Results 81 to 90 of about 24,723 (162)

CD40 Ligand+ Microparticles From Human Atherosclerotic Plaques Stimulate Endothelial Proliferation and Angiogenesis A Potential Mechanism for Intraplaque Neovascularization [PDF]

, 2008
ObjectivesOur goal was to demonstrate that microparticles (MPs) are the endogenous signal leading to neovessel formation through CD40 ligation in human atherosclerotic plaques.BackgroundVulnerable atherosclerotic plaques prone to rupture are ...
Tedgui, Alain, Boulanger, Chantal M., Lutgens, Esther, Leroyer, Aurélie S., Duriez, Micheline, Castier, Yves, Silvestre, Jean-Sébastien, Rautou, Pierre-Emmanuel, Lesèche, Guy, Devue, Cécile, Brandes, Ralf P.   +10 more
core   +1 more source

Molecular imaging of inflammation and intraplaque vasa vasorum: A step forward to identification of vulnerable plaques? [PDF]

, 2010
Current developments in cardiovascular biology and imaging enable the noninvasive molecular evaluation of atherosclerotic vascular disease. Intraplaque neovascularization sprouting from the adventitial vasa vasorum has been identified as an independent ...
Arend F. L. Schinkel, ten Cate, Folkert J., van der Steen, Antonius F. W., Sijbrands, Eric J. G., Eric J. G. Sijbrands, Mat J. A. P. Daemen, Roelf Valkema, Daemen, Mat J.A.P., Kate, G.L. (Luit) ten, Steven B. Feinstein, Steen, A.F.W. (Ton) van der, Cate, F.J. (Folkert) ten, Schinkel, Arend F. L., ten Kate, Gerrit L, Antonius F. W. van der Steen, Feinstein, S.B. (Steven), Daemen, M.J.A.P. (Mat), Valkema, Roelf, Valkema, R. (Roelf), Feinstein, Steven B, Folkert J. ten Cate, Sijbrands, E.J.G. (Eric), Schinkel, A.F.L. (Arend), Gerrit L. ten Kate, Sijbrands, E.J.G.; id_orcid, Feinstein, Steven B., Kate, GL, Sijbrands, E.J.G., van der Steen, Ton, Valkema, R., Daemen, MJAP, ten Cate, Folkert, ten Kate, Gerrit L., Schinkel, Arend, Daemen, Mat J. A. P., Feinstein, SB   +35 more
core   +4 more sources

Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision Targeting, Inflammatory Modulation, and Plaque Stabilization

Advanced Science, Volume 12, Issue 36, September 25, 2025.
This review first summarizes the complex pathogenesis of atherosclerosis and outlines the limitations of conventional therapies. It then explores innovative nanoparticle drug delivery system (NDDS) developments, detailing their precision targeting strategies, responsiveness to plaque‐specific stimuli, modulation of key pathological processes, and ...
Yunqi Zhang, Feifei Li, Libo Liu, Ziyu An, Hanzhong Luo, Huan Zhang, Rui Ma, Ruoxi Zhang, Qiong Dai, Mingduo Zhang, Jinfan Tian, Chaoyong Liu, Xiantao Song, Yunfeng Lu   +13 more
wiley   +1 more source

Effect of Neoatherosclerosis and Intervention‐Associated Neoatheroma Rupture on Clinical Outcomes in Patients With In‐Stent Restenosis: A Retrospective Study

Health Science Reports, Volume 8, Issue 7, July 2025.
ABSTRACT Background and Aims Treatment of drug‐eluting stents (DES) in‐stent restenosis (ISR) was challenging. Neoatherosclerosis (NA) occurs earlier and more frequently in DES‐ISR. This study aims to analyze the effect of neoatheroma morphology and intervention‐associated neoatheroma intima rupture on intervention strategies and clinical outcomes in ...
Xiao‐Xia Zhang, Qing Chen, Xiao‐Jiang Zhang, Yao‐Dong Ding, Guo‐Zhong Wang, Mao‐Xiao Nie, Yong Zeng   +6 more
wiley   +1 more source

A new murine model of stress-induced complex atherosclerotic lesions

Disease Models & Mechanisms, 2013
SUMMARY The primary purpose of this investigation was to determine whether ApoE−/− mice, when subjected to chronic stress, exhibit lesions characteristic of human vulnerable plaque and, if so, to determine the time course of such changes.
Amir H. Najafi, Nima Aghili, Justin U. Tilan, James A. Andrews, XinZhi Peng, Roberta M. Lassance-Soares, Subeena Sood, Lee O. Alderman, Ken Abe, Lijun Li, Frank D. Kolodgie, Renu Virmani, Zofia Zukowska, Stephen E. Epstein, Mary Susan Burnett   +14 more
doaj   +1 more source

Macrophage Signaling Pathways in Health and Disease: From Bench to Bedside Applications

MedComm, Volume 6, Issue 7, July 2025.
Macrophage functions in phagocytosis, tissue repair, immune regulation, and neuronal network protection. And graphic abract image in the attachment. ABSTRACT Macrophages exhibit remarkable functional plasticity by dynamically polarizing into proinflammatory or antiinflammatory subsets in response to microenvironmental cues. This duality underpins their
Yongquan Chi, Haipeng Jiang, Yiyuan Yin, Xinyu Zhou, Yiyouyou Shao, Yongsheng Li, Jianhua Rao   +6 more
wiley   +1 more source

α-Tocopherol inhibits atherogenesis and improves cardiac function in mice independently of its antioxidant properties

Vascular Biology
The impact of α-tocopherol on atherosclerosis is unclear and controversial. While some studies suggest potential benefits, such as antioxidant properties that may reduce oxidative stress, other studies indicate no significant preventive effects.
Isabelle Coornaert, Annelies Breynaert, Nina Hermans, Guido R Y De Meyer, Wim Martinet   +4 more
doaj   +1 more source

Current status and advances in ultrasound evaluation of neovascularization within carotid artery plaques: a systematic review

Cardiovascular Ultrasound
Vulnerable plaques are significant risk factors for acute ischemic events, and intraplaque neovascularization (IPN) is an important indicator for evaluating plaque vulnerability.
Yang Yang, Fangqin Liu, Jiaojun Yan, Yunhao Luo, Qiuyun Huang, Lang Qiao   +5 more
doaj   +1 more source

RED BLOOD CELL, HEMOGLOBIN AND HEME IN THE PROGRESSION OF ATHEROSCLEROSIS

Frontiers in Physiology, 2014
For decades plaque neovascularization was considered as an innocent feature of advanced atherosclerotic lesions, but nowadays growing evidence suggest that this process triggers plaque progression and vulnerability.
Viktória eJeney, Viktória eJeney, György eBalla, György eBalla, József eBalla   +4 more
doaj   +1 more source

The role of contrast-enhanced ultrasound in risk assessment of carotid atheroma [PDF]

Romanian Journal of Military Medicine, 2016
Background and objective: Contrast-enhanced ultrasound, used to assess atherosclerotic carotid plaques, improves visualization of vessel wall irregularities and depicts intraplaque neovascularization.
Silviu Stanciu, Cristina Enciu, Ioana Răduţă, Dan Stoicescu, Adrian Anghel, Daniela Anghel, B. Olan, Lucian Ciobîcă   +7 more
doaj