Results 81 to 90 of about 10,244 (214)

Intrathecal Catheterization Influences Tolerance to Chronic Morphine in Rats [PDF]

, 2012
We evaluated the antinociceptive effects of acute and chronic morphine administered spinally via lumbar puncture in intrathecally catheterized and sham-surgery rats. The effects of acute morphine did not differ between groups. Catheterized rats developed
Milne, Brian, Jhamandas, Khem, Mattioli, Theresa-Alexandra, Sutak, Maaja, Cahill, Catherine M   +4 more
core   +1 more source

Targeting exosomal double-stranded RNA-TLR3 signaling pathway attenuates morphine tolerance and hyperalgesia

Cell Reports Medicine
Summary: Long-term morphine use leads to tolerance and hyperalgesia in patients with chronic pain, with neuroinflammation playing a key role, but its underlying mechanisms remain elusive.
Bing Wang, Dong-Sheng Le, Li Liu, Xue-Xue Zhang, Fan Yang, Guo-Rong Lai, Chao Zhang, Mai-Lin Zhao, Yun-Peng Shen, Ping-Sheng Liao, Tong Liu, Ying-Ping Liang   +11 more
doaj   +1 more source

Perioperative analgesia after intrathecal fentanyl and morphine or morphine alone for cesarean section

, 2017
Objectives: Intrathecal morphine is used in the postoperative management of pain after caesarean section (CS), but might not be optimal for intraoperative analgesia. We hypothesized that intrathecal fentanyl could supplement intraoperative analgesia when
Dabrowski, Michal J.,, Świetlana Krzemień-Wiczyńska, Kolacz, Marcin,, Monika Wielgus, Weigl, Wojciech,, Krzemien-Wiczynska, Swietlana,, Michał J. Dąbrowski, Andrzej Bieryło, Marcin Kołacz, Bierylo, Andrzej,, Wojciech Weigl, Wielgus, Monika,   +11 more
core   +1 more source

Successful treatment of intrathecal morphine overdose

, 2003
A 47-year-old woman was diagnosed with secondary progressive multiple sclerosis, and was treated with intrathecal morphine for chronic pain via a slow-release subcutaneous pump.
A. Sögüt, M. Kílínç, A. G. Sögüt, A. Yílmaz   +3 more
core   +1 more source

Intrathecal Morphine for Post-Thoracotomy Pain

Anesthesia & Analgesia, 1986
We wished to investigate possible differences in the duration of postoperative analgesia and the incidence of respiratory depression after the intrathecal injection in the lumbar area of 10 micrograms/kg morphine in hypobaric and hyperbaric solution for relief of post-thoracotomy pain.
J R, Gray, G A, Fromme, L A, Nauss, J K, Wang, D M, Ilstrup   +4 more
openaire   +3 more sources

A Prospective Randomized Dose-Finding Study of Intrathecal Opioids for Postoperative Analgesia After Minimally Invasive Colorectal Operation

Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Objective: To determine the optimal dose of intrathecal morphine and hydromorphone in patients undergoing minimally invasive colorectal operation for postoperative analgesia. Patients and Methods: The study was a double-blinded clinical dosing trial that
Patrice A. Vinsard, MD, Josef Pleticha, MD, Emily E. Sharpe, MD, Jason K. Panchamia, DO, David A. Olsen, MD, Hans P. Sviggum, MD, Sherief F. Shawki, MB, MD, Kevin T. Behm, MD, David W. Larson, MD, MBA, Allison M. LeMahieu, MS, Adam D. Niesen, MD, Adam W. Amundson, MD   +11 more
doaj   +1 more source

Is a Single Low Dose of Intrathecal Morphine a Useful Adjunct to Patient-Controlled Analgesia for Postoperative Pain Control Following Lumbar Spine Surgery? A Preliminary Report

Pain Research and Management, 2015
BACKGROUND: Several studies addressing intrathecal morphine (ITM) use following spine surgery have been published either involving the pediatric population, using mid- to high-dose ITM, or not in conjunction with morphine patient-controlled analgesia ...
David Yen, Kim Turner, David Mark
doaj   +1 more source

Long-term intrathecal morphine influence on major compounds of the endocrine system in elderly population

, 2009
Background The influence of long-term opioid administration on hormonal levels is not well characterized in the literature. We previously showed that intrathecal opioid therapy significantly influences the homeostasis of immune and endocrine systems ...
SAMOLSKY DEKEL, BOAZ GEDALIAHU, A. Caminiti, MELOTTI, RITA MARIA, D. Righetti, D. Sarti, M. Balestri, Marco Balestri, Boaz Gedaliahu Samolsky Dekel, Melotti Rita, Donatella Sarti, Fanelli Guido, W. Raffaeli, Donatella Righetti, G. Fanelli, Alessandro Caminiti, William Raffaeli   +15 more
core   +1 more source

Intrathecal morphine and blood pressure in preeclampsia.

, 1986
Ten term parturients with moderate-severe preeclampsia received intrathecal morphine for labor analgesia.
Gintautas, J, Humayun, S G, Doss, N W, Abadir, A R, Costas, C E, Kraynack, B J   +5 more
core  

Can repeated exposure to morphine change the spinal analgesic effects of lidocaine in rats?

Journal of Research in Medical Sciences, 2011
Background: Chronic opium exposure leads to altered response to opioid compounds. The aim of this study was to assess the behavioral effects of opium tolerance on the analgesic effects of intrathecal lidocaine in rats.
Ali Dabbagh, Shervin Farkhondehkish Moghadam, Samira Rajaei, Zahra Mansouri, Homa Shardi Manaheji   +4 more
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