Results 71 to 80 of about 1,759 (164)

Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision Targeting, Inflammatory Modulation, and Plaque Stabilization

Advanced Science, Volume 12, Issue 36, September 25, 2025.
This review first summarizes the complex pathogenesis of atherosclerosis and outlines the limitations of conventional therapies. It then explores innovative nanoparticle drug delivery system (NDDS) developments, detailing their precision targeting strategies, responsiveness to plaque‐specific stimuli, modulation of key pathological processes, and ...
Yunqi Zhang, Feifei Li, Libo Liu, Ziyu An, Hanzhong Luo, Huan Zhang, Rui Ma, Ruoxi Zhang, Qiong Dai, Mingduo Zhang, Jinfan Tian, Chaoyong Liu, Xiantao Song, Yunfeng Lu   +13 more
wiley   +1 more source

Vasa vasorum and plaque neovascularization on contrast-enhanced carotid ultrasound imaging correlates with cardiovascular disease and past cardiovascular events

, 2010
BACKGROUND AND PURPOSE: Histological data associate proliferation of adventitial vasa vasorum and intraplaque neovascularization with vulnerable plaques represented by symptomatic vascular disease.
Feinstein, Steven B., Staub, Daniel, Johnson, Mahala, Espinosa, Paul, Ludden, David, Jaeger, Kurt A., Patel, Mita B., Tibrewala, Anjan, Coll, Blai   +8 more
core   +1 more source

Angiogenesis within atherosclerotic plaques: Mechanical regulation, molecular mechanism and clinical diagnosis

Mechanobiology in Medicine
Atherosclerosis (AS) is a disease characterized by focal cholesterol accumulation and insoluble inflammation in arterial intima, leading to the formation of an atherosclerotic plaque consisting of lipids, cells, and fibrous matrix. The presence of plaque
Hanxiao Chen, Chengxiu Peng, Fei Fang, Yuhao Li, Xiaran Liu, Ying Hu, Guixue Wang, Xiaoheng Liu, Yang Shen   +8 more
doaj   +1 more source

CD40 Ligand+ Microparticles From Human Atherosclerotic Plaques Stimulate Endothelial Proliferation and Angiogenesis A Potential Mechanism for Intraplaque Neovascularization

, 2008
ObjectivesOur goal was to demonstrate that microparticles (MPs) are the endogenous signal leading to neovessel formation through CD40 ligation in human atherosclerotic plaques.BackgroundVulnerable atherosclerotic plaques prone to rupture are ...
Tedgui, Alain, Boulanger, Chantal M., Lutgens, Esther, Leroyer, Aurélie S., Duriez, Micheline, Castier, Yves, Silvestre, Jean-Sébastien, Rautou, Pierre-Emmanuel, Lesèche, Guy, Devue, Cécile, Brandes, Ralf P.   +10 more
core   +1 more source

Effect of Neoatherosclerosis and Intervention‐Associated Neoatheroma Rupture on Clinical Outcomes in Patients With In‐Stent Restenosis: A Retrospective Study

Health Science Reports, Volume 8, Issue 7, July 2025.
ABSTRACT Background and Aims Treatment of drug‐eluting stents (DES) in‐stent restenosis (ISR) was challenging. Neoatherosclerosis (NA) occurs earlier and more frequently in DES‐ISR. This study aims to analyze the effect of neoatheroma morphology and intervention‐associated neoatheroma intima rupture on intervention strategies and clinical outcomes in ...
Xiao‐Xia Zhang, Qing Chen, Xiao‐Jiang Zhang, Yao‐Dong Ding, Guo‐Zhong Wang, Mao‐Xiao Nie, Yong Zeng   +6 more
wiley   +1 more source

Macrophage Signaling Pathways in Health and Disease: From Bench to Bedside Applications

MedComm, Volume 6, Issue 7, July 2025.
Macrophage functions in phagocytosis, tissue repair, immune regulation, and neuronal network protection. And graphic abract image in the attachment. ABSTRACT Macrophages exhibit remarkable functional plasticity by dynamically polarizing into proinflammatory or antiinflammatory subsets in response to microenvironmental cues. This duality underpins their
Yongquan Chi, Haipeng Jiang, Yiyuan Yin, Xinyu Zhou, Yiyouyou Shao, Yongsheng Li, Jianhua Rao   +6 more
wiley   +1 more source

Assessment of carotid atherosclerosis, intraplaque neovascularization, and plaque ulceration using quantitative contrast-enhanced ultrasound in asymptomatic patients with diabetes mellitus

, 2014
Aims Patients with diabetes mellitus (DM) are at severely increased risk of developing atherosclerosis. Intraplaque neovascularization (IPN) and plaque ulceration are markers of the vulnerable plaque, which is at an increased risk of rupture and may lead
Sijbrands, E.J.G.; id_orcid, Akkus, Z, van der Steen, Ton, Oord, Stijn, Renaud, G, Schinkel, Arend, Bosch, Hans, Sijbrands, E.J.G.   +7 more
core   +1 more source

Association between Pericytes in Intraplaque Neovessels and Magnetic Resonance Angiography Findings

, 2020
(1) Background: Pericytes are involved in intraplaque neovascularization of advanced and complicated atherosclerotic lesions. However, the role of pericytes in human carotid plaques is unclear. An unstable carotid plaque that shows high-intensity signals
Tatsuya Abe, Tomihiro Wakamiya, Shuji Sakata, Masashi Nishihara, Hiroyuki Irie, Jun Masuoka, Nobuaki Momozaki, Atsushi Ogata, Taichiro Mizokami, Tatsuya Tanaka   +9 more
core   +1 more source

Phase-specific turbulence index derived from vector flow imaging for identifying intraplaque neovascularization in carotid plaques

Frontiers in Cardiovascular Medicine
ObjectivesTo investigate the association between phase-specific turbulence index (Tur) derived from vector flow imaging (VFI) and intraplaque neovascularization (IPN) in carotid atherosclerotic plaques, and to evaluate its potential value as a ...
Qian Wang, Kefangyuan Zheng, Donghua Xian, Liuping Cui, Jiarui Bao, Yalan Fang   +5 more
doaj   +1 more source

Neovascularization and Intraplaque Hemorrhage in Atherosclerotic Plaque Destabilization-A Mathematical Model

Molecular & Cellular Biomechanics, 2019
Observational studies have identified angiogenesis from the adventitial vasa vasorum and intraplaque hemorrhage (IPH) as critical factors in atherosclerotic plaque progression and destabilization. Here we propose a mathematical model incorporating intraplaque neo vascularization and hemodynamic calculation for the quantitative evaluation of ...
Guo, Muyi, Cai, Yan, Li, Zhiyong
openaire   +2 more sources