Results 61 to 70 of about 1,759 (164)

Contrast‐Enhanced 3T Vessel Wall Imaging for Symptomatic Intracranial Atherosclerotic Stenosis: Value of Pituitary Stalk Reference

Clinical Neuroimaging, Volume 3, Issue 1, 2026.
ABSTRACT Background Three‐dimensional vessel wall imaging (VWI) using 3T MRI enables detailed assessment of intracranial atherosclerotic stenosis (ICAS), but the optimal reference tissue and its clinical utility remain unclear. This study aimed to identify the most suitable reference tissue for contrast‐enhanced (CE) VWI and to clarify imaging ...
Kensaku Senda, Manabu Shirakawa, Kazutaka Uchida, Fumihiro Sakakibara, Kiyofumi Yamada, Shinichi Yoshimura   +5 more
wiley   +1 more source

Multimodal Radiomics Model Combining HR‐VWI and Clinical Features for Identifying Symptomatic Basilar Atherosclerotic Plaques

BioMed Research International, Volume 2026, Issue 1, 2026.
Objective This study is aimed at exploring the value of a high‐resolution vessel wall imaging (HR‐VWI)–based radiomics approach for identifying symptomatic basilar atherosclerotic plaques. Materials and Methods This retrospective study included 154 patients, hospitalized at Shanxi Cardiovascular Hospital for cerebrovascular disease, who had basilar ...
Juan Bai, Caixian Yang, Ning Li, Xiaoyong Hao, Lina Zhu, Jingxi Yan, Jiang Wu, Mengzhu Wang, Poorani Gurumallesh Prabu   +8 more
wiley   +1 more source

Plaque angiogenesis and intraplaque hemorrhage in atherosclerosis.

, 2017
Acute cardiovascular events, due to rupture or erosion of an atherosclerotic plaque, represent the major cause of morbidity and mortality in patients. Growing evidence suggests that plaque neovascularization is an important contributor to plaque growth ...
Paul H.A. Quax, Fabiana Baganha, Margreet R. de Vries, Vries, M.R. de, Laura Parma, Quax, P.H.A., Margreet R de Vries, Parma, L., Paul HA Quax, Baganha, F.   +9 more
core   +1 more source

Data_Sheet_1_Endothelial ADAM10 controls cellular response to oxLDL and its deficiency exacerbates atherosclerosis with intraplaque hemorrhage and neovascularization in mice.pdf

, 2023
IntroductionThe transmembrane protease A Disintegrin And Metalloproteinase 10 (ADAM10) displays a “pattern regulatory function,” by cleaving a range of membrane-bound proteins.
Timo Rademakers (12245494), Linsey J. F. Peters (11056921), Han Jin (1501591), Michael Lehrke (26749), Corinna Lebherz (266490), Andreas Ludwig (92950), Erik A. L. Biessen (9233297), Mat Rousch (134231), Jacob F. Bentzon (8939504), Daniela Yildiz (11851994), Christian Weber (86566), Kosta Theodorou (13883635), Sanne L. Maas (14512121), Marion J. Gijbels (11145291), Yvonne Jansen (781034), Marjo M. P. C. Donners (14512124), Emiel P. C. van der Vorst (11652205)   +16 more
core   +1 more source

Novel treatment from a botanical formulation Si-Miao-Yong-an decoction inhibits vasa vasorum angiogenesis and stabilizes atherosclerosis plaques via the Wnt1/β-catenin signalling pathway

Pharmaceutical Biology, 2023
Context Si-Miao-Yong-An (SMYA) has been widely used for the clinical treatment of atherosclerosis (AS). Yet, its complete mechanism of action is not fully understood.Objective To investigate the mechanism by which SMYA stabilizes AS plaques from the ...
Zhongwen Qi, Zhipeng Yan, Ke Zhu, Yueyao Wang, Yajie Fan, Tingting Li, Junping Zhang   +6 more
doaj   +1 more source

Application Value of Machine Learning Diagnosis Model Based on Multimodal Ultrasound in Carotid Plaque Vulnerability

Journal of Cardiac Surgery, Volume 2026, Issue 1, 2026.
Objective To explore the application value of a machine learning diagnosis model based on multimodal ultrasound in assessing carotid plaque vulnerability. Methods A retrospective study was conducted, selecting 100 patients with carotid plaques admitted to our hospital from January 2022 to August 2023.
Jiaojun Yan, Danlin Wen, Hu Chen, Hang Li, Yunhao Luo, Jin Li, Yuefeng Yang, Lin Zhu, Junxuan He, Qian Diao, Lang Qiao, Jeffrey Goldberger   +11 more
wiley   +1 more source

Low‐Intensity Focused Ultrasound‐Responsive Ferrite‐Encapsulated Nanoparticles for Atherosclerotic Plaque Neovascularization Theranostics

Advanced Science, 2021
Pathological angiogenesis is a crucial factor that causes atherosclerotic plaque rupture. Sinoporphyrin sodium‐mediated sonodynamic therapy (DVDMS‐SDT) induces regression of plaque neovascularization in humans without causing obvious side effects ...
Jianting Yao, Zhuowen Yang, Liandi Huang, Chao Yang, Jianxin Wang, Yang Cao, Lan Hao, Liang Zhang, Jingqi Zhang, Pan Li, Zhigang Wang, Yang Sun, Haitao Ran   +12 more
doaj   +1 more source

Nanozymes for Non‐Neoplastic Diseases: Catalytic Therapy Redefined

Aggregate, Volume 6, Issue 11, November 2025.
Non‐neoplastic diseases pose a significant health burden. Nanozymes, enzyme‐like nanomaterials, offer promising strategies for regulating oxidative stress and inflammation. This review explores their development, structure–function relationships, and therapeutic potential, with a focus on precision medicine through targeted delivery and multimodal ...
Ling Mei, Xikai Wang, Zhuang Hu, Jierui Yan, Xiaobo Wang, Haoran Wang, Ya Hou, Pengfei Zhang, Qihang Ding   +8 more
wiley   +1 more source

SIGNIFICANCE OF INTRAPLAQUE NEOVASCULARIZATION FOR VULNERABILITY: OPTICAL COHERENCE TOMOGRAPHY STUDY

Journal of the American College of Cardiology, 2012
The in vivo significance of intraplaque angiogenesis is not fully understood. The present study was designed to investigate the significance of intraplaque neovascularizaton (NV) in culprit lesions and non-culprit lesions of unstable angina pectoris (UAP) and in lesions of stable angina pectoris (
Tian, JinWei, Hou, Jingbo, Xing, Lei, Jia, Haibo, Zhang, Shaosong, Yu, Bo, Jang, Ik-Kyung   +6 more
openaire   +1 more source

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9): The Multifaceted Biology, Diseases, and Pharmaceutical Interventions

MedComm, Volume 6, Issue 11, November 2025.
Summary of PCSK9 inhibitor mechanisms. PCSK9 inhibitors (PCSK9‐i) primarily lower LDL‐cholesterol (LDL‐C) by blocking PCSK9‐mediated degradation of hepatic LDL receptors (LDLR), enhancing LDL clearance. Beyond LDLR‐dependent effects, PCSK9‐i exert multiple benefits via LDLR‐independent pathways.
Jia Kuang, Lei Hao, Meibiao Zhang, Zhao Yang   +3 more
wiley   +1 more source