Results 81 to 90 of about 1,759 (164)

An assessment of the vulnerability of carotid plaques: a comparative study between intraplaque neovascularization and plaque echogenicity [PDF]

BMC Medical Imaging, 2013
Abstract Background Carotid plaque echolucency as detected by Color Doppler ultrasonography (CDUS) has been used as a potential marker of plaque vulnerability. However, contrast-enhanced ultrasound (CEUS) has recently been shown to be a valuable method to evaluate the vulnerability and neovascularization within ...
Yangyang Zhou, Yingqi Xing, Yan Li, Yang Bai, Ying Chen, Xiaofeng Sun, Yingqiao Zhu, Jiang Wu   +7 more
openaire   +2 more sources

Carotid Plaque‐Derived Small Extracellular Vesicles Mediate Atherosclerosis and Correlate With Plaque Vulnerability

MedComm, Volume 6, Issue 6, June 2025.
We profiled the differences in miRNA expression of plaque‐derived small extracellular vesicles (psEVs) from stable and vulnerable plaques of patients with asymptomatic carotid artery stenosis (aCAS), and identified five plasma‐derived sEV miRNAs as potential biomarkers for diagnosing plaque vulnerability.
Xin Xu, Taoyuan Lu, Yao Feng, Wenbo Cao, Dianwei Liu, Peng Gao, Yan Ma, Yabing Wang, Bin Yang, Yanfei Chen, Jian Chen, Ran Xu, Xinyu Wang, Lebin Chen, Yuanyuan Ji, Liqun Jiao   +15 more
wiley   +1 more source

VEGFR2 blockade reduces intraplaque haemorrhage and enhances plaque stability by augmentation of plaque neovessel maturation

, 2017
<p>Immature plaque neovessels contribute to atherosclerotic plaque instability and intraplaque haemorrhage by leaking erythrocytes and leukocytes in the plaque.
Paul Quax, Margreet de Vries (5366734), Erna Peters (5366740), Jaap Hamming (5366737), Marie-José Goumans (516094), Margreet de Vries, Erna Peters, Laura Parma, Marie-José Goumans, Laura Parma (5366743), Paul Quax (835172), Jaap Hamming   +11 more
core   +1 more source

Phenotypic Shifts in Macrophages Within Advanced Atherosclerotic Plaques in Humans

FASEB BioAdvances, Volume 7, Issue 6, June 2025.
The transition from a non‐atherosclerotic to an atherosclerotic artery is associated with a shift in macrophage phenotypes. In the homeostatic environment of a non‐atherosclerotic artery, macrophages are predominantly anti‐inflammatory, anti‐atherogenic.
Barbora Muffova, Sona Kauerova, Hana Bartuskova, Karel Paukner, Libor Janousek, Helena Cermakova, Jiri Fronek, Marek Kollar, Marek Petras, Jan Pitha, Rudolf Poledne, Ivana Kralova Lesna   +11 more
wiley   +1 more source

Diagnostics Accuracy of Magnetic Resonance Imaging in Detection of Atherosclerotic Plaque Characteristics in Carotid Arteries Compared to Histology: A Systematic Review

Journal of Magnetic Resonance Imaging, Volume 61, Issue 3, Page 1067-1093, March 2025.
Carotid plaque composition represents one of the main risk factors of future ischemic stroke. MRI provides excellent soft tissue contrast that can distinguish plaque characteristics. Our objective was to analyze the diagnostic accuracy of MRI imaging in the detection of carotid plaque characteristics compared to histology in patients with symptomatic ...
David Pakizer, Jiří Kozel, Jolanda Elmers, Janusz Feber, Patrik Michel, David Školoudík, Gaia Sirimarco   +6 more
wiley   +1 more source

A new murine model of stress-induced complex atherosclerotic lesions

Disease Models & Mechanisms, 2013
SUMMARY The primary purpose of this investigation was to determine whether ApoE−/− mice, when subjected to chronic stress, exhibit lesions characteristic of human vulnerable plaque and, if so, to determine the time course of such changes.
Amir H. Najafi, Nima Aghili, Justin U. Tilan, James A. Andrews, XinZhi Peng, Roberta M. Lassance-Soares, Subeena Sood, Lee O. Alderman, Ken Abe, Lijun Li, Frank D. Kolodgie, Renu Virmani, Zofia Zukowska, Stephen E. Epstein, Mary Susan Burnett   +14 more
doaj   +1 more source

Advances in moyamoya disease: pathogenesis, diagnosis, and therapeutic interventions

MedComm, Volume 6, Issue 2, February 2025.
The general morphology of moyamoya disease is described in the illustrated summary. The hyperplasia of the intima was found in the pathological tissue. In addition, the main research results of this review from genes, proteomics, metabolomics, immune involvement, and pathogenesis are summarized.
Shihao He, Zhenyu Zhou, Michelle Y. Cheng, Xiaokuan Hao, Terrance Chiang, Yanru Wang, Junze Zhang, Xilong Wang, Xun Ye, Rong Wang, Gary K. Steinberg, Yuanli Zhao   +11 more
wiley   +1 more source

Emerging understandings of the role of exosomes in atherosclerosis

Journal of Cellular Physiology, Volume 240, Issue 1, January 2025.
Abstract Atherosclerosis remains a major contributor to cardiovascular disease, the leading cause of global morbidity and mortality. Despite the elucidation of several molecular, biochemical, and cellular aspects that contribute to the etio‐pathogenesis of atherosclerosis, much remains to be understood about the onset and progression of this disease ...
Zena Wehbe, Maya Wehbe, Ali Al Khatib, Ali H. Dakroub, Gianfranco Pintus, Firas Kobeissy, Ali H. Eid   +6 more
wiley   +1 more source

Sonodynamic Therapy Suppresses Neovascularization in Atherosclerotic Plaques via Macrophage Apoptosis-Induced Endothelial Cell Apoptosis

JACC: Basic to Translational Science, 2020
Summary: During atherosclerosis plaque progression, pathological intraplaque angiogenesis leads to plaque rupture accompanied by thrombosis, which is probably the most important cause of arteries complications such as cerebral and myocardial infarction ...
Jianting Yao, MD, PhD, Weiwei Gao, MD, Yu Wang, MD, PhD, Lu Wang, PhD, Kamal Diabakte, MD, Jinyang Li, MD, Jiemei Yang, MD, Yongxing Jiang, MD, Yuerong Liu, MD, Shuyuan Guo, MD, Xuezhu Zhao, MD, Zhengyu Cao, MD, Xi Chen, MD, PhD, Qiannan Li, MD, Haiyu Zhang, PhD, Wei Wang, MD, Zhen Tian, PhD, Bicheng Li, MD, PhD, Fang Tian, MD, PhD, Guodong Wu, MD, Shirin Pourteymour, PhD, Xi Huang, MD, Fancheng Tan, MD, Xiaoru Cao, MD, Zhuowen Yang, MD, Kang Li, PhD, Yan Zhang, PhD, Yong Li, MD, PhD, Zhiguo Zhang, PhD, Hong Jin, MD, PhD, Ye Tian, MD, PhD   +30 more
doaj   +1 more source

Impact of Cardiovascular Risk Factors and Pharmacologic Treatments on Carotid Intraplaque Neovascularization Detected by Contrast-Enhanced Ultrasound

, 2019
Background: Neovascularization is a marker of plaque vulnerability that can be assessed noninvasively using contrast-enhanced ultrasound (CEUS). The presence and extent of plaque neovascularization and their relation to cardiovascular risk factors and ...
Norata, Giuseppe D., E. Ammirati, P. G. Camici, Ammirati, Enrico, F. Moroni, Camici, Paolo G., G. D. Norata, Magnoni, Marco, Moroni, Francesco, M. Magnoni   +9 more
core   +1 more source