Results 101 to 110 of about 248,430 (244)

Impact of cerebral microbleeds on bleeding and outcome after stroke thrombolysis

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Background Cerebral microbleeds may be responsible for bleeding and poor functional outcome following thrombolysis of acute ischemic stroke. We tried to assess the association between cerebral microbleeds, hemorrhagic complication and functional outcome ...
Khaled Afifi, Ibrahim Al-Ahmer, Amira El-Hiebary, Shaimaa Hassanein, Mona Elkholy, Rasha Elkapany   +5 more
doaj   +1 more source

Intravenous thrombolysis for ischaemic strokes: a call for reappraisal [PDF]

Brain, 2014
Sir, Balami et al. (2013) state that intravenous tissue plasminogen activator thrombolysis is beneficial for the treatment of acute ischaemic stroke and that strokes are now a treatable medical emergency. A critical analysis of the data, however, raises doubts about the expansive claims of efficacy made by them and others (Wardlaw et al. , 2012).
openaire   +2 more sources

Biomimetic PB@PDA‐CA@Mem nanoplatform regulates oxidative stress and inflammatory microenvironment to enhance stroke recovery

VIEW, EarlyView.
PB@PDA‐CA@Mem enhances ischemic brain accumulation and enables acid‐responsive CA release. Through broad‐spectrum ROS/RNS scavenging, Nrf2/Keap1 activation, and NF‐κB/NLRP3 suppression, it alleviates oxidative stress and neuroinflammation, preserves neuronal architecture, reduces infarction, and improves functional recovery.
Lei Shi, Zhuonan Wang, Chenxi Zhou, Shuping Wang, Xuting Shen, Si Cheng, Yongli Yang, Nengrui Guo, Zhengrong Zhong, Lijun Bai   +9 more
wiley   +1 more source

CT-based intravenous thrombolysis 3-4.5 hours after acute ischemic stroke in clinical practice [PDF]

, 2011
BACKGROUND: Outcome of stroke patients selected with cerebral computed tomography for intravenous thrombolysis administered in clinical routine from 3 to 4.5 hours after symptoms onset is not well investigated.
Sarikaya, Hakan, Georgiadis, Dimitrios, Dimitrios Georgiadis, Braun, Julia; https://orcid.org/, Fischer, Andrea, Valko, Philipp O, Weck, A, Georgiadis, D, Braun, Julia, Hakan Sarikaya, Ralf W Baumgartner, Philipp O Valko, Andrea Fischer, Sarikaya, H, Baumgartner, R W, Weck, Anja, Julia Braun, Baumgartner, Ralf W, Fischer, A, Anja Weck, Valko, P O   +20 more
core   +1 more source

Intravenous thrombolysis in the context of stroke and cancer

Journal of Thrombosis and Thrombolysis
Abstract Background Cancer patients are at an increased risk for ischemic and hemorrhagic strokes. Ischemic stroke in this population often presents with distinctive features, such as cryptogenic etiology and multiple ischemic lesions, and is driven by cancer-associated coagulopathy ...
Alessandra Burini, Maurizio Paciaroni, Lucio D’Anna, Fedra Kuris, Valentina Maniaci, Mariarosaria Valente, Gian Luigi Gigli, Giovanni Merlino   +7 more
openaire   +3 more sources

Interventional oncology in children: Where are we now?

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel, Fernando Gómez Muñoz   +1 more
wiley   +1 more source

Early recurrent ischemic stroke in stroke patients undergoing intravenous thrombolysis

, 2006
BACKGROUND: We assessed the incidence of early recurrent ischemic stroke in stroke patients treated with intravenous tissue-type plasminogen activator (tPA) and the temporal pattern of its occurrence compared with symptomatic intracranial hemorrhage (ICH)
Baumann, Christian Rainer, Georgiadis, Dimitrios, Arnold, Marcel, Tettenborn, Barbara, Luethy, Regina, Giambarba, Christian, Engelter, Stefan, Lyrer, Philipp, Müller, Felix, Baumgartner, Ralf Werner, von Büdingen, Hans-Christian, Hungerbühler, Hansjörg   +11 more
core   +1 more source

Ethnic Differences in Outcomes of Endovascular Thrombectomy in New Zealand

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Introduction Stroke is a leading cause of morbidity and mortality in New Zealand, with ethnic disparities known to exist. Endovascular thrombectomy (EVT) has proven efficacy in reducing or preventing disability for stroke patients, but little is known about ethnic differences in functional outcomes following EVT in New Zealand.
Jaron Huang, Alicia Tyson, Muthu Muthappan, Annemarei Ranta   +3 more
wiley   +1 more source

Mean Platelet Volume-To-Lymphocyte Ratio Predicts Poor Functional Outcomes Among Ischemic Stroke Patients Treated With Intravenous Thrombolysis

Frontiers in Neurology, 2019
Background and Purpose: According to previous studies, the mean platelet volume-to-lymphocyte ratio (MPVLR) represents a novel marker of a poor short-term prognosis in patients with a myocardial infarction who underwent primary percutaneous coronary ...
Si-Yan Chen, Yuan-Shao Lin, Yi-Fan Cheng, Hong Wang, Xiao-Ting Niu, Wan-Li Zhang   +5 more
doaj   +1 more source

Highly potent, brain‐penetrant EP2 receptor antagonists for the treatment of permanent focal cerebral ischaemia in male and female mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Cerebral ischaemia is a leading cause of death in older adults and imposes a substantial global economic burden. Recent studies indicate that inhibiting the Gαs‐coupled EP2 receptor reduces ischaemic brain injury by modulating neuroinflammation.
Zhen Jin, Chenyao Jiang, Eun Bee Cho, M. Dennis Leo, Jiukuan Hao, Jiawang Liu, Ying Yu, Jianxiong Jiang   +7 more
wiley   +1 more source