Results 201 to 210 of about 111,693 (253)

Investigation of the utility of published in vitro intrinsic clearance data for prediction of in vivo clearance

Journal of Pharmacological and Toxicological Methods, 2006
This study was conducted to compare and contrast published in vitro intrinsic clearance values reported for compounds from different laboratories and the predictivity of these data to project in vivo clearance.A total of 103 compounds were selected for investigation and an exhaustive literature search was conducted to identify in vitro intrinsic ...
Keith W Ward
exaly   +3 more sources

Comparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes

Xenobiotica, 2009
1. We compared the intrinsic clearance (CL(int)) of a number of substrates in suspensions of fresh and cryopreserved human hepatocytes from seven donors. 2. CL(int) values for a cocktail incubation of phenacetin, diclofenac, diazepam, bufuralol, midazolam, and hydroxycoumarin were 4.9 +/- 3.4, 18 +/- 7.2, 5.1 +/- 4.9, 6.3 +/- 3.3, 9.8 +/- 5.8 and 22 +/-
E, Floby, J, Johansson, J, Hoogstraate, N J, Hewitt, J, Hill, A-K, Sohlenius-Sternbeck   +5 more
exaly   +3 more sources

Prediction of hepatic microsomal intrinsic clearance and human clearance values for drugs

Journal of Molecular Graphics and Modelling, 2009
Twenty-nine drugs of different structures were used in theoretical QSAR analysis of human hepatic microsomal intrinsic clearance (in vitro T(1/2) and in vitro CL'(int)) and whole body clearance (CL(blood)). The examined compounds demonstrated a wide range of scaled intrinsic clearance values. Constitutional, geometrical, physico-chemical and electronic
Katarina Nikolic
exaly   +5 more sources

A METHOD OF DETERMINING INTRINSIC HEPATIC CLEARANCE FROM THE FIRST-PASS EFFECT

Clinical and Experimental Pharmacology and Physiology, 1980
SUMMARY1. The relation between systemic hepatic clearance, intrinsic hepatic clearance and hepatic blood flow is considered from the point of view of the sinusoidal perfusion (parallel tube) model of the liver.2. It is shown how intrinsic hepatic clearance may be calculated, for substrates eliminated in the liver and the kidney only, from data obtained
Bass L., Winkler K.
exaly   +5 more sources

Frequency Distribution of Bilirubin Intrinsic Clearance in Adult Male Sprague–Dawley Rats

Journal of Pharmaceutical Sciences, 1978
The intrinsic body clearance of bilirubin was determined in 48 adult male Sprague--Dawley rats that received an intravenous infusion of bilirubin. The intrinsic body clearance was calculated from the infusion rate, the steady-state plasma concentration of total (free and protein-bound) bilirubin, and the free fraction of bilirubin in plasma.
S Öie
exaly   +3 more sources

Use of intrinsic clearance for prediction of human hepatic clearance

Expert Opinion on Drug Metabolism & Toxicology, 2010
The use of intrinsic metabolic stability/clearance and other in vitro pharmacokinetic data for the selection of drug candidates for clinical evaluation during discovery lead optimization has become one of the primary focuses of research organizations involved in new drug discovery.
Piyun, Chao, Annette S, Uss, K C, Cheng
openaire   +2 more sources

In Vivo Biliary Clearance Should Be Predicted by Intrinsic Biliary Clearance in Sandwich-Cultured Hepatocytes

Drug Metabolism and Disposition, 2012
It has been reported that in vivo biliary clearance can be predicted using sandwich-cultured rat and human hepatocytes. The predicted apparent biliary clearance (CL(bile, app)) from sandwich- cultured rat hepatocytes (SCRH) based on medium concentrations correlates to in vivo CL(bile, app) based on plasma concentrations of angiotensin II receptor ...
Masanori, Nakakariya, Midori, Ono, Nobuyuki, Amano, Toshiya, Moriwaki, Kazuya, Maeda, Yuichi, Sugiyama   +5 more
openaire   +2 more sources