Results 21 to 30 of about 74,108 (188)

Paroxysmal Nocturnal Hemoglobinuria: Biology and Treatment

Medicina, 2023
Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant clonal hematopoietic disorder characterized by the lack of glycosylphosphatidylinositol-anchored proteins (GPI-APs) as a consequence of somatic mutations in the phosphatidylinositol glycan ...
Carlos Bravo-Perez, Luca Guarnera, Nakisha D. Williams, Valeria Visconte   +3 more
doaj   +1 more source

Acute Kidney Injury Following Naphthalene (Mothball) Poisoning

Saudi Journal of Kidney Diseases and Transplantation, 2023
Naphthalene is a widely available moth repellant in the Asian subcontinent. Toxicity can occur either accidentally or intentionally as a suicide attempt.
Piyush Mathur, Shalini Garg
doaj   +1 more source

Danicopan: an oral complement factor D inhibitor for paroxysmal nocturnal hemoglobinuria

Haematologica, 2020
Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated intravascular hemolysis due to the absence of complement regulators CD55 and CD59 on affected erythrocytes.
Antonio M. Risitano, Austin G. Kulasekararaj, Jong Wook Lee, Jaroslaw P. Maciejewski, Rosario Notaro, Robert Brodsky, Mingjun Huang, Michael Geffner, Peter Browett   +8 more
doaj   +1 more source

Acute tubular necrosis in a patient with paroxysmal nocturnal hemoglobinuria

Saudi Journal of Kidney Diseases and Transplantation, 2013
Acute renal failure (ARF) is a well-recognized complication of paroxysmal nocturnal hemoglobinuria (PNH). The predominant mechanism is intravascular hemolysis resulting in massive hemoglobinuria ARF.
Eranga S Wijewickrama, Lalindra Gooneratne, Chandu De Silva, Rushika L Lanarolle   +3 more
doaj   +1 more source

Rapid screening model for identifying patients with suspected intravascular hemolysis to improve patient care and reduce sample rejection rates in clinical chemistry

, 2021
The importance of developing a rapid screening model is critical for identifying patients with intravascular hemolysis to improve patient care and reduce sample rejection rates.
Davis, Gay Janet, Bwititi, Dr Phillip, Pioth, Gabriel Garang, Nwose, Dr Uba   +3 more
core   +1 more source

Hematological investigations in a case of intravascular hemolysis due to Clostridium perfringens infection. [PDF]

Biochem Med (Zagreb)
Graphical abstract Highlights • In vivo hemolysis due to C. perfringens infection occurred in an extremely short period • H index allowed monitoring severity of hemolysis and successful managing of samples • Laboratory procedure to investigate origin of ...
Beljan A, Blagec V, Bronic A, Pavić M.
europepmc   +2 more sources

Thrombotic Microangiopathy Associated with Gemcitabine in Non-Small Cell Lung Cancer: A Case Report

Case Reports in Oncology, 2021
A 69-year-old man with refractory lung adenocarcinoma was treated with gemcitabine and vinorelbine. Dyspnea and hypertension developed after the 17th cycle of chemotherapy.
Tadahiro Kuribayashi, Keiichi Fujiwara, Kiriko Onishi, Sho Mitsumune, Yuki Takigawa, Hiromi Watanabe, Kenichiro Kudo, Akiko Sato, Ken Sato, Masashi Kitagawa, Kosuke Ota, Yoko Shinno, Takuo Shibayama   +12 more
doaj   +1 more source

A Case of Childhood Severe Paroxysmal Cold Hemoglobinuria with Acute Renal Failure Successfully Treated with Plasma Exchange and Eculizumab

Case Reports in Pediatrics, 2022
We describe the case of a 4-year-old female who presented with sepsis and disseminated intravascular coagulation (DIC), developed ongoing intravascular hemolysis with acute renal failure from suspected pigment-induced acute tubular necrosis necessitating
Jessica Pelletier, Chad Ward, Matthew Borloz, Anne Ickes, Susan Guelich, Erwood Edwards   +5 more
doaj   +1 more source

How we (will) treat PNH?

Hematology, Transfusion and Cell Therapy, 2022
Clinical signs arising from intravascular hemolysis, hemolysis-related transfusions and thrombosis are indications for treatment initiation in paroxysmal nocturnal hemoglobinuria (PNH), whereas clone size per se is not.
Semra AYDIN
doaj   +1 more source

Vascular Diseases in PNH

Hematology, Transfusion and Cell Therapy, 2022
PNH is a condition in which uncontrolled complement activity leads to systemic complications, principally through intravascular hemolysis and platelet activation.
Hanan Hamed
doaj   +1 more source