Results 91 to 100 of about 18,654 (227)
Pharmacogenetics of analgesic drugs [PDF]
, 2013 • Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R +4 more
core +1 more source
Health Science Reports, Volume 8, Issue 8, August 2025.ABSTRACT Background and Aims To compare the quality and duration of analgesia provided by Fentanyl and Sufentanil when added to 12–15 mg Bupivacaine 0.5% in spinal anesthesia for inguinal hernia surgery. Methods In the present double‐blind parallel Randomized Controlled Trial (RCT), 180 patients who were candidates for elective inguinal hernia surgery ...
Haniyeh Soleimany +3 more
wiley +1 more source
Tourniquetless Total Knee Arthroplasty With Modern Perioperative Protocols Decreases Pain and Opioid Consumption in Women [PDF]
, 2018 Background This study examined whether a modern total knee arthroplasty (TKA) protocol without a tourniquet results in less patient-reported pain and in-hospital opioid consumption compared to TKA with a tourniquet.
Dilley, Julian E. +4 more
core +1 more source
Intrathecal morphine remotely preconditions the heart via a neural pathway [PDF]
, 2012 Central opioid receptor activation triggers cardioprotection against ischemia reperfusion injury, independent of peripheral opioid receptor activity. Using a rodent model of myocardial ischemia reperfusion injury with infarct size as the primary outcome,
Irwin, MG, Wong, GTC, Xia, Z, Yao, L
core +1 more source
Cell Reports MedicineSummary: Long-term morphine use leads to tolerance and hyperalgesia in patients with chronic pain, with neuroinflammation playing a key role, but its underlying mechanisms remain elusive.
Bing Wang +11 more
doaj +1 more source
Alcohol Withdrawal – Therapeutical Management in Surgical Patients with Upper Intestinal Bleeding [PDF]
, 2015 Psychological dependence involves a desire to use a drug to avoid the unpleasant withdrawal syndrome that results from cessation of exposure to it. Alcohol withdrawal syndrome is one of the most feared complications of alcohol addiction and sometimes can
Bogdan, Popescu +5 more
core +4 more sources
Neuroleukemiosis Masquerading as Drug Toxicity in an Adolescent With Refractory AML
American Journal of Hematology, Volume 100, Issue 10, Page 1853-1858, October 2025.
Nia Choi +11 more
wiley +1 more source
Arquivos de Neuro-Psiquiatria, 2004 OBJECTIVE: To study the efficacy of intrathecal morphine infusion to treat spasticity. Setting: Functional Neurosurgery Division of University of São Paulo, Brazil. METHOD: Twelve patients with clinical refractory spasticity were studied. Two females and
Luis A. Rogano +2 more
doaj +1 more source
Mitogen-Activated Protein Kinase Signaling Mediates Morphine Induced-Delayed Hyperalgesia
Frontiers in Neuroscience, 2019 The use of morphine, the standard opioid drug, is limited by its undesirable effects, such as tolerance, physical dependence, and hyperalgesia (increased pain sensitivity).
Bárbara Guimaraes de Freitas +6 more
doaj +1 more source