Results 61 to 70 of about 9,756 (290)

A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss

Nature Communications
Inhibition of Notch signalling with a gamma-secretase inhibitor (GSI) induces mammalian hair cell regeneration and partial hearing restoration. In this proof-of-concept Phase I/IIa multiple-ascending dose open-label trial (ISRCTN59733689), adults with ...
Anne G. M. Schilder, Stephan Wolpert, Shakeel Saeed, Leonie M. Middelink, A. Edge, H. Blackshaw, Anne Leonie Albert Athanasios Elizabeth Asger Hannah Er Schilder Middelink Edge Bibas Arram Bilhet Cooper , Anne G. M. Schilder, Leonie M. Middelink, A. Edge, Athanasios G. Bibas, Elizabeth Arram, Asger Bilhet, Hannah Cooper, Ernst Dalhoff, Femke van Diggelen, Rolf Jan Rutten, Helmuth van Es, Karin Hojgaard, Eleftheria Iliadou, Omursen Yildirim, Sherif Khalil, Dimitris Kikidis, Hubert Lowenheim, Nikos Markatos, Marcus Mueller, Thore Schade-Mann, Fritz Schneider, Katerina Vardonikolaki, August Wilke, Kostas Pastiadis, Athanasios G. Bibas   +31 more
semanticscholar   +1 more source

The potential use of melatonin for preventing cisplatin ototoxicity : an insight for a clinical approach [PDF]

, 2014
Cisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies.
Araujo, Juliana Gusmão de, Oliveira, Carlos Augusto Costa Pires de, Sampaio, André Luiz Lopes, Venosa, Alessandra Ramos   +3 more
core   +3 more sources

Effect of Intratympanic Dexamethasone in Idiopathic Sudden Sensorineural Hearing Loss

Bengal Journal of Otolaryngology and Head Neck Surgery, 2019
Introduction Oral steroids currently represent the standard treatment for idiopathic sudden sensorineural hearing loss The aim of this study is to assess the effectiveness of intratympanic dexamethasone injection for treating ‘Idiopathic sudden ...
Rabi Hembrom, Indranil Sen, Bina Tamang, Satadal Mandal, Amit Chakrabarti   +4 more
doaj   +3 more sources

Intratympanic injection of dexamethasone for treatment of tinnitus in patients with sudden sensorineural hearing loss

Audiology Research, 2012
The purpose of this study is to test the effectiveness of intratympanic dexamethasone injections as a treatment for severe tinnitus in idiopathic sudden sensorineural hearing loss (SNHL).
Tadao Yoshida, Masaaki Teranishi, Tomoyuki Iwata, Hironao Otake, Tsutomu Nakashima   +4 more
doaj   +1 more source

Hyperbaric Oxygen Therapy for Sudden Sensorineural Hearing Loss after Failure from Oral and Intratympanic Corticosteroid [PDF]

Clinical and Experimental Otorhinolaryngology, 2012
Systemic and intratympanic steroids are most widely used for treating idiopathic sudden sensorineural hearing loss. Other treatments include vasodilator, immunosuppressant and antiviral medication. However, only 61% of patients achieve full recovery, and
Thanarath Imsuwansri, Pipat Poonsap, Kornkiat Snidvongs   +2 more
doaj   +1 more source

Prevention of cisplatin-induced hearing loss in children: Informing the design of future clinical trials. [PDF]

, 2018
Cisplatin is an essential chemotherapeutic agent in the treatment of many pediatric cancers. Unfortunately, cisplatin-induced hearing loss (CIHL) is a common, clinically significant side effect with life-long ramifications, particularly for young ...
Chang, Kay, Frazier, A, Freyer, David, Kelaghan, Joseph, Krailo, Mark, Minasian, Lori, OMara, Ann, Pollock, Bradley, Reaman, Gregory, Sung, Lillian   +9 more
core   +1 more source

Intratympanic Gels for Inner Ear Disorders: A Scoping Review of Clinical Trials.

Otolaryngology Head & Neck Surgery
OBJECTIVE Intratympanic injections are a safe, well tolerated procedure routinely performed by ENT's specialists. Intratympanic injections of gels have the potential to deliver therapeutics into the cochlea through the round window membrane prolonging ...
Davide Brotto, Marco Greggio
semanticscholar   +1 more source

Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs

Frontiers in Pharmacology
Introduction: One major obstacle in validating drugs for the treatment or prevention of hearing loss is the limited data available on the distribution and concentration of drugs in the human inner ear.
Adele Moatti, Adele Moatti, Shannon Connard, Shannon Connard, Novietta De Britto, Novietta De Britto, William A. Dunn, Srishti Rastogi, Mani Rai, Mani Rai, Lauren V. Schnabel, Lauren V. Schnabel, Frances S. Ligler, Kendall A. Hutson, Douglas C. Fitzpatrick, Alec Salt, Carlton J. Zdanski, Alon Greenbaum, Alon Greenbaum   +18 more
doaj   +1 more source

Inner Ear Therapeutics: An Overview of Middle Ear Delivery

Frontiers in Cellular Neuroscience, 2019
There are a variety of methods to access the inner ear and many of these methods depend on utilizing the middle ear as a portal. In this approach the middle ear can be used as a passive receptacle, as part of an active drug delivery system, or simply as ...
Jaimin Patel, Mikhaylo Szczupak, Suhrud Rajguru, Suhrud Rajguru, Carey Balaban, Michael E. Hoffer, Michael E. Hoffer   +6 more
doaj   +1 more source

Clinical Analysis of Intratympanic Injection of Dexamethasone for Treating Sudden Deafness

International Journal of General Medicine, 2021
Introduction A variety of causes may induce sudden deafness. However, it remains challenging to determine the exact cause in a clinic. There is no standard treatment for this disease due to its unclear etiology.
Xin Li, Wenjing Chen, Jia Xu, Haike Yi, Jingying Ye   +4 more
semanticscholar   +1 more source