Results 51 to 60 of about 3,438 (125)

Intravitreal Melphalan Chemotherapy for Vitreous Seeds in Retinoblastoma

open access: yesJournal of Ophthalmology, 2020
Objective. To evaluate our experience with intravitreal melphalan chemotherapy as a second-line regimen for RB patients with refractory or recurrent vitreous seeds. Methods.
Yacoub A. Yousef   +9 more
doaj   +1 more source

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

open access: yesAdvanced Science, Volume 13, Issue 32, 9 June 2026.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren   +5 more
wiley   +1 more source

Photorefractive keratectomy in mild to moderate keratoconus: Outcomes in over 40-year-old patients

open access: yesIndian Journal of Ophthalmology, 2015
Background: Keratoconus is a contraindication for photorefractive keratectomy (PRK). In the recent decade, some efforts have been made to perform PRK in patients with keratoconus whose corneas are stable naturally or by doing corneal collagen ...
Hamid Khakshoor   +3 more
doaj   +1 more source

Economic evidence for licensed ready‐to‐administer intravenous products compared with standard vials and ampoules: a systematic review

open access: yesAnaesthesia, Volume 81, Issue 6, Page 867-874, June 2026.
Summary Introduction Injectable medicines represent a significant proportion of the annual medicines expenditure of the NHS in England, totalling £7 billion ($9.4 billion, €8.0 billion) in 2023. This represents approximately 70% of hospital medicines spending and includes essential treatments delivered at the point of care, such as chemotherapy ...
Suzanne Al‐Rawi   +2 more
wiley   +1 more source

Paradoxical Pyogenic Granuloma Associated With Ramucirumab but Not Bevacizumab: A Case Suggesting Differential Effects of VEGF Receptor and Ligand Inhibition

open access: yesRespirology Case Reports, Volume 14, Issue 5, May 2026.
We report a case of multifocal pyogenic granuloma that developed during ramucirumab therapy but did not recur after switching to bevacizumab. ABSTRACT Pyogenic granuloma is a benign vascular lesion that may bleed repeatedly and impair daily activities.
Akina Nigi   +3 more
wiley   +1 more source

Aptamer‐Functionalized Nanocarriers for Bone and Joint Diseases: Engineering Design Rules and Translational Roadmap

open access: yesSmall Science, Volume 6, Issue 5, May 2026.
Aptamer‐functionalized nanocarriers represent a versatile platform for targeted therapy in bone and joint diseases. This review presents five complementary design strategies: free aptamers for soluble targets, bispecific multivalent constructs for enhanced avidity, nanoparticle‐conjugated aptamers for selective tissue accumulation, aptamer‐based ...
Hamdi Al‐Azzani   +5 more
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos   +16 more
wiley   +1 more source

SELECTIVE INTRA-ARTERIAL CHEMOTHERAPY (IAC) IN TREATMENT AT CHILDREN WITH THE INTRAOCULAR RETYNOBLASTOMA

open access: yesСибирский онкологический журнал, 2018
Treatment of intraocular retinoblastoma is challenging. It requires a multidisciplinary personalized approach that includes focal treatments, chemotherapy, surgery and radiotherapy.
I. V. Pogrebnyakov
doaj   +1 more source

Choroidal metastases: Origin, features, and therapy

open access: yesIndian Journal of Ophthalmology, 2015
The choroid is the most common ocular site for metastatic disease, owing to abundant vascular supply. The primary cancers that most commonly lead to choroidal metastases include breast cancer (40-47%) and lung cancer (21-29%).
Sruthi Arepalli   +2 more
doaj   +1 more source

A case of subretinal tubercular abscess presenting as disc edema

open access: yesIndian Journal of Ophthalmology, 2015
We report a case of ocular tuberculosis (TB) which initially presented with disc edema and was mistaken for optic neuritis. With no definite pathology being identified, the patient was treated on the lines of optic neuritis with intravenous (IV) steroid ...
Sachin Bermu Shetty   +2 more
doaj   +1 more source

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