INVESTIGATION OF AQUEOUS TWEEN 80 AS A VEHICLE FOR INTRAVAGINAL ADMINISTRATION
Journal of Endocrinology, 1971Abstract Tween 80 has been used for application of anti-inflammatory steroids to sensitive membranes (Johnson, 1959); it does not, however, appear to have been used for vaginal administration of oestrogens and antioestrogens which are often water insoluble.
E R, Clark, A M, McCracken
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Buccal versus intravaginal misoprostol administration for cervical ripening
American Journal of Obstetrics and Gynecology, 2002The purpose of this study was to compare the efficacy of misoprostol that is administered in the buccal pouch with the intravaginal route of administration.One hundred fifty-seven pregnant women with a singleton live gestation, Bishop score of
S J, Carlan +2 more
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Intravaginal Administration of Conjugated Estrogens in Premenopausal and Postmenopausal Women
International Journal of Gynecology & Obstetrics, 1980ABSTRACTDaily doses of 0.625 mg of conjugated estrogens were administered intravaginally for 14 days to 12 postmenopausal women (six with highly atrophic and six with slightly atrophic vaginal mucosa), resulting in vaginal mucosae similar to those found in premenopausal women in all 12 subjects.
M, Furuhjelm, E, Karlgren, K, Carlström
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Abortion of early pregnancy by the intravaginal administration of prostaglandin F2α
American Journal of Obstetrics and Gynecology, 1973Abstract Intravaginal prostaglandin F 2α (PGF 2α ) as an aqueous Tham salt solution was evaluated as a method for abortion of early gestations. Two drug concentrations were studied. All 4 patients treated with a 50 mg. per milliliter solution failed to abort and required dilatation and suction evacuation. Six of 8 gravidas treated with a 200 mg.
R J, Bolognese, S L, Corson
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Intravaginal oestrogen and progestin administration: advantages and disadvantages
Best Practice & Research Clinical Obstetrics & Gynaecology, 2008The vagina provides a local and a systemic route for delivering hormones for systemic effects and uterine targeting. Due to the 'uterine first-pass effect', hormones concentrate in the uterus and nearby tissues with low systemic exposure. Vaginal oestrogens, progesterone/progestins and danazol are currently used to obtain local (vagina and urethra ...
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Intravaginal administration of progesterone: enhanced absorption after estrogen treatment
Fertility and Sterility, 1981A progesterone solution was administered by intravaginal instillation, intramuscular injection, and sublingually to estrogen-deficient women, with or without estradiol (E2) replacement, and serum progesterone (P) concentrations were measured by radioimmunoassay. Intravaginal application to postmenopausal subjects receiving E2 gave the highest values of
B, Villanueva, R F, Casper, S S, Yen
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Plasma Progesterone Concentrations After Administration via Intravaginal Rings
Acta Obstetricia et Gynecologica Scandinavica, 1979Intravaginal rings (IVRs) fabricated from polysiloxane (silastic 382) and containing 708+ or -4.7 mg of progesterone (P) in the polysiloxane core of the ring were tested for efficacy of natural P administration through this route. 8 women volunteered.
T, Bäckström +2 more
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[Intravaginal administration of CDDP for adenocarcinoma].
Gan to kagaku ryoho. Cancer & chemotherapy, 1991Single vaginal administration of CDDP was done in a case of adenocarcinoma when relapse in the vaginal stump followed surgery for uterine corpus carcinoma. A tumor the size of a large fingertip in the vaginal stump was completely eliminated via 15-time (75 mg) CDDP vaginal administration, suggesting that this treatment was effective against ...
K, Nakayama, S, Nozawa, M, Yamaguchi
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Intravaginal Mesalamine Administration: A Novel Technique for Neovaginal Colitis
Journal of Pediatric and Adolescent GynecologyWe aim to present a novel technique for the treatment of neovaginal diversion colitis (also known as neovaginal colitis).OT is a 21-year-old cisgender female with a history of VACTERL who underwent a colonic vaginoplasty as an infant. She presented with symptoms indicative of and later diagnosed as neovaginal diversion colitis.
Andrew M, Lupo +4 more
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[Intravaginal administration of CDDP in cervical cancer].
Nihon Gan Chiryo Gakkai shi, 1990An 84-year-old woman was seen on June 19, 1989 with the chief complaint of excessive abnormal genital bleeding of 10 days' duration. The patient was diagnosed as FIGO stage IV b (positive metastasis to lung and Virchow's nodes) and was urgently admitted because of massive bleeding, which was well controlled by whole pelvic irradiation (Lineac 3,000 rad)
K, Nakayama +3 more
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