Results 31 to 40 of about 4,501 (207)

Delivering Therapeutics to the Cochlea: The Importance of the Patient’s Perspective

Frontiers in Cellular Neuroscience, 2019
Hearing loss represents a major sensory impairment in humans with a strong impact on quality of life. The current standard of care for chronic sensorineural hearing loss is limited to hearing aids and implantable devices like cochlear implants ...
Marie-Josée Duran, Ralph Holme
doaj   +1 more source

Cochlear and vestibular effects of combined intratympanic gentamicin and dexamethasone

, 2017
OBJECTIVE: The aim of this study is to evaluate the effects of an intratympanic gentamicin-dexamethasone combination on the inner ear. MATERIALS and METHODS: Twenty-six Wistar albino rats were divided into four groups: Group I (Control), group II ...
Nuti D., Kirkim G., Yilmaz O., Mungan S., Olgun Y., Kolatan E., Ellidokuz H., Guneri E. A., Aktas S., Trabalzini F., Aslier M., Mandala M., Olgun, Yüksel, Trabalzini, Franco, Nuti, Daniele, Kırkım, Günay, Mandala, Marco, Mungan Durankaya, Serpil, Aktaş, Safiye, Güneri, Enis Alpin, Ellidokuz, Hülya, Aslıer, Mustafa, Kolatan, Hatice Efsun, Yılmaz, Osman   +23 more
core   +2 more sources

The Effects of Experimental Intratympanic Steroid Administration on Organ of Corti Type 1 Spiral Ganglion

International Archives of Otorhinolaryngology, 2018
Introduction It is unclear how effective is the intratympanic (IT) steroid treatment on organ of Corti type 1 spiral ganglion, its optimal dosage and frequency of administration.
Turgay Topcuoglu, Murat Kocyıgıt, Erdogan Bulut, Safiye G. Ortekın, Mehmet Kanter, Recep Yagız   +5 more
doaj   +1 more source

Intratympanic Steroid for Menière's Disease: A Systematic Review [PDF]

Otology & Neurotology, 2019
Objectives: To investigate the beneficial effects and safety of intratympanic steroid installation compared with placebo in patients with Menière's disease. Methods: We performed a systematic literature search in MEDLINE and EMBASE for existing systematic reviews and individual ...
Devantier, Louise, Djurhuus, Bjarki Ditlev, Hougaard, Dan Dupont, Händel, Mina Nicole, Guldfred, Frank Liviu-Adelin, Schmidt, Jesper Hvass, Edemann-Callesen, Henriette   +6 more
openaire   +3 more sources

Intratympanic mixture of gentamicin and dexamethasone versus dexamethasone alone and gentamycin alone in Meniere’s disease [PDF]

Al-Azhar International Medical Journal
Background: Meniere's disease (MD) is a complex clinical entity. It is characterized by auditory fullness, tinnitus, variable sensorineural hearing loss, and episodic vertigo.
Ibrahim Mohammed, Ali Mahrous, Mohamed Hamid, Ahmed Seddik Abdel Galil   +3 more
doaj   +1 more source

Comparison of 2 Different Intratympanic Methylprednisolone Injection Schedules in Combination With Intravenous Dexamethasone for Unilateral Sudden Sensorineural Hearing Loss

Ear, Nose & Throat Journal, 2021
Sudden sensorineural hearing loss is a common otologic disease in clinic. Systemic and intratympanic steroid treatment have been proved to be effective, but the regimens vary from center to center.
Yanlu Lyu MD, Fanqian Zeng MS, Min Yan MD, Zhou Zhou MS, Wei Zhang BS, Ming Liu MD, Chaoyang Ke MD   +6 more
doaj   +1 more source

A COMPARATIVE STUDY ON EFFICACY OF ORAL AND INTRATYMPANIC STEROIDS IN SUBJECTIVE IDIOPATHIC TINNITUS

, 2022
Background: Tinnitus is a common and annoying symptom caused by an abnormal spontaneous activity from within the auditory system. Corticosteroids is used as an empirical treatment in the oral form or as intratympanic injection for the treatment of this ...
Dhinakaran Natarajan , Vijay Babu and Rhea Anna Kurian
core   +1 more source

Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs

Frontiers in Pharmacology
Introduction: One major obstacle in validating drugs for the treatment or prevention of hearing loss is the limited data available on the distribution and concentration of drugs in the human inner ear.
Adele Moatti, Adele Moatti, Shannon Connard, Shannon Connard, Novietta De Britto, Novietta De Britto, William A. Dunn, Srishti Rastogi, Mani Rai, Mani Rai, Lauren V. Schnabel, Lauren V. Schnabel, Frances S. Ligler, Kendall A. Hutson, Douglas C. Fitzpatrick, Alec Salt, Carlton J. Zdanski, Alon Greenbaum, Alon Greenbaum   +18 more
doaj   +1 more source

New possibilities in the treatment of Meniere's disease [PDF]

Vojnosanitetski Pregled, 2002
The results of the treatment of Meniere's disease by intratympanic instillation of gentamicin in 32 patients over a 24-months period were analyzed. The receded vestibular function was found in 96,8% patients whereas in the remaining 3,2% pronounced ...
Milanović Nada, Kitanoski Boris, Ristić Boža, Jaćimović Violeta   +3 more
doaj   +1 more source

Effectiveness of intratympanic administration of gentamicin in unilateral menière’s disease

, 2020
To the Editor: In a recent issue published by Otology and Neurotology, Yaz et al. (1) presented an interesting work to analyze the effectiveness of an intratympanic (IT) injection of aminoglycosides compared to intratympanic corticosteroids to ...
Gioacchini F. M., Cavaliere M., Cassandro C., Scarpa A., Cassandro E., de Luca P., Ralli M.   +6 more
core   +1 more source