Results 1 to 10 of about 913 (113)

Safety and efficacy of cisplatin and nab-paclitaxel pressurised intraperitoneal aerosol chemotherapy (PIPAC) in patients with peritoneal carcinomatosis: Nab-PIPAC phase 1b study [PDF]

EBioMedicine
Summary: Background: Platinum and taxanes are backbone chemotherapy in multiple solid tumours. We aimed to investigate the safety, tolerability, and pharmacokinetics of nab-paclitaxel and cisplatin administered by pressurised intraperitoneal aerosol ...
Manuela Undurraga, Noemie Lang, Thibaud Koessler, Antonella Diciolla, Mariagrazia Di Marco, Nicolas Mach, Catherine Raimond, Vassilis Genoud, Valentine Du Bois, Jean-Christophe Tille, Aurelie Bornand, Jonathan S. Moore, Marc Weiner, Laure Smekens, José L. Sandoval, Julie Terzic, Yann Christinat, Jennifer Veillard, Petros Tsantoulis, Paul Thoueille, Thomas Mercier, Stefan Monig, Patrick Petignat, Christian Toso, Laurent Decosterd, Martin Hübner, Intidhar Labidi-Galy, Frederic Ris   +27 more
doaj   +2 more sources

Pressurized intraperitoneal aerosol chemotherapy enhances cisplatin efficacy in colorectal cancer organoids [PDF]

Scientific Reports
Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is an emerging method that delivers chemotherapeutic agents as aerosols directly into the peritoneal cavity to overcome poor tissue penetration.
Soon-Chan Kim, Shin Ae Lee, Min Jung Kim, Young-Kyoung Shin, Hee Seung Kim, Seung-Yong Jeong, Ja-Lok Ku, Ji Won Park   +7 more
doaj   +2 more sources

Adjuvant pressurized intraperitoneal aerosol chemotherapy (PIPAC) in suboptimally cytoreduced advanced ovarian cancer: a randomized phase II trial (PIPAC-OVA) [PDF]

BMC Cancer
Purpose Patients with advanced epithelial ovarian cancer (EOC) who undergo suboptimal primary cytoreductive surgery (PCS) have poor outcomes with standard platinum–taxane chemotherapy.
Alexey S. Dzasokhov, Vladimir M. Khomyakov, Artur V. Turiev, Vladimir L. Astashov, Andrey A. Kostin, Sergey O. Gunyakov, Marina A. Andreeva   +6 more
doaj   +2 more sources

PICCOS: study protocol for pressurised intraperitoneal aerosolised chemotherapy (PIPAC) in the management of cancers of the colon, ovary and stomach: a randomised controlled, phase II trial of efficacy in peritoneal metastases [PDF]

Pleura and Peritoneum
Peritoneal metastases (PM) represent a significant unmet need requiring urgent development of treatment options to improve patient prognosis and quality of life (QoL). A novel anti-cancer technology is Pressurised IntraPeritoneal Aerosolised Chemotherapy
Jones Sadie E.F., Brogden Elena, Murphy Jamie, Peters Christopher J., Frost Jonathan, Adams Richard, Gwynne Sarah, Hudson Emma, Perry Kitrick, Casbard Angela, Hamilton Rebecca, Nixon Lisette, Markham Philip, Mohamed Huda, Brown Gina, Blazeby Jane, Fitzsimmons Deborah, Ajakaiye Anuoluwa, Batten Leona M., Edgar Maureen, Case Amy, Kyle Peter, Tate Sophie, Arndell Karen, Elliott Daisy, Macefield Rhiannon, Chuter David, Hall Harry, Garfitt Joy, Torkington Jared   +29 more
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Treatment of colorectal peritoneal metastases with oxaliplatin induces biomarkers predicting response to immune checkpoint blockade [PDF]

Translational Oncology
Background: Colorectal cancer (CRC) patients with inoperable peritoneal metastases (PM) have a dismal prognosis with limited treatment options. Local treatment of CRC-PM with oxaliplatin is commonly applied, but biomarkers steering patient selection, or ...
Alexander Constantinides, Nico Lansu, Peter Mosen, Paulien Rauwerdink, Esther Strating, Franziska Völlmy, Maaike Nederend, Jeanette H.W. Leusen, Koen Rovers, Emma Wassenaar, Robin Lurvink, Maarten Altelaar, Simon Nienhuijs, Rene Wiezer, Inne H.M. Borel Rinkes, Djamila Boerma, Geert J.P.L. Kops, Ignace de Hingh, Onno Kranenburg   +18 more
doaj   +2 more sources

Assessing data completeness in the international society for the study of pleura and peritoneum (ISSPP) PIPAC database: a multicenter evaluation from 2020–2024 [PDF]

Pleura and Peritoneum
In 2020, Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) reached stage 2b of the IDEAL framework and a prospective international PIPAC database was launched in June 2020 by the International Society for the Study of the Pleura and Peritoneum ...
Jørgensen Magnus Skov, Hansen Pernille Shjødt, Fristrup Claus Wilki, Hübner Martin, So Jimmy, Ezanno Anne-Cecile, Hewett Peter, Ruiz-Marin Miguel, Rezniczek Günther, Düzgün Özgül, Pocard Marc, Casella Francesco, Lay Laura, Aral Marisa, Jäger Tarkan, Laminger Felix, Glehen Oliver, Goutard Claire-Angéline, Villeneuve Laurent, Di Giorgio Andrea, Mortensen Michael Bau   +20 more
doaj   +2 more sources

Real-world data on Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)-directed therapy in patients with peritoneal metastases; Third annual report from the ISSPP PIPAC database [PDF]

Pleura and Peritoneum
In 2020, the International Society for the Study of the Pleura and Peritoneum (ISSPP) launched a database monitoring real-world data on Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)-directed therapy in patients with peritoneal metastases (PM).
Jørgensen Magnus Skov, Hansen Pernille Schjødt, Fristrup Claus W., Hübner Martin, So Jimmy, Ezanno Anne-Cecile, Hewett Peter, Ruiz-Marin Miguel, Rezniczek Günther A., Düzgün Özgül, Pocard Marc, Casella Francesco, Lay Laura, Aral Marisa, Jäger Tarkan, Laminger Felix, Glehen Oliver, Goutard Claire-Angéline, Villeneuve Laurent, Di Giorgio Andrea, Mortensen Michael Bau   +20 more
doaj   +2 more sources

What is long-term survival in patients with peritoneal metastasis from gastric, pancreatic, or colorectal cancer? A study of patients treated with systemic chemotherapy and pressurized intraperitoneal aerosol chemotherapy (PIPAC)

Pleura and Peritoneum, 2023
A definition of long-term survival (LTS) in patients with peritoneal metastasis (PM) from gastric cancer (GC), pancreatic cancer (PC) or colorectal cancer (CRC) treated with systemic chemotherapy and pressurized intraperitoneal aerosol chemotherapy ...
Kryh-Jensen Charlotte G., Fristrup Claus W., Ainsworth Alan P., Detlefsen Sönke, Mortensen Michael B., Pfeiffer Per, Tarpgaard Line S., Graversen Martin   +7 more
doaj   +1 more source

Reasons for stopping Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC): A retrospective study to improve future patient selection.

PLoS ONE, 2023
To improve the prognosis and maintain quality of life in patients with peritoneal metastasis (PM), a novel treatment has been introduced-pressurized intraperitoneal aerosol chemotherapy (PIPAC).
Anne-Cécile Ezanno, Brice Malgras, Pierre-Louis Conan, Adeline Aime, Jade Fawaz, Hugo Picchi, Solène Doat, Marc Pocard   +7 more
doaj   +1 more source

Importance of biopsy site selection for peritoneal regression grading score (PRGS) in peritoneal metastasis treated with repeated pressurized intraperitoneal aerosol chemotherapy (PIPAC)

Pleura and Peritoneum, 2022
The four-tiered peritoneal regression grading score (PRGS) is used for histological response evaluation in patients with peritoneal metastasis (PM) treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC).
Fallah Mojib, Detlefsen Sönke, Ainsworth Alan P., Fristrup Claus W., Mortensen Michael B., Pfeiffer Per, Tarpgaard Line S., Graversen Martin   +7 more
doaj   +1 more source