Results 21 to 30 of about 9,756 (290)

Intratympanic corticosteroids for sudden sensorineural hearing loss

Cochrane Database of Systematic Reviews, 2022
Background Idiopathic sudden sensorineural hearing loss (ISSNHL) is common, and defined as a sudden decrease in sensorineural hearing sensitivity of unknown aetiology.
S. Plontke, C. Meisner, S. Agrawal, P. Cayé-Thomasen, Kevin Galbraith, A. Mikulec, L. Parnes, Y. Premakumar, Julia Reiber, A. Schilder, A. Liebau   +10 more
semanticscholar   +1 more source

Efficacy of Intratympanic OTO-104 for the Treatment of Ménière's Disease: The Outcome of Three Randomized, Double-Blind, Placebo-Controlled Studies

Otology and Neurotology, 2023
Objective To determine the efficacy of intratympanic OTO-104 for the treatment of Ménière's disease. Study Designs Three randomized, double-blind, placebo-controlled, multicenter studies of OTO-104 in patients with Ménière's disease.
J. Phillips, A. Mikulec, J. Robinson, D. Skarinsky, Jeffery J. Anderson   +4 more
semanticscholar   +1 more source

NOD2/RICK-dependent β-defensin 2 regulation is protective for nontypeable Haemophilus influenzae-induced middle ear infection. [PDF]

, 2014
Middle ear infection, otitis media (OM), is clinically important due to the high incidence in children and its impact on the development of language and motor coordination.
Lee, Yoo Jin, Lim, David J, Moon, Sung K, Oh, Sejo, Webster, Paul, Woo, Jeong-Im   +5 more
core   +10 more sources

Efficacy of intratympanic or postauricular subperiosteal corticosteroid injection combined with systemic corticosteroid in the treatment of sudden sensorineural hearing loss: A prospective randomized study

Frontiers in Neurology, 2023
Objectives This study aimed to investigate the efficacy and safety of intratympanic or postauricular subperiosteal glucocorticoid injection combined with systemic glucocorticoid in the treatment of sudden sensorineural hearing loss (SSNHL).
Wen Xie, Niki Karpeta, Jiali Liu, H. Peng, Chunhua Li, Zhi-ling Zhang, Yuehui Liu, M. Duan   +7 more
semanticscholar   +1 more source

Unilateral enlarged vestibular aqueduct syndrome and bilateral endolymphatic hydrops [PDF]

, 2017
Enlarged vestibular aqueduct (EVA) syndrome is a common congenital inner ear malformation characterized by a vestibular aqueduct with a diameter larger than 1.5 mm, mixed or sensorineural hearing loss that ranges from mild to profound, and vestibular ...
NOLA, GIUSEPPE, RALLI, Giovanni, RALLI, MASSIMO, Sparvoli, Luca   +3 more
core   +7 more sources

Primary versus salvage intratympanic steroid treatment for idiopathic sudden sensorineural hearing loss

Laryngoscope Investigative Otolaryngology, 2023
Objective The objective of this research is to compare primary and salvage intratympanic (IT) steroid treatments in terms of hearing outcomes in patients with idiopathic sudden sensorineural hearing loss (ISSNHL).
Wei‐Che Lan, Chia‐Der Lin, Yung‐An Tsou, Liang‐Chun Shih, Yu Aoh, Chien‐Chi Lu, Hsiu‐San Hsu, Chun‐Yu Lai, Ching‐Yuan Wang   +8 more
doaj   +1 more source

Intratympanic dexamethasone microcrystals/lidocaine-loaded PLGA non-spherical microparticles for local drug delivery to the inner ear. [PDF]

Animal Model Exp Med
Optimized lidocaine‐loaded PLGA non‐spherical particles (LPNMs) and dexamethasone microcrystals (DEX MCs) were prepared. They were then mixed in sodium hyaluronate solution to obtain a co‐delivery system, administrated in guinea pigs to evaluate the pharmacokinetics and biocompatibility of the system.
Wang D, Zhang X, Wang Z, Ran C, Hao J, Ma X, Wang M, Zhou Z.   +7 more
europepmc   +2 more sources

Consensus on intratympanic drug delivery for Menière’s disease

European Archives of Oto-Rhino-Laryngology, 2022
Intratympanic (IT) drug delivery receives attention due to its effectivity in treatment for Menière’s disease (MD). Due to the release of the consensuses and new evidence on IT drug delivery for MD have been published, the review with a view to ...
Shuna Li, I. Pyykkö, Qing Zhang, Jun Yang, M. Duan   +4 more
semanticscholar   +1 more source

Intratympanic Versus Systemic Steroid Therapy for Idiopathic Sudden Hearing Loss: A Systematic Review and Meta-Analysis

Cureus, 2022
Idiopathic sudden sensorineural hearing loss (ISSHL) is a common condition characterized by hearing threshold reduction, most often of unknown causes. The patient experiences a sudden reduction of the hearing threshold in one or both ears.
Christos Sialakis, C. Iliadis, A. Frantzana, P. Ouzounakis, L. Kourkouta   +4 more
semanticscholar   +1 more source

Improved Speech Intelligibility in Subjects With Stable Sensorineural Hearing Loss Following Intratympanic Dosing of FX-322 in a Phase 1b Study

Otology and Neurotology, 2021
Supplemental Digital Content is available in the text Objectives: There are no approved pharmacologic therapies for chronic sensorineural hearing loss (SNHL).
Will J McLean, Ashley S. Hinton, Jenna Herby, A. Salt, J. Hartsock, Sam Wilson, David L Lucchino, T. Lenarz, A. Warnecke, Nils Prenzler, H. Schmitt, Susan M. King, L. E. Jackson, J. Rosenbloom, G. Atiee, Moraye B. Bear, Christina L. Runge, R. Gifford, S. Rauch, Daniel J. Lee, R. Langer, J. Karp, C. Loose, Carl Lebel   +23 more
semanticscholar   +1 more source