Results 41 to 50 of about 74,108 (188)

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Image_1_Nrf2 Plays a Protective Role Against Intravascular Hemolysis-Mediated Acute Kidney Injury.tiff

, 2019
Massive intravascular hemolysis is associated with acute kidney injury (AKI). Nuclear factor erythroid-2-related factor 2 (Nrf2) plays a central role in the defense against oxidative stress by activating the expression of antioxidant proteins.
Ángel Sevillano (6910442), Melania Guerrero-Hue (6910436), Jesús Egido (108393), Cristina García-Caballero (6910439), Susana Cadenas (6910451), Carmen Herencia (172829), Eduardo Gutiérrez (746075), Belén de Andrés (843396), Juan Antonio Moreno (6910454), Javier Egea (1434796), Manuel Praga (746076), Pablo Cannata (6910445), Patrycja Michalska (3286632), María Luisa Gaspar (6910448), Claudia Yuste (746067), Cristina Vázquez-Carballo (6910433), Alberto Ortiz (108398), Rafael León (2512924), Alfonso Rubio-Navarro (503533), Isabel Cortegano (843393)   +19 more
core   +1 more source

Paroxysmal Nocturnal Hemoglobinuria (PNH): A Comprehensive Review

Haematology Journal of Bangladesh
Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, acquired clonal hemopoietic stem cell disorder characterized by complement mediated chronic intravascular haemolysis, bone marrow failure and life-threatening thrombosis.
Muhammad Kamruzzaman
doaj   +1 more source

Acute pancreatitis due to massive hemolysis in a child with glucose-6-phosphate dehydrogenase deficiency: A case Report

Journal of Pediatric Critical Care, 2023
The incidence of massive intravascular hemolysis causing pancreatitis is 25%; however, it is an often missed entity. Proinflammatory and immunoregulatory cytokines during hemolysis along with heme-induced neutrophil activation, chemoattraction, and ...
Bhavana Kayarat, Shreyas Gutte, Sourav Pal, Banani Poddar, Afzal Azim, Mohan Gurjar   +5 more
doaj   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Haemolysis after Amplatzer device closure of ventricular septal defect [PDF]

, 2007
Over the last few years, a vast variety of devices have been developed to close various septal defects through the transcatheter route. Haemolysis has been documented after Amplatzer device closure of patent ductus arteriousus, atrial septal defect ...
Mulvaney, Shirley, Grech, Victor E.
core  

Exploring hemolysis due to paravalvular leakage in artificial heart valves [PDF]

, 2020
Artificial heart valves require a surgical suture to keep them in place. These sutures can become infected or degrade over time, which can give rise to the phenomenon of paravalvular leakage.
Twitchell, Kyle
core  

Methemoglobinemia in Patient with G6PD Deficiency and SARS-CoV-2 Infection

Emerging Infectious Diseases, 2020
We report a case of intravascular hemolysis and methemoglobinemia, precipitated by severe acute respiratory syndrome coronavirus 2 infection, in a patient with undiagnosed glucose-6-phosphate dehydrogenase deficiency.
Kieran Palmer, Jonathan Dick, Winifred French, Lajos Floro, Martin Ford   +4 more
doaj   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Scrub Typhus Infection Precipitating Hemolysis in a Patient With G6PD Deficiency: A Case Report

Clinical Case Reports
Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is a well‐known red blood cell enzymopathy and a cause of intravascular hemolysis. This case report presents a child with underlying G6PD deficiency who experienced an acute episode of extensive ...
Ravi Shukla, Mandira Shrestha, Chaitanya Darshan Bhattarai, Kiran Lamichhane, Paras Yadav, Debendra Tamatta   +5 more
doaj   +1 more source