Results 41 to 50 of about 9,756 (290)

Intratympanic Therapies for Menière’s Disease [PDF]

Current Otorhinolaryngology Reports, 2014
There are multiple treatment options to consider when managing patients with Menière's disease. When conservative measures fail to control symptoms of Menière's disease, escalation of interventions may be required. Targeted drug delivery to the round window with intratympanic injections allows for local application of high concentrations of medications,
Matthew W, Miller, Yuri, Agrawal
openaire   +2 more sources

The Effects of Experimental Intratympanic Steroid Administration on Organ of Corti Type 1 Spiral Ganglion

International Archives of Otorhinolaryngology, 2018
Introduction It is unclear how effective is the intratympanic (IT) steroid treatment on organ of Corti type 1 spiral ganglion, its optimal dosage and frequency of administration.
Turgay Topcuoglu, Murat Kocyıgıt, Erdogan Bulut, Safiye G. Ortekın, Mehmet Kanter, Recep Yagız   +5 more
doaj   +1 more source

Intratympanic Steroid for Menière's Disease: A Systematic Review [PDF]

Otology & Neurotology, 2019
Objectives: To investigate the beneficial effects and safety of intratympanic steroid installation compared with placebo in patients with Menière's disease. Methods: We performed a systematic literature search in MEDLINE and EMBASE for existing systematic reviews and individual ...
Devantier, Louise, Djurhuus, Bjarki Ditlev, Hougaard, Dan Dupont, Händel, Mina Nicole, Guldfred, Frank Liviu-Adelin, Schmidt, Jesper Hvass, Edemann-Callesen, Henriette   +6 more
openaire   +4 more sources

Intratympanic Lipopolysaccharide Elevates Systemic Fluorescent Gentamicin Uptake in the Cochlea

The Laryngoscope, 2021
Lipopolysaccharide (LPS), a key component of bacterial endotoxins, activates macrophages and triggers the release of inflammatory cytokines in mammalian tissues.
Y. Chai, Weiwei He, Weiqiang Yang, Alisa P Hetrick, Jessica G Gonzalez, L. Sargsyan, Hao Wu, T. Jung, Hongzhe Li   +8 more
semanticscholar   +1 more source

Prediction of hearing recovery in sudden deafness treated with intratympanic steroids [PDF]

, 2018
The present study aims to obtain a probability model allowing the prediction of the auditory recovery in patients affected by sudden sensorineural hearing loss treated exclusively with intratympanic steroids.
Attanasio, G., Cagnoni, L., De Vincentiis, M., Di Porto, E., Greco, A., Masci, E., Ralli, M., RUSSO, FRANCESCA YOSHIE   +7 more
core   +1 more source

Impact of Systemic versus Intratympanic Dexamethasone Administration on the Perilymph Proteome.

Journal of Proteome Research, 2021
Glucocorticoids are the first-line treatment for sensorineural hearing loss, but little is known about the mechanism of their protective effect or the impact of route of administration.
Betsy Szeto, Chris Valentini, Aykut Aksit, Emily G. Werth, Shahar Goeta, L. Brown, E. Olson, J. Kysar, A. Lalwani   +8 more
semanticscholar   +1 more source

Adverse Effects of Steroid Therapy in Sudden Sensorineural Hearing Loss: A Scoping Review. [PDF]

Clin Otolaryngol
ABSTRACT Objective Sudden sensorineural hearing loss (SSNHL) is an otologic emergency and is treated with steroid therapy. Despite adverse events (AEs) associated with long‐term steroid use being well evidenced, there is sparsity of literature regarding the AEs of short‐course prescriptions in the SSNHL cohort, which limits the quality of patient ...
Achanta M, Kasetti P, Fortune-Ely M, Ross T, Magos T, Manjaly JG.   +5 more
europepmc   +2 more sources

Emerging pharmacotherapy of tinnitus [PDF]

, 2009
Tinnitus, the perception of sound in the absence of an auditory stimulus, is perceived by about 1 in 10 adults, and for at least 1 in 100, tinnitus severely affects their quality of life.
Ana Belén Elgoyhen, Azevedo AA, Bahmad FM, Berthold Langguth, Busto U, Courtney KR, Domeisen H, Feder R, Gananca MM, Goebel G, Goodnick PJ, Gresser U, Guitton MJ, Guitton MJ, Hastak SM, Henry JA, Hilton M, Holstein N, House JW, Kuchar DL, Langguth B, Lenarz T, Mahadevan S, Mardini MK, McCabe BF, Melcher JR, Moller AR, Moller AR, Newman CW, Oliver D, Podoshin L, Richard Salvi, Rogawski MA, Roth SH, Schlee W, Shambaugh GE, Shea JJ, Shulman A, Sieghart W, Tandon R, Wei BPC, Williams SH, Willow M, Zapp JJ   +43 more
core   +1 more source

Delivering Therapeutics to the Cochlea: The Importance of the Patient’s Perspective

Frontiers in Cellular Neuroscience, 2019
Hearing loss represents a major sensory impairment in humans with a strong impact on quality of life. The current standard of care for chronic sensorineural hearing loss is limited to hearing aids and implantable devices like cochlear implants ...
Marie-Josée Duran, Ralph Holme
doaj   +1 more source

Efficacy of Intratympanic Glucocorticoid Steroid Administration Therapy as an Initial Treatment for Idiopathic Sudden Sensorineural Hearing Loss During the COVID-19 Pandemic

Ear, nose, & throat journal, 2021
Objective: Systemic administration of glucocorticoid steroids is the most common initial treatment for idiopathic sudden sensorineural hearing loss (ISSNHL); however, due to the prevalence of coronavirus disease, the indications for this treatment must ...
T. Tsuda, Yukiko Hanada, Kento Wada, Erina Fujiwara, K. Takeda, H. Nishimura   +5 more
semanticscholar   +1 more source