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Intrathecal Baclofen Therapy: An Update
PM&R, 2009Intrathecal administration of baclofen is a well‐established technique for modulating hypertonia secondary to upper motor neuron pathology. Despite the nearly 2 decades of widespread clinical use, this intervention presents many challenges to even experienced clinicians.
Gerard E, Francisco +3 more
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Cyproheptadine for intrathecal baclofen withdrawal
Archives of Physical Medicine and Rehabilitation, 2003To evaluate the efficacy of cyproheptadine in the management of acute intrathecal baclofen (ITB) withdrawal.Descriptive case series.University hospital with a comprehensive in- and outpatient rehabilitation center.Four patients (3 with spinal cord injury, 1 with cerebral palsy) with implanted ITB infusion pumps for treatment of severe spasticity, who ...
Jay M, Meythaler +2 more
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American Journal of Physical Medicine & Rehabilitation, 1992
Electromyographic activity was recorded from tibialis anterior during nocturnal polysomnography in six patients with severe spasticity of spinal origin. The patients had a baclofen reservoir system implanted subcutaneously into their lumbar subarachnoid space and were studied for two nights in a double-blind, placebo controlled, crossover design ...
H M, Kravitz +5 more
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Electromyographic activity was recorded from tibialis anterior during nocturnal polysomnography in six patients with severe spasticity of spinal origin. The patients had a baclofen reservoir system implanted subcutaneously into their lumbar subarachnoid space and were studied for two nights in a double-blind, placebo controlled, crossover design ...
H M, Kravitz +5 more
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Intrathecal baclofen in the treatment of spasticity
2007Spasticity is a disorder of the sensorimotor system resulting in velocity-dependent increased muscle tone and tendon reflexes. Intrathecal baclofen is currently the most effective means of treating diffuse abnormal spasticity of both cerebral and spinal origin in the adult and pediatric patient.
D, Dykstra +4 more
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Intrathecal Baclofen Withdrawal
Pediatric Emergency Care, 2004Patients with severe spasticity are frequently encountered in the pediatric emergency department. Intrathecal baclofen therapy is being used increasingly to treat these patients. The purpose of this case series is to illustrate the importance of early recognition and treatment of intrathecal baclofen withdrawal, a potentially life-threatening ...
Noel S, Zuckerbraun +3 more
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Emergency Medicine, 1997
AbstractIntrathecal baclofen administered by bolus or continuous infusion has been shown to be of benefit in the treatment of spinal spasticity.Reporting of complications has been limited, particularly in the emergency medicine literature. Reports have been primarily associated with clinical trials.We report a case of intrathecal baclofen overdose in a
John Merchant, Gregory Hollis
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AbstractIntrathecal baclofen administered by bolus or continuous infusion has been shown to be of benefit in the treatment of spinal spasticity.Reporting of complications has been limited, particularly in the emergency medicine literature. Reports have been primarily associated with clinical trials.We report a case of intrathecal baclofen overdose in a
John Merchant, Gregory Hollis
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Intrathecal baclofen for the treatment of spasticity
2007Spasticity is a clinical condition characterized by a velocity-dependent increase of muscle tone due to "parapyramidal" disturbance of the inhibitory afferents to the second motor neuron. Intrathecal baclofen (ITB) is at present the most effective treatment tor generalized spasticity provided that an accurate assessment of patients to be candidates for
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Intrathecal baclofen for childhood hypertonia
Child's Nervous System, 2007Intrathecal baclofen was first introduced in 1985 to manage childhood hypertonia. There has been an evolution in thought as to how candidates should be identified and what forms of hypertonia respond to this treatment.This manuscript reviews the pharmacology of the drug, the assessment of candidates, the implantation of the infusion pump, and the usual
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Pharmacokinetics of Intrathecal Baclofen
1988Due to its polarity and water solubility, GABA (γ-aminobutyric acid), an inhibitory transmitter within the central nervous system, does not cross the blood-brain barrier and, therefore, is ineffective after oral or parenteral application [2]. Baclofen (β-(p-chlorphenyl)-γ-aminobutyric acid) was synthesised in 1965 as a GABA derivative with lipophilic ...
H. Müller +4 more
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