Results 121 to 130 of about 700,178 (349)

Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset [PDF]

, 2010
<p><b>Background and Purpose:</b> Antiplatelets (APs) may increase the risk of symptomatic intracerebral hemorrhage (ICH) following intravenous thrombolysis after ischemic stroke.</p> <p><b>Methods:</b> We ...
Ahmed, N., Diedler, J., Ford, G.A., Lees, K.R., Luijckx, G.J., Overgaard, K., Ringleb, P., Soinne, L., Sykora, M., Uyttenboogaart, M., Wahlgren, N.   +10 more
core   +2 more sources

Risk factors of haemorrhagic transformation for acute ischaemic stroke in Chinese patients receiving intravenous thrombolysis

Medicine, 2020
Aim: To determine the risk factors related to hemorrhagic transformation in Chinese patients with acute ischemic stroke treated with intravenous thrombolysis.
Lihong Wen, Song Zhang, K. Wan, Hong Zhang, Xiaoyun Zhang   +4 more
semanticscholar   +1 more source

Revisiting Incomplete Tissue‐Level Reperfusion Following Successful Thrombectomy for Acute Ischemic Stroke

Annals of Neurology, EarlyView.
Among patients with acute ischemic stroke achieving successful large vessel recanalization (defined as expanded Thrombolysis in Cerebral Infarction [eTICI ≥2b]), incomplete tissue‐level reperfusion, distinct from visually identifiable distal occlusion on digital‐subtraction angiography, remains a significant challenge.
Yue Qiao, Adrien Ter Schiphorst, Yi Xu, Jean‐Claude Baron, Wenbo Zhao   +4 more
wiley   +1 more source

Higher fibrinogen and neutrophil-to-lymphocyte ratio are associated with the early poor response to intravenous thrombolysis in acute ischemic stroke

Frontiers in Neurology
BackgroundInflammation and platelet activation play pivotal roles in acute ischemic stroke (AIS) pathogenesis. Early response to thrombolysis is a vital indicator for the long-term prognosis of AIS.
Mingzhu Deng, Kangping Song, Yangping Tong, Sufen Chen, Wei Xu, Guohua He, Jue Hu, Hui Xiao, Changmin Wan, Zhen Wang, Fangyi Li   +10 more
doaj   +1 more source

Stroke penumbra defined by an MRI-based oxygen challenge technique: 1. validation using [14C]2-deoxyglucose autoradiography [PDF]

, 2011
Accurate identification of ischemic penumbra will improve stroke patient selection for reperfusion therapies and clinical trials. Current magnetic resonance imaging (MRI) techniques have limitations and lack validation.
Barrie Condon, Celestine Santosh, Christopher McCabe, Craig A Robertson, I Mhairi Macrae, Keith W Muir, Kucinski T, Lindsay Gallagher, Maria del Rosario Lopez-Gonzalez, William M Holmes   +9 more
core   +1 more source

Neutrophil‐to‐lymphocyte ratio, hyperglycemia, and outcomes in ischemic stroke patients treated with intravenous thrombolysis

Brain and Behavior, 2020
Increased neutrophil‐to‐lymphocyte ratio (NLR) and hyperglycemia on admission are associated with poor outcomes in acute ischemic stroke (AIS) patients.
Yani Cheng, Anna Ying, Yanyan Lin, Junru Yu, Ji Luo, Y. Zeng, Yuanshao Lin   +6 more
semanticscholar   +1 more source

DNase1 RS1053874 Polymorphism is Associated with Early Neurological Recovery through NET Modulation and with Long‐Term Survival in Ischemic Stroke: A Prospective Cohort Study

Annals of Neurology, EarlyView.
Objective Immunothrombosis contributes to ischemic stroke pathophysiology through neutrophil extracellular trap (NET) formation, which promotes thrombus stabilization and microvascular dysfunction. DNase1 is the principal endonuclease responsible for NET degradation.
B. Díaz‐Benito, P. Calleja, L. Alzamora, A. Ruiz‐García, A. Martínez‐Salio, M. Muñoz‐García, F. Ostos, A. García‐Culebras, A. Moraga, M.A. Moro, I. Lizasoain   +10 more
wiley   +1 more source

Dose escalation of desmoteplase for acute ischemic stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset [PDF]

, 2006
<p><b>Background and Purpose:</b> Desmoteplase is a novel plasminogen activator with favorable features in vitro compared with available agents.
Al, R.Y., Albers, G.W., Eyding, D., Furlan, A.J., Hacke, W.l, Lees, K.R., Rowley, H.A., Sachara, C., Soehngen, M., Warach, S.   +9 more
core   +1 more source

Clinical Characteristics and Outcome of Patients With Hemorrhagic Transformation After Intravenous Thrombolysis in the WAKE-UP Trial

Frontiers in Neurology, 2020
Background: Hemorrhagic transformation (HT) is an important complication of intravenous thrombolysis with alteplase. HT can show a wide range from petechiae to parenchymal hematoma with mass effect with varying clinical impact.
Märit Jensen, E. Schlemm, B. Cheng, I. Lettow, F. Quandt, F. Boutitie, M. Ebinger, M. Endres, J. Fiebach, J. Fiehler, Ivana Galinovic, V. Thijs, R. Lemmens, K. Muir, N. Nighoghossian, S. Pedraza, C. Simonsen, C. Gerloff, G. Thomalla   +18 more
semanticscholar   +1 more source

Clot Composition Profiling in Large Vessel Occlusion Stroke Via Radiomics

Annals of Neurology, EarlyView.
Objective Clot composition may offer insights into the mechanism of ischemic stroke. Radiomics, a noninvasive imaging technique, enables tissue characterization through radiomic features (RFs). We aimed to evaluate clot composition using radiomics on non‐contrast computed tomography (NCCT).
Andres Gudino, Elena Sagues, Carlos Dier, Diego Ojeda, Samantha Saenz‐Hinojosa, Sebastian Sanchez, Ariel Vargas, Linder Wendt, Maria Belen Torres, Emily Garces, Alex Hanson, Navami Shenoy, Connor Aamot, Susan A. Walsh, Anil K. Chauhan, Gowri Anil‐Peethambar, Santiago Ortega‐Gutierrez, Jay Kinariwala, Mohamed Elshikh, Amir Shaban, Enrique C. Leira, Osorio Lopes Abath Neto, Malik Ghannam, Edgar A. Samaniego   +23 more
wiley   +1 more source