Results 151 to 160 of about 373,665 (256)

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI.
Ladan Yeganeh, Nathalie Vermeulen, Carolyn Ee, Helena Teede, Amanda J. Vincent   +4 more
wiley   +1 more source

Ketogenic Diet Alleviates Colorectal Cancer by Attenuating Macrophage M2 Polarisation Triggered by Oncometabolite MMA Derived From the Gut Microbiota

Cell Proliferation, EarlyView.
Proposed mechanism of the ketogenic diet‐microbiota‐MMA‐immune axis in CRC. (Part 1) A ketogenic diet remodels gut microbiota homeostasis by depleting MMA‐producing bacteria, thereby reducing the accumulation of the oncometabolite (MMA). (Part 2) At the molecular level, MMA acts as a ligand that binds to Rap1, activating the downstream MAPK/ERK ...
Yang Lu, Bo Shi, Jinmiao Chen, Huihui Yao, Xiuwei Mi, Minke Shao, Yiyuan Zhao, Lijun Meng, Qingliang Tai, Junjie Chen, Xinyu Shi, Diyuan Zhou, Yizhou Yao, Songbing He   +13 more
wiley   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Intravenous vitamin C for bleeding control in elective C-sections: a randomized clinical trial study. [PDF]

Ann Med Surg (Lond)
Khakifirooz B, Mashak B, Hashemnejad M, Abdullahi S, Miri M, Amirpour-Kondelji F, Amirpour Z.   +6 more
europepmc   +1 more source

S1 Guideline: Therapy of generalized pustular psoriasis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary The S1 guideline “Therapy of generalized pustular psoriasis (GPP)” is a German guideline developed in accordance with the criteria of the AWMF. The full version addresses clinical presentation, pathogenesis, diagnosis and differential diagnosis, comorbidities, and therapy.
Rotraut Mößner, Neda Cramer, Sascha Gerdes, Ulrike Hüffmeier, Andreas Körber, Kai Krause, Christian Kromer, Katharina Antonia Langen, Sandra Philipp, Knut Schäkel, Michael P. Schön, Michael Schultheis, Lukas Sollfrank, Petra Staubach, Michael Sticherling, Johannes Wohlrab, Dagmar Wilsmann‐Theis, Cornelia Paul   +17 more
wiley   +1 more source

Vitamin C for COVID-19 Treatment: Have We Got Enough Evidence?

Frontiers in Nutrition, 2022
Siti Rohaiza Ahmad
doaj   +1 more source

Clinical benefits and risks of high-dose intravenous vitamin C: a systematic review. [PDF]

J Med Life
Alangari A, Arif J, Al Qureshah F, Alkhodairy F.   +3 more
europepmc   +1 more source

Surgical management of recurrent oesophageal obstruction in a yearling Saddlebred filly

Equine Veterinary Education, EarlyView.
Summary This case report describes the diagnostic approach and surgical management of a yearling Saddlebred filly with recurrent oesophageal obstruction, likely caused by an acquired extraluminal oesophageal stricture. The filly initially presented with repeated episodes of oesophageal obstruction, which were resolved with sedation and nasogastric ...
K. M. Andrews, J. Melcher, J. F. Peroni, M. Perlini, E. M. Beasley   +4 more
wiley   +1 more source