Results 61 to 70 of about 24,723 (162)

The HCMV‐encoded miR‐UL36‐3p promotes angiogenesis of endothelial cells by downregulating FOXO3

Animal Models and Experimental Medicine, Volume 9, Issue 5, Page 980-990, May 2026.
This illustration shows the role of hcmv‐miR‐UL36‐3p in endothelial cell angiogenesis. During productive infection, endothelial cells express HCMV‐encoded miRNAs. Viral hcmv‐miR‐UL36‐3p promotes endothelial cell proliferation, migration, and capillary tube formation by directly targeting and downregulating FOXO3. The pro‐angiogenic activity of hcmv‐miR‐
Chen Wang, Mengyu Li, Guosheng Li, Hao Zhang, Cheng Wang, Chen‐Yu Zhang   +5 more
wiley   +1 more source

Neovascularization and Intraplaque Hemorrhage in Atherosclerotic Plaque Destabilization-A Mathematical Model

Molecular & Cellular Biomechanics, 2019
Observational studies have identified angiogenesis from the adventitial vasa vasorum and intraplaque hemorrhage (IPH) as critical factors in atherosclerotic plaque progression and destabilization. Here we propose a mathematical model incorporating intraplaque neo vascularization and hemodynamic calculation for the quantitative evaluation of ...
Guo, Muyi, Cai, Yan, Li, Zhiyong
openaire   +2 more sources

Novel treatment from a botanical formulation Si-Miao-Yong-an decoction inhibits vasa vasorum angiogenesis and stabilizes atherosclerosis plaques via the Wnt1/β-catenin signalling pathway

Pharmaceutical Biology, 2023
Context Si-Miao-Yong-An (SMYA) has been widely used for the clinical treatment of atherosclerosis (AS). Yet, its complete mechanism of action is not fully understood.Objective To investigate the mechanism by which SMYA stabilizes AS plaques from the ...
Zhongwen Qi, Zhipeng Yan, Ke Zhu, Yueyao Wang, Yajie Fan, Tingting Li, Junping Zhang   +6 more
doaj   +1 more source

Cerebral Infarction: Epidemiology, Classification, Mechanisms, Diagnosis, and Management

MedComm, Volume 7, Issue 4, April 2026.
Within minutes after ischemia onset, deprivation of oxygen and glucose leads to rapid ATP depletion, resulting in failure of Na+/K+‐ATPase activity and membrane depolarization. This ionic imbalance promotes uncontrolled synaptic release of glutamate and excessive activation of postsynaptic NMDA and AMPA receptors.
Meibiao Zhang, Jianxun Hou, Jia Kuang, Lei Hao, Zhao Yang   +4 more
wiley   +1 more source

SIGNIFICANCE OF INTRAPLAQUE NEOVASCULARIZATION FOR VULNERABILITY: OPTICAL COHERENCE TOMOGRAPHY STUDY

Journal of the American College of Cardiology, 2012
The in vivo significance of intraplaque angiogenesis is not fully understood. The present study was designed to investigate the significance of intraplaque neovascularizaton (NV) in culprit lesions and non-culprit lesions of unstable angina pectoris (UAP) and in lesions of stable angina pectoris (
Tian, JinWei, Hou, Jingbo, Xing, Lei, Jia, Haibo, Zhang, Shaosong, Yu, Bo, Jang, Ik-Kyung   +6 more
openaire   +1 more source

Low‐Intensity Focused Ultrasound‐Responsive Ferrite‐Encapsulated Nanoparticles for Atherosclerotic Plaque Neovascularization Theranostics

Advanced Science, 2021
Pathological angiogenesis is a crucial factor that causes atherosclerotic plaque rupture. Sinoporphyrin sodium‐mediated sonodynamic therapy (DVDMS‐SDT) induces regression of plaque neovascularization in humans without causing obvious side effects ...
Jianting Yao, Zhuowen Yang, Liandi Huang, Chao Yang, Jianxin Wang, Yang Cao, Lan Hao, Liang Zhang, Jingqi Zhang, Pan Li, Zhigang Wang, Yang Sun, Haitao Ran   +12 more
doaj   +1 more source

High Resolution Magnetic Resonance Vessel Wall Imaging: A Valuable Addition to Stroke Work‐Up

European Journal of Neurology, Volume 33, Issue 3, March 2026.
ABSTRACT Background Intracranial High‐Resolution Vessel Wall (HRVW) MRI is sometimes used alongside standard ischemic stroke (IS) work‐up, yet its clinical and therapeutic interests remain debated. We aimed to assess the intracranial HRVW‐MRI findings in IS patients and their impact on the IS etiologic classification as well as on treatment ...
Grace Adwane, Alexia Tran, Pierre seners, Julien Savatovsky, Michael Obadia   +4 more
wiley   +1 more source

Fluorescein angiography compared to three-dimensional measurements by the retinal thickness analyzer in classic choroidal neovascularization [PDF]

, 2007
Purpose: To compare and correlate imaging of classic subfoveal choroidal neovascularization (CNV) with noninvasive 3-dimensional imaging by the retinal thickness analyzer (RTA) to conventional fluorescein angiography (FA).
Strauss, R. W., Rombold, F., Neubauer, A. S., Kampik, Anselm   +3 more
core   +1 more source

Angiogenesis within atherosclerotic plaques: Mechanical regulation, molecular mechanism and clinical diagnosis

Mechanobiology in Medicine
Atherosclerosis (AS) is a disease characterized by focal cholesterol accumulation and insoluble inflammation in arterial intima, leading to the formation of an atherosclerotic plaque consisting of lipids, cells, and fibrous matrix. The presence of plaque
Hanxiao Chen, Chengxiu Peng, Fei Fang, Yuhao Li, Xiaran Liu, Ying Hu, Guixue Wang, Xiaoheng Liu, Yang Shen   +8 more
doaj   +1 more source

Contrast‐Enhanced 3T Vessel Wall Imaging for Symptomatic Intracranial Atherosclerotic Stenosis: Value of Pituitary Stalk Reference

Clinical Neuroimaging, Volume 3, Issue 1, 2026.
ABSTRACT Background Three‐dimensional vessel wall imaging (VWI) using 3T MRI enables detailed assessment of intracranial atherosclerotic stenosis (ICAS), but the optimal reference tissue and its clinical utility remain unclear. This study aimed to identify the most suitable reference tissue for contrast‐enhanced (CE) VWI and to clarify imaging ...
Kensaku Senda, Manabu Shirakawa, Kazutaka Uchida, Fumihiro Sakakibara, Kiyofumi Yamada, Shinichi Yoshimura   +5 more
wiley   +1 more source