Pushing the limit: Globe salvage of Group D retinoblastoma with severe vitreous seeding with intra-arterial chemotherapy and 15 cycles of intravitreal chemotherapy [PDF]
American Journal of Ophthalmology Case ReportsPurpose: To report the successful treatment of persistent retinoblastoma vitreous seeding with 6 cycles of intra-arterial chemotherapy and 15 cycles of intravitreal chemotherapy injections.
Eugenia C. Greig +2 more
exaly +4 more sources
Complete preclinical platform for intravitreal chemotherapy drug discovery for retinoblastoma: Assessment of pharmacokinetics, toxicity and efficacy using a rabbit model [PDF]
MethodsX, 2021 Current melphalan-based intravitreal chemotherapy regimens for retinoblastoma vitreous seeds are effective, but cause significant ocular toxicity. We describe protocols for each step of a drug discovery pipeline for preclinical development of novel drugs
Anthony Daniels +2 more
exaly +4 more sources
Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma [PDF]
BMC Cancer, 2020 Background This study aimed to determine the efficacy and complications of intravitreal chemotherapy-assisted endoresection for refractory International Classification of Retinoblastoma (ICRB) group D retinoblastoma in monocular patients. Methods In this
Xiling Yu +5 more
doaj +2 more sources
The Antitumor Effect of Topotecan Loaded Thiolated Chitosan-Dextran Nanoparticles for Intravitreal Chemotherapy: A Xenograft Retinoblastoma Model [PDF]
Journal of Ophthalmic & Vision Research, 2023 Purpose: This research intended to fabricate the thiolated chitosan-dextran nanoparticles (NPs) containing topotecan (TPH-CMD-TCS-NPs) to assess the ability of NPs in improving the efficacy of intravitreal chemotherapy of retinoblastoma in a rabbit ...
Elham Delrish +9 more
doaj +2 more sources
Retinoblastoma in a 23-year-old adult treated with primary intra-arterial and intravitreal chemotherapy [PDF]
Oman Journal of Ophthalmology, 2019 Intra-arterial chemotherapy (IAC) continues to provide a globe-sparing alternative as primary treatment for retinoblastoma with few adverse events. While there is growing evidence to highlight the utility of IAC in children with retinoblastoma, adult ...
Jeffrey F McMahon +2 more
doaj +2 more sources
Central Retinal Vein Occlusion in the Absence of Conventional Risk Factors Associated With Breast Carcinoma: A Case Report. [PDF]
Clin Case RepUnusual association of central retinal vein occlusion and breast carcinoma. ABSTRACT Central retinal vein occlusion in 41‐year‐old female patients without conventional risk factors should raise concern for systemic evaluation for underlying malignancy and treatment‐related hypercoagulability.
Danyal Barry H +5 more
europepmc +2 more sources
Combined intra-arterial chemotherapy and intravitreal melphalan for the treatment of advanced unilateral retinoblastoma [PDF]
International Journal of Ophthalmology, 2020 "AIM: To evaluate the efficacy and safety of combined intra-arterial chemotherapy (IAC) and intravitreal melphalan (IVM) for the treatment of advanced unilateral retinoblastoma.
Ting-Yi Liang +4 more
exaly +2 more sources
The role of intravitreal chemotherapy for retinoblastoma
Indian Journal of Ophthalmology, 2015 Targeted therapy in retinoblastoma (RB) is widely accepted as the current management tool with an aim of increasing drug availability at the tumor location.
Fairooz P Manjandavida, Carol L Shields
doaj +2 more sources
High-dose topotecan (90 and 180 μG) for recurrent subretinal and vitreous seeding in retinoblastoma [PDF]
American Journal of Ophthalmology Case ReportsPurpose: To report on the use of intravitreal high-dose topotecan (90 and 180 μG) for recurrent subretinal and vitreous retinoblastoma, the toxicity of these injections, and the use of a 180-μG injection of intravitreal topotecan in humans. Observations:
David H. Abramson, Jasmine H. Francis
doaj +2 more sources
Role of additional topotecan injections (plus two) in reducing recurrence rate in retinoblastoma of group D and group E patients: a retrospective study [PDF]
BMJ Open OphthalmologyObjective To evaluate the effectiveness of administering additional intravitreal topotecan injections (plus two) in reducing the recurrence rate in patients with advanced retinoblastoma (RB).Methods and analysis This retrospective, non-comparative and ...
Qiang Liu +6 more
doaj +2 more sources