Results 81 to 90 of about 18,654 (227)

Expert Strategies: Skull Base Reconstruction—Global Perspectives, Insights, and Algorithms through a Mixed Methods Approach

open access: yesInternational Forum of Allergy &Rhinology, Volume 15, Issue 10, Page 1032-1069, October 2025.
ABSTRACT Objective There is limited consensus on endoscopic skull base surgery (ESBS) reconstruction principles. This study aims to generate comprehensive themes regarding ESBS reconstruction by pooling the experiences of ESBS experts, with comparison to a literature review of current published evidence.
Edward C. Kuan   +77 more
wiley   +1 more source

An audit of intrathecal morphine analgesia for non-obstetric postsurgical patients in an adult tertiary hospital [PDF]

open access: yes, 2006
Publisher's copy made available with the permission of the publisher © Australian Society of AnaesthetistsWe conducted a retrospective audit of adult non-obstetric patients who had received a single dose of intrathecal morphine for postoperative ...
Lim, P., Macintyre, P.
core   +1 more source

A Rare Eisenmenger Syndrome Presentation in the Intensive Care

open access: yesClinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT This case report gives a lesson about the importance of being aware of subtle signs of cardiorespiratory distress in young patients. It reports an 18‐year‐old woman in whom a 19 mm ventricular septal defect was detected after a procedure, with acute cardiopulmonary deterioration being managed in the ICU.
Joana Alves Cabrita   +8 more
wiley   +1 more source

بررسی اثربخشی تزریق داخل نخاعی ترکیب سوفنتانیل و مورفین در کنترل درد بعد از عمل جراحی لاپاراتومی [PDF]

open access: yes, 2011
زمینه و هدف: هم اکنون روشهای مختلفی برای ایجاد بی دردی بعد از عمل وجود دارد مثل تزریق مخدرهای وریدی یا که هر یک دارای مزایا و PCA عضلانی، استفاده از داروهای ضد التهابی غیر استروئیدی (عضلانی ،وریدی یا رکتال ) و معایبی می باشند. یکی دیگر از روش های ایجاد
ایمان طلب, ولی   +6 more
core  

The pharmacotherapeutic potential of neuropeptide Y for chronic pain

open access: yesJournal of Internal Medicine, Volume 298, Issue 4, Page 280-296, October 2025.
Abstract Chronic pain is a major medical problem that requires new therapeutic options. Discovered by Victor Mutt in 1982, neuropeptide Y (NPY) is rapidly emerging as a master regulator of pain relief. Genetic knockdown of NPY or pharmacological inhibition of its receptors demonstrates that NPY signaling tonically inhibits indices of chronic ...
Al A. Nie, Bradley K. Taylor
wiley   +1 more source

Cetamina y analgesia preemptiva [PDF]

open access: yes, 2004
BACKAGROUND AND OBJECTIVES: Since the finding that ketamine blocks NMDA receptors in the neurons of spinal dorsal horn, it has been used to inhibit or decrease central sensitization triggered by nociceptive stimulations.
Garcia, João Batista Santos   +3 more
core   +5 more sources

Spinal Anaesthesia Versus General Anaesthesia for Patients With Tibia Shaft Fractures—A Randomized Controlled Study

open access: yesActa Anaesthesiologica Scandinavica, Volume 69, Issue 8, September 2025.
ABSTRACT Background Concerns about the delayed diagnosis of acute compartment syndrome have led to recommendations favouring general anaesthesia over spinal anaesthesia in surgeries for diaphyseal tibia fractures. However, there is a lack of supporting clinical evidence.
Pasi M. Lehto   +5 more
wiley   +1 more source

Nitrous Oxide: Mechanism of Its Antinociceptive Action [PDF]

open access: yes, 1995
Nitrous oxide (N2O) is an anesthetic gas known to produce an analgesic effect at sub-anesthetic concentrations. This analgesic property of N2O can be clinically exploited in a broad range of conditions where pain relief is indicated.
Quock, Raymond M., Vaughn, Linda K.
core   +1 more source

CXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain [PDF]

open access: yes, 2016
The roles of chemokine C-X-C motif ligand 12 (CXCL12) and its receptor chemokine C-X-C motif receptor 4 (CXCR4) reveal this chemokine axis as an emerging neuromodulator in the nervous system. In the peripheral and central nervous systems, both CXCL12 and
Cheung, CW   +4 more
core   +1 more source

Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule‐based mitochondrial transport disorder to morphine tolerance

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 17, Page 4058-4079, September 2025.
Abstract Background and Purpose Morphine is among the most powerful analgesic, but its long‐term use can cause tolerance. Synaptic ATP supply is critical for maintaining synaptic transmission. Microtubule‐based mitochondrial transport ensures synaptic energy supply.
Zheng Li   +9 more
wiley   +1 more source

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