quiroga, Susana, María Ángeles González-Nicolás, Alberto Lázaro, María Iluminada Canal-Alonso, Jiménez, Consuelo, Susana Gago-Quiroga, Pablo Lozano-Lominchar, González Bayón, Luis, Zaballos García, Matilde, Wenceslao Vasquez-Jimenez, Lázaro, Alberto, Gago-Quiroga, Susana, Luis González-Bayón, Ginel Feito, María Dolores, Power, Mercedes, González-Nicolás, María Ángeles, Cabrerizo-Torrente, Pilar, Cabrerizo Torrente, Pilar, Lozano Lominchar, Pablo   +36 more
core   +2 more sources

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Primary ovarian high-grade endometrial stromal sarcoma: a case report

Journal of Medical Case Reports, 2021
Background Primary ovarian high-grade endometrial stromal sarcoma is a very rare disease. Even though it has poor prognosis, the gold standard treatment has not been established owing to its rarity.
Ji Sun Lee, Dayong Lee, Jisun Lee, Man-Hoon Han, Dae Gy Hong, Hyun Jung Lee   +5 more
doaj   +1 more source

Assessment of Hyperthermic Intraperitoneal Chemotherapy to Eradicate Intraperitoneal Free Cancer Cells

Translational Oncology, 2016
OBJECTIVE: To assess the effect of hyperthermic intraperitoneal chemotherapy (HIPEC) to eradicate intraperitoneal free cancer cells and to explore the feasibility of cytological cure for peritoneal carcinomatosis (PC).
Zhonghe Ji, Jianhua Sun, Haitao Wu, Qian Zhang, Kaiwen Peng, Yan Li   +5 more
doaj   +1 more source

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

Advanced Healthcare Materials, EarlyView.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan, Po‐Han Chao, XuXin Sun, Jun Han, Sarah MacPherson, Lucas J. Andrew, Noah Y. Brittain, Tien Do, Marcel B. Bally, Julian J. Lum, Shyh‐Dar Li   +10 more
wiley   +1 more source