Results 11 to 20 of about 373,665 (256)

Impact of intravenous vitamin C as a monotherapy on mortality risk in critically ill patients: A meta-analysis of randomized controlled trials with trial sequential analysis. [PDF]

Front Nutr, 2023
Background This meta-analysis aimed at investigating the pooled evidence regarding the effects of intravenous vitamin C (IVVC) on mortality rate in critically ill patients.
Hung KC, Chuang MH, Chen JY, Hsu CW, Chiu CC, Chang YJ, Lee CW, Chen IW, Sun CK.   +8 more
europepmc   +2 more sources

Intravenous vitamin C monotherapy in critically ill patients: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis. [PDF]

Ann Intensive Care, 2023
Background A recent landmark randomized controlled trial (RCT) in septic patients demonstrated an increased risk of death and persistent organ dysfunction with intravenous Vitamin C (IVVC) monotherapy, which represents a disparate result from previous ...
Lee ZY, Ortiz-Reyes L, Lew CCH, Hasan MS, Ke L, Patel JJ, Stoppe C, Heyland DK.   +7 more
europepmc   +2 more sources

Effect of intravenous vitamin C on adult septic patients: a systematic review and meta-analysis. [PDF]

Front Nutr, 2023
Background An increasing number of studies indicate that vitamin C (VC) reduces the mortality of adult septic patients, while some articles suggest otherwise.
Liang H, Mu Q, Sun W, Liu L, Qiu S, Xu Z, Cui Y, Yan Y, Sun T.   +8 more
europepmc   +2 more sources

Biological Effects of Intravenous Vitamin C on Neutrophil Extracellular Traps and the Endothelial Glycocalyx in Patients with Sepsis-Induced ARDS. [PDF]

Nutrients, 2022
(1) Background: The disease-modifying mechanisms of high-dose intravenous vitamin C (HDIVC) in sepsis induced acute respiratory distress syndrome (ARDS) is unclear. (2) Methods: We performed a post hoc study of plasma biomarkers from subjects enrolled in
Qiao X, Kashiouris MG, L'Heureux M, Fisher BJ, Leichtle SW, Truwit JD, Nanchal R, Hite RD, Morris PE, Martin GS, Sevransky J, Fowler AA.   +11 more
europepmc   +2 more sources

A Pilot Feasibility Randomized Controlled Trial of Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit: The Lessening Organ Dysfunction with Vitamin C-India (LOVIT-India) Trial. [PDF]

Indian J Crit Care Med, 2023
Background The burden of sepsis is high in India and is associated with substantial morbidity and mortality. Vitamin C, an endogenous antioxidant, may improve patient outcomes.
Vijayaraghavan BKT, Venkataraman R, Ramanathan Y, Margabandhu S, Jayakumar D, Ramachandran P, Adhikari NK, Lamontagne F, Pinto R, Masse MH, Ménard J, Sprague S, Ramakrishnan N.   +12 more
europepmc   +2 more sources

Association of Oral or Intravenous Vitamin C Supplementation with Mortality: A Systematic Review and Meta-Analysis. [PDF]

Nutrients, 2023
Mortality is the most clinically serious outcome, and its prevention remains a constant struggle. This study was to assess whether intravenous or oral vitamin C (Vit-C) therapy is related to reduced mortality in adults. Data from Medline, Embase, and the
Xu C, Yi T, Tan S, Xu H, Hu Y, Ma J, Xu J.   +6 more
europepmc   +2 more sources

High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer. [PDF]

J Exp Clin Cancer Res, 2021
Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer agent when administered intravenously and in high doses (high-dose IVC).
Böttger F, Vallés-Martí A, Cahn L, Jimenez CR.   +3 more
europepmc   +2 more sources

Intravenous vitamin C use and risk of severity and mortality in COVID-19: A systematic review and meta-analysis. [PDF]

Nutr Clin Pract, 2022
The administration of intravenous vitamin C (IV‐VC) in treating patients with coronavirus disease 2019 (COVID‐19) is still highly controversial. There have been no previous studies on the effect of IV‐VC on the severity and mortality of COVID‐19.
Ao G, Li J, Yuan Y, Wang Y, Nasr B, Bao M, Gao M, Qi X.   +7 more
europepmc   +2 more sources

Oxidative Stress and Hyper-Inflammation as Major Drivers of Severe COVID-19 and Long COVID: Implications for the Benefit of High-Dose Intravenous Vitamin C. [PDF]

Front Pharmacol, 2022
Oxidative stress is a pivotal point in the pathophysiology of COVID-19 and presumably also in Long-COVID. Inflammation and oxidative stress are mutually reinforcing each other, thus contributing to the systemic hyperinflammatory state and coagulopathy ...
Vollbracht C, Kraft K.
europepmc   +2 more sources

High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial. [PDF]

Cancer Res Commun
High-dose intravenous vitamin C (HDIVC) administered to produce pharmacologic concentrations shows promise in preclinical models and small clinical trials, but larger prospective randomized trials are lacking.
Paller CJ, Zahurak ML, Mandl A, Metri NA, Lalji A, Heath E, Kelly WK, Hoimes C, Barata P, Taksey J, Garrison DA, Patra K, Milne GL, Anders NM, Nauroth JM, Durham JN, Marshall CH, Markowski MC, Eisenberger MA, Antonarakis ES, Carducci MA, Denmeade SR, Levine M.   +22 more
europepmc   +2 more sources