Subconjunctival delivery of p75NTR antagonists reduces the inflammatory, vascular, and neurodegenerative pathologies of diabetic retinopathy [PDF]
, 2017 The p75NTR is a novel therapeutic target validated in a streptozotocin mouse model of diabetic retinopathy. Intravitreal (IVT) injection of small molecule p75NTR antagonist THX-B was therapeutic and resolved the inflammatory, vascular, and ...
Barcelona, Pablo Federico +5 more
core +1 more source
Exogenous Endophthalmitis: Post-Operative versus Post-Intravitreal Injection
Vision Pan-America, 2012 Endophthalmitis is a potentially vision-threatening complication associated with nearly every intraocular or periocular procedure, including cataract surgery and intravitreal injection.
Jennifer L Rizzo +3 more
doaj +1 more source
Scientific Reports, 2021 Self-sealing hyaluronic acid (HA)-coated self-sealing 30-gauge needles exhibiting instant leakage prevention of intravitreal humor and injected drug were developed in this study. Ninety New Zealand rabbits were used in this study.
Youngsub Eom +10 more
doaj +1 more source
Comparison of Intravitreal Bevacizumab Upload Followed by a Dexamethasone Implant versus Dexamethasone Implant Monotherapy for Retinal Vein Occlusion with Macular Edema [PDF]
, 2012 Purpose: To compare the efficacy and safety of three intravitreal bevacizumab upload injections followed by a dexamethasone implant versus dexamethasone implant monotherapy in eyes with macular edema due to retinal vein occlusion.
Haritoglou, Christos +7 more
core +1 more source
Ultrastructural changes in the rabbit retina after various one-time doses of intravitreal melphalan
Journal of Ophthalmology, 2020 Background: Intravitreal chemotherapy (IVC) has become a common eye-preserving treatment for retinoblastoma (RB). However, there are still unsolved issues with regard to dosage of the cytostatic agent, its ultrastructural effects on healthy retinal cells,
N.F. Bobrova +3 more
doaj +1 more source
Corticosteroid implants for chronic non-infectious uveitis. [PDF]
, 2016 BACKGROUND: Uveitis is a term used to describe a heterogeneous group of intraocular inflammatory diseases of the anterior, intermediate, and posterior uveal tract (iris, ciliary body, choroid).
Brady, Christopher J +7 more
core +2 more sources
Treatment chronic macular edema in Vogt-Koyanagi Harada syndrome with dexamethasone intravitreal implant: description of three case [PDF]
, 2015 Purpose: To report our experience with dexamethasone intravitreal implant (Ozurdex, DEX implant) in the chronic cystic macular edema (ME )with Vogt-Koyanagi-Harada (VKH) Syndrome. Method: A retrospective chart review of three patients with (VKH) treated
Albanese, Giorgio +5 more
core +1 more source
Therapeutic approaches with intravitreal injections in geographic atrophy secondary to age-related macular degeneration: current drugs and potential molecules [PDF]
, 2019 The present review focuses on recent clinical trials that analyze the efficacy of intravitreal therapeutic agents for the treatment of dry age-related macular degeneration (AMD), such as neuroprotective drugs, and complement inhibitors, also called ...
Cerini, Alberto +5 more
core +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
Effectiveness of aflibercept in treating bevacizumab resistant macular edema [PDF]
Basrah Journal of SurgeryAim Method Prospective study on patients with macular edema secondary to diabetes mellitus, retinal vein occlusion or wet AMD. All the patients enrolled in the study had partial or no response to bevacizumab represented by mild or no improvement
Hussain Khudair Yassin
doaj +1 more source